RAC2 and AGAP2

Number of citations of the paper that reports this interaction (PubMedID 22453919)
69

Data Source:
BioGRID (two hybrid)

		RAC2	AGAP2
Description		Rac family small GTPase 2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
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GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Membrane Lamellipodium Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection NADPH Oxidase Complex Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Membrane Extracellular Exosome Flemming Body
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein Kinase Regulator Activity Protein Kinase Binding	Nucleotide Binding GTPase Activity GTPase Activator Activity Protein Binding ATP Binding GTP Binding Zinc Ion Binding Protein Kinase Binding Protein Kinase Activator Activity Phosphatidylinositol 3-kinase Regulator Activity Metal Ion Binding Phosphatidylinositol 3-kinase Activator Activity
	Biological Process	Chemotaxis Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Cell Population Proliferation Regulation Of Cell Shape Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of T Cell Proliferation Superoxide Anion Generation Erythrocyte Enucleation Regulation Of Mast Cell Degranulation Bone Resorption Respiratory Burst Regulation Of Respiratory Burst Regulation Of Mast Cell Chemotaxis Mast Cell Proliferation Positive Regulation Of Mast Cell Proliferation Lymphocyte Aggregation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Positive Regulation Of Protein Targeting To Mitochondrion	Protein Transport Endosomal Transport Actin Cytoskeleton Organization Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Kinase Activity
Pathways		GPVI-mediated activation cascade ROS and RNS production in phagocytes PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PCP/CE pathway RHO GTPases Activate NADPH Oxidases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RAC2 GTPase cycle	Netrin-1 signaling
Drugs		Dextromethorphan
Diseases		Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Celiac disease ( 31591516) Graves' disease ( 23612905) Longevity ( 20834067) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Type 1 diabetes ( 25751624)	Heel bone mineral density ( 30598549) Multiple sclerosis ( 21833088)
Interacting Genes		23 interacting genes: ACTB ADAM22 AFG3L2 AGAP2 ARFIP2 ARHGDIA ARHGDIB BRD2 CDC42 CHGB CHPF CUL1 DEF6 DOCK2 GDI1 HDAC7 ICMT NCF2 NOS2 NOXA1 RTKN SMAD1 SMAD4	17 interacting genes: AKT1 ARF1 BTG3 CDC42 CDK4 EPB41L1 GRIP1 HOMER1 HOMER2 NF2 PIK3R1 PLCG1 PRKAA1 RAC1 RAC2 RHOA TBK1
Entrez ID		5880	116986
HPRD ID		03628	05687
Ensembl ID		ENSG00000128340	ENSG00000135439
Uniprot IDs		P15153 V9H0H7	Q99490
PDB IDs		1DS6 2W2T 2W2V 2W2X	2BMJ 2IWR 2RLO
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction Small GTPase Binding Cardiac Conduction System Development Actin Cytoskeleton Organization Cytosol Rho GDP-dissociation Inhibitor Activity Intracellular Signal Transduction Actin Filament-based Process GTPase Activator Activity Superoxide Metabolic Process SMAD Protein Complex Heteromeric SMAD Protein Complex Superoxide-generating NADPH Oxidase Activator Activity Cardiac Muscle Tissue Development Rho Protein Signal Transduction I-SMAD Binding NADPH Oxidase Complex Protein Kinase Binding Cytoplasm Reactive Oxygen Species Metabolic Process GTP-dependent Protein Binding Superoxide Anion Generation SMAD Protein Signal Transduction Negative Regulation Of Protein Catabolic Process Cortical Cytoskeleton Regulation Of Small GTPase Mediated Signal Transduction Striated Muscle Tissue Development Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Establishment Or Maintenance Of Cell Polarity Signal Transduction GTP Binding Muscle Tissue Development Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis S-adenosylmethioninamine Metabolic Process Protein C-terminal S-isoprenylcysteine Carboxyl O-methyltransferase Activity	Intracellular Signaling Cassette Intracellular Signal Transduction Lamellipodium Regulation Of Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Lamellipodium Assembly Regulation Of Transport Regulation Of Stress Fiber Assembly Positive Regulation Of Lamellipodium Organization Regulation Of Actin Filament-based Process Regulation Of Cell-substrate Adhesion Regulation Of Lamellipodium Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Cell Projection Organization Cytosol Membrane Invagination Regulation Of Actin Filament Organization Dendrite Regulation Of Lamellipodium Organization Positive Regulation Of Stress Fiber Assembly Cytoplasm Positive Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Adhesion Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Vesicle-mediated Transport Regulation Of Organelle Organization Positive Regulation Of Cell Migration Regulation Of Cell Population Proliferation Positive Regulation Of Cell Motility Positive Regulation Of Cell Projection Organization Cell Projection Actin Cytoskeleton Organization Positive Regulation Of Locomotion Signal Transduction Regulation Of Supramolecular Fiber Organization Apical Part Of Cell Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Migration Actin Filament-based Process Regulation Of Leukocyte Migration Positive Regulation Of Immune System Process Postsynapse Regulation Of Cell Projection Assembly Regulation Of Cell Motility Ruffle Membrane G Protein-coupled Glutamate Receptor Binding Regulation Of Cellular Component Organization Protein Kinase Binding Regulation Of Locomotion
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