ATP1B3 and UPF2

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		ATP1B3	UPF2
Description		ATPase Na+/K+ transporting subunit beta 3	UPF2 regulator of nonsense mediated mRNA decay
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Sodium:potassium-exchanging ATPase Complex Membrane Basolateral Plasma Membrane Apical Plasma Membrane Sperm Flagellum Melanosome Extracellular Exosome	Nucleus Cytoplasm Cytosol Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm
	Molecular Function	ATPase Activator Activity Protein Binding Protein-macromolecule Adaptor Activity ATPase Binding Transporter Activator Activity	RNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Intracellular Potassium Ion Homeostasis Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Protein Stabilization Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Membrane Repolarization Positive Regulation Of Sodium Ion Export Across Plasma Membrane Positive Regulation Of Potassium Ion Import Across Plasma Membrane Potassium Ion Import Across Plasma Membrane	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration
Pathways		Basigin interactions Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Bisacodyl Tegoprazan
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Pulse pressure ( 27841878) Red cell distribution width ( 27863252 28957414 32888494) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 26503584) Total hippocampal volume ( 30279459) Waist-hip ratio ( 28552196) White blood cell count ( 32888494)	Diverticular disease ( 30177863)
Interacting Genes		15 interacting genes: BAALC BARD1 BRCA1 CTXN3 MYCBP2 NLRP3 OGT PAXIP1 PEA15 SMAGP STOM TMEM98 TRIM14 UPF2 USP4	78 interacting genes: ABCF2 AGPAT1 AKTIP ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 GATA3 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SSBP2 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44
Entrez ID		483	26019
HPRD ID		03521	10405
Ensembl ID		ENSG00000069849	ENSG00000151461
Uniprot IDs		P54709	Q9HAU5
PDB IDs			1UW4 2WJV 4CEK 4CEM 7NWU 7QG6
Enriched GO Terms of Interacting Partners?		Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification DNA Strand Resection Involved In Replication Fork Processing RNA Polymerase Binding Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Damage Checkpoint Protein K6-linked Ubiquitination Ubiquitin Protein Ligase Activity Response To Ionizing Radiation Negative Regulation Of Gene Expression Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Homologous Recombination Post-translational Protein Modification Negative Regulation Of Macromolecule Metabolic Process Pyroptotic Inflammatory Response Regulation Of Protein Localization Negative Regulation Of MRNA 3'-end Processing Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Adenosine Receptor Binding Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Mitotic G2/M Transition Checkpoint Negative Regulation Of Metabolic Process DNA Recombination Regulation Of Protein Metabolic Process TORC1 Signaling Negative Regulation Of Protein Metabolic Process Positive Regulation Of TORC1 Signaling Circadian Regulation Of Gene Expression Protein Modification Process Protein Polyubiquitination Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Ionizing Radiation Regulation Of Protein Modification Process Negative Regulation Of Protein Ubiquitination Regulation Of Macromolecule Biosynthetic Process	RNA Binding Nuclear-transcribed MRNA Catabolic Process RNA Catabolic Process MRNA Catabolic Process Nucleobase-containing Compound Catabolic Process RRNA Metabolic Process RRNA Processing Nucleic Acid Metabolic Process Exosome (RNase Complex) Nucleus Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Histone MRNA Catabolic Process Nuclear Exosome (RNase Complex) Negative Regulation Of Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleolar Exosome (RNase Complex) Negative Regulation Of Macromolecule Biosynthetic Process Nuclear MRNA Surveillance Ribosome Histone MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Gene Expression RNA Processing Ribosomal Small Subunit Biogenesis Translation Regulation Of Macromolecule Metabolic Process Ribonucleoprotein Complex Nucleolus Nucleic Acid Binding Cytosolic Ribosome Positive Regulation Of MRNA Cis Splicing, Via Spliceosome 5'-3' RNA Exonuclease Activity Regulation Of Metabolic Process Nuclear RNA Surveillance RRNA Catabolic Process RNA Surveillance DNA Metabolic Process Cytosol Cytoplasmic Translation Negative Regulation Of Protein Metabolic Process Macromolecule Catabolic Process
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