NOTCH3 and TNNT2

Number of citations of the paper that reports this interaction (PubMedID 25356737)
22

Data Source:
BioGRID (pull down)

		NOTCH3	TNNT2
Description		notch receptor 3	troponin T2, cardiac type
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Membrane Receptor Complex	Cytosol Troponin Complex Striated Muscle Thin Filament Sarcomere Cardiac Myofibril Cardiac Troponin Complex
	Molecular Function	Calcium Ion Binding Protein Binding Enzyme Binding Signaling Receptor Activity Identical Protein Binding Cadherin Binding	Microfilament Motor Activity Actin Binding Protein Binding Tropomyosin Binding Troponin C Binding Troponin I Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Notch Signaling Pathway Axon Guidance Neuroblast Differentiation Cell Differentiation Neuron Differentiation Forebrain Development Negative Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Artery Morphogenesis Regulation Of Developmental Process Glomerular Capillary Formation Positive Regulation Of MiRNA Transcription	Regulation Of Muscle Contraction Striated Muscle Contraction Regulation Of Heart Contraction Muscle Filament Sliding Negative Regulation Of ATP-dependent Activity Positive Regulation Of ATP-dependent Activity Sarcomere Organization Response To Calcium Ion Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Noncanonical activation of NOTCH3	Striated Muscle Contraction
Drugs
Diseases		Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)	Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM)
GWAS		Pulse pressure ( 27841878 30578418) Toxoplasma gondii sag1 antibody levels ( 33204752)	Cardiac Troponin-T levels ( 23247143) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 28552196) Neurofibrillary tangles ( 25188341)
Interacting Genes		54 interacting genes: ANKRD28 BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 HOXA1 JAG1 JAG2 KAT2B LINC00839 LTBP1 MAML1 MAML2 MAML3 MBD1 MPPED2 MTDH MYC NEDD9 NUFIP2 PPIA PRR20A PRR20B PRR20C PRR20D PRR20E PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SHANK3 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 UPF1 WDR25 XKR8	16 interacting genes: APP KDM1A MAP3K5 MLX MORF4L1 MORF4L2 MST1 NOTCH3 PPP2R5A PRKCA TNNC1 TNNI1 TNNI3 TNNT1 TPM1 TRIM69
Entrez ID		4854	7139
HPRD ID		02607	01844
Ensembl ID		ENSG00000074181	ENSG00000118194
Uniprot IDs		Q9UM47	A0AAQ5BHX3 P45379 Q15607
PDB IDs		4ZLP 5CZV 5CZX 6WQU 6XSW 8OS0	1J1D 1J1E 4Y99 6KN7 6KN8 7UTI 7UTL 8FMM 8FMN 8FMO 8FMP 8FMQ 8FMR 8FMS 8FMT
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Notch Binding Tissue Morphogenesis Regulation Of Timing Of Cell Differentiation Regulation Of Notch Signaling Pathway Regulation Of Development, Heterochronic MAML1-RBP-Jkappa- ICN1 Complex Blood Vessel Endothelial Cell Fate Specification Auditory Receptor Cell Fate Commitment Tube Morphogenesis Positive Regulation Of Developmental Process Endothelial Cell Fate Specification Morphogenesis Of An Epithelium Cell Surface Receptor Signaling Pathway Loop Of Henle Development Calcium Ion Binding Neuron Differentiation Myoblast Differentiation Negative Regulation Of Viral Life Cycle Aspartic Endopeptidase Activity, Intramembrane Cleaving Membrane Protein Proteolysis Inhibition Of Neuroepithelial Cell Differentiation Gamma-secretase Complex Positive Regulation Of Signal Transduction Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Signaling Positive Regulation Of RNA Metabolic Process Negative Regulation Of Stress-activated MAPK Cascade Lymphocyte Migration Into Lymphoid Organs Notch Receptor Processing Transcription Coactivator Activity Negative Regulation Of Notch Signaling Pathway Epithelial Tube Morphogenesis Positive Regulation Of Kidney Development Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Amyloid-beta Formation Somitogenesis Anatomical Structure Morphogenesis Cognition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Signal Transduction Stem Cell Population Maintenance Endothelial Tube Morphogenesis Segmentation Maintenance Of Cell Number Positive Regulation Of Cellular Component Organization Nephron Development Inner Ear Development	Troponin Complex Troponin T Binding Striated Muscle Contraction Skeletal Muscle Contraction Transition Between Fast And Slow Fiber Regulation Of Muscle System Process Cardiac Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Skeletal Muscle Adaptation Cardiac Muscle Tissue Morphogenesis Regulation Of System Process Muscle Filament Sliding Regulation Of Muscle Contraction Actin-myosin Filament Sliding Muscle Tissue Morphogenesis Muscle Contraction Cardiac Troponin Complex Muscle System Process Actin-mediated Cell Contraction Regulation Of Smooth Muscle Cell Proliferation Sarcomere Actin Filament-based Movement Regulation Of Double-strand Break Repair Via Homologous Recombination Contractile Muscle Fiber Positive Regulation Of Smooth Muscle Cell Proliferation Anatomical Structure Morphogenesis System Process Regulation Of DNA Recombination NuA4 Histone Acetyltransferase Complex Regulation Of Double-strand Break Repair Protein Homodimerization Activity Neuron Maturation Positive Regulation Of RNA Biosynthetic Process Enzyme Binding Cytosol Positive Regulation Of DNA-templated Transcription Response To Reactive Oxygen Species Tissue Morphogenesis Actin Filament-based Process Sarcomere Organization Amyloid-beta Complex Growth Cone Lamellipodium Chromatin Organization Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Muscle Filament Sliding Speed Actin Filament Binding
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