UPF2 and ABCF2

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		UPF2	ABCF2
Description		UPF2 regulator of nonsense mediated mRNA decay	ATP binding cassette subfamily F member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm	Plasma Membrane Membrane
	Molecular Function	RNA Binding Protein Binding Telomeric DNA Binding	Nucleotide Binding ATP Binding ATP Hydrolysis Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration
Pathways		Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	NFE2L2 regulating MDR associated enzymes
Drugs
Diseases
GWAS		Diverticular disease ( 30177863)	Eyebrow thickness ( 26926045) Femoral neck bone mineral density ( 22504420) Height ( 31562340) IgG glycosylation ( 23382691) IgG N-glycosylation phenotypes (multivariate analysis) ( 32128391) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		78 interacting genes: ABCF2 AGPAT1 AKTIP ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 GATA3 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SSBP2 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44	4 interacting genes: ANKRD28 HADHA PTEN UPF2
Entrez ID		26019	10061
HPRD ID		10405	12403
Ensembl ID		ENSG00000151461	ENSG00000033050
Uniprot IDs		Q9HAU5	A0A090N7X1 Q9UG63
PDB IDs		1UW4 2WJV 4CEK 4CEM 7NWU 7QG6
Enriched GO Terms of Interacting Partners?		RNA Binding Nuclear-transcribed MRNA Catabolic Process RNA Catabolic Process MRNA Catabolic Process Nucleobase-containing Compound Catabolic Process RRNA Metabolic Process RRNA Processing Nucleic Acid Metabolic Process Exosome (RNase Complex) Nucleus Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Histone MRNA Catabolic Process Nuclear Exosome (RNase Complex) Negative Regulation Of Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleolar Exosome (RNase Complex) Negative Regulation Of Macromolecule Biosynthetic Process Nuclear MRNA Surveillance Ribosome Histone MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Gene Expression RNA Processing Ribosomal Small Subunit Biogenesis Translation Regulation Of Macromolecule Metabolic Process Ribonucleoprotein Complex Nucleolus Nucleic Acid Binding Cytosolic Ribosome Positive Regulation Of MRNA Cis Splicing, Via Spliceosome 5'-3' RNA Exonuclease Activity Regulation Of Metabolic Process Nuclear RNA Surveillance RRNA Catabolic Process RNA Surveillance DNA Metabolic Process Cytosol Cytoplasmic Translation Negative Regulation Of Protein Metabolic Process Macromolecule Catabolic Process	Regulation Of Cell-substrate Junction Organization Regulation Of Focal Adhesion Assembly Lipid Modification Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Regulation Of Cell-matrix Adhesion Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Acetyl-CoA C-acetyltransferase Activity Glycerophospholipid Metabolic Process (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Cardiolipin Acyl-chain Remodeling Regulation Of Cell Junction Assembly Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Regulation Of Synaptic Vesicle Clustering Regulation Of Cell-substrate Adhesion Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Phospholipid Metabolic Process Cardiolipin Metabolic Process Glycerolipid Metabolic Process Enoyl-CoA Hydratase Activity 3-hydroxyacyl-CoA Dehydratase Activity Negative Regulation Of Peptidyl-serine Phosphorylation Neuron-neuron Synaptic Transmission Negative Regulation Of Cell Size Presynaptic Membrane Organization Anaphase-promoting Complex Binding Postsynaptic Density Assembly Forebrain Morphogenesis Presynaptic Membrane Assembly Protein Serine/threonine Phosphatase Complex Locomotor Rhythm Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Postsynaptic Specialization Assembly Schmidt-Lanterman Incisure Negative Regulation Of Excitatory Postsynaptic Potential Maternal Behavior Long-chain Fatty Acyl-CoA Hydrolase Activity Phosphatidylinositol-3-phosphate Phosphatase Activity Prepulse Inhibition Meiotic Spindle Assembly
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