NCF2 and RAC2

Number of citations of the paper that reports this interaction (PubMedID 9624165)
0

Data Source:
HPRD (in vivo)

		NCF2	RAC2
Description		neutrophil cytosolic factor 2	Rac family small GTPase 2
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GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Cytosol Plasma Membrane Membrane Phagolysosome NADPH Oxidase Complex	Nuclear Envelope Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Membrane Lamellipodium Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection NADPH Oxidase Complex Extracellular Exosome
	Molecular Function	Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity Small GTPase Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Superoxide Metabolic Process Phagocytosis Cellular Defense Response Superoxide Anion Generation Innate Immune Response Respiratory Burst	Chemotaxis Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Cell Population Proliferation Regulation Of Cell Shape Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of T Cell Proliferation Superoxide Anion Generation Erythrocyte Enucleation Regulation Of Mast Cell Degranulation Bone Resorption Respiratory Burst Regulation Of Respiratory Burst Regulation Of Mast Cell Chemotaxis Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Lymphocyte Aggregation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle	GPVI-mediated activation cascade ROS and RNS production in phagocytes PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PCP/CE pathway RHO GTPases Activate NADPH Oxidases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RAC2 GTPase cycle
Drugs		Dextromethorphan	Dextromethorphan
Diseases		Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)	Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Celiac disease ( 31591516) Celiac disease and Rheumatoid arthritis ( 26546613) Systemic lupus erythematosus ( 19838195 26502338 26606652 27399966 28714469 33272962) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)	Celiac disease ( 31591516) Graves' disease ( 23612905) Longevity ( 20834067) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Type 1 diabetes ( 25751624)
Interacting Genes		15 interacting genes: AKT1 CDC42 CYBA CYBB GOLGA2 KIFAP3 NCF1 NCF4 PRDX6 PRKDC RAC1 RAC2 S100A8 S100A9 SYTL1	23 interacting genes: ACTB ADAM22 AFG3L2 AGAP2 ARFIP2 ARHGDIA ARHGDIB BRD2 CDC42 CHGB CHPF CUL1 DEF6 DOCK2 GDI1 HDAC7 ICMT NCF2 NOS2 NOXA1 RTKN SMAD1 SMAD4
Entrez ID		4688	5880
HPRD ID		01991	03628
Ensembl ID		ENSG00000116701	ENSG00000128340
Uniprot IDs		A0A0S2Z457 A0A8V8TMB9 P19878	P15153 V9H0H7
PDB IDs		1E96 1HH8 1K4U 1OEY 1WM5 2DMO 8WEJ	1DS6 2W2T 2W2V 2W2X
Enriched GO Terms of Interacting Partners?		NADPH Oxidase Complex Respiratory Burst Superoxide Anion Generation Superoxide Metabolic Process Reactive Oxygen Species Metabolic Process Regulation Of Respiratory Burst Hydrogen Peroxide Metabolic Process Hydrogen Peroxide Biosynthetic Process Superoxide-generating NAD(P)H Oxidase Activity Leukocyte Aggregation Inflammatory Response Positive Regulation Of Cell Growth Reactive Oxygen Species Biosynthetic Process Calprotectin Complex Neutrophil Aggregation Regulation Of Innate Immune Response Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Growth Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Lamellipodium Organization Cellular Response To L-glutamine Phagolysosome Peptidyl-cysteine S-nitrosylation Regulation Of Lamellipodium Assembly Regulation Of Toll-like Receptor Signaling Pathway Defense Response Erythrocyte Enucleation Toll-like Receptor 4 Binding Positive Regulation Of Cell Projection Organization Innate Immune Response Arachidonate Binding Regulation Of Lamellipodium Organization Defense Response To Fungus G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Leukocyte Cell-cell Adhesion Regulation Of Cell Growth Electron Transfer Activity Regulation Of Immune System Process Autocrine Signaling Response To Fungus Regulation Of Respiratory Burst Involved In Inflammatory Response Membrane Defense Response To Symbiont Superoxide-generating NADPH Oxidase Activator Activity Defense Response To Other Organism Protein Kinase Binding Response To Ketone Positive Regulation Of Defense Response Thioesterase Binding Chronic Inflammatory Response	Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction Small GTPase Binding Cardiac Conduction System Development Actin Cytoskeleton Organization Cytosol Rho GDP-dissociation Inhibitor Activity Intracellular Signal Transduction Actin Filament-based Process GTPase Activator Activity Superoxide Metabolic Process SMAD Protein Complex Heteromeric SMAD Protein Complex Superoxide-generating NADPH Oxidase Activator Activity Cardiac Muscle Tissue Development Rho Protein Signal Transduction I-SMAD Binding NADPH Oxidase Complex Protein Kinase Binding Cytoplasm Reactive Oxygen Species Metabolic Process GTP-dependent Protein Binding Superoxide Anion Generation SMAD Protein Signal Transduction Negative Regulation Of Protein Catabolic Process Cortical Cytoskeleton Regulation Of Small GTPase Mediated Signal Transduction Striated Muscle Tissue Development Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Establishment Or Maintenance Of Cell Polarity Signal Transduction GTP Binding Muscle Tissue Development Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis S-adenosylmethioninamine Metabolic Process Protein C-terminal S-isoprenylcysteine Carboxyl O-methyltransferase Activity
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