MYOC and GGTLC1

Number of citations of the paper that reports this interaction (PubMedID 16289162)
0

Data Source:
HPRD (two hybrid)

		MYOC	GGTLC1
Description		myocilin	gamma-glutamyltransferase light chain 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Membrane Cytoplasmic Vesicle Node Of Ranvier Cell Projection Extracellular Exosome
	Molecular Function	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding Metal Ion Binding	Protein Binding Glutathione Hydrolase Activity
	Biological Process	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Signal Transduction Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of JNK Cascade Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Glutathione Catabolic Process Leukotriene D4 Biosynthetic Process
Pathways
Drugs
Diseases		Primary open angle glaucoma
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Glaucoma (primary open-angle) ( 33627673) Intake of total sugars ( 31005972)	Erectile dysfunction and prostate cancer treatment ( 20932654)
Interacting Genes		41 interacting genes: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 SGTA TGFBR1 TIMP1 TKT TNFRSF1A	1 interacting genes: MYOC
Entrez ID		4653	92086
HPRD ID		03387	17037
Ensembl ID		ENSG00000034971	ENSG00000149435
Uniprot IDs		A0A0S2Z421 Q99972	Q9BX51
PDB IDs		4WXQ 4WXS 4WXU 6OU0 6OU1 6OU2 6OU3 6PKD 6PKE 6PKF 7SIB 7SIJ 7SJT 7SJU 7SJV 7SJW 7SKD 7SKE 7SKF 7SKG 7T8D 8FRR
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Extracellular Space Extracellular Region Basement Membrane Extracellular Matrix Vesicle Glycolytic Process ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Protease Binding ADP Metabolic Process Ribonucleoside Diphosphate Catabolic Process Morphogenesis Of A Polarized Epithelium Nucleoside Diphosphate Catabolic Process Nicotinamide Nucleotide Metabolic Process Blood Microparticle Pyruvate Metabolic Process Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Nucleotide Catabolic Process Nucleotide Catabolic Process Pyruvate Kinase Activity Carbohydrate Catabolic Process Extracellular Matrix Structural Constituent Nucleoside Phosphate Catabolic Process Collagen Fibril Organization Animal Organ Development Platelet Alpha Granule Lumen Integrin Binding Cell Adhesion Wound Healing Regulation Of Transepithelial Transport Cell-substrate Adhesion ATP Metabolic Process Heart Development Hexose Metabolic Process Tissue Morphogenesis Actin Cytoskeleton Dense Body Regulation Of Multicellular Organismal Process Organophosphate Catabolic Process Monosaccharide Metabolic Process Regulation Of Cell Migration Carbohydrate Derivative Catabolic Process Generation Of Precursor Metabolites And Energy Integrin-mediated Signaling Pathway Monocarboxylic Acid Metabolic Process Lung Development Tumor Necrosis Factor Binding	Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Myosin Light Chain Binding Positive Regulation Of Mitochondrial Depolarization Clustering Of Voltage-gated Sodium Channels Skeletal Muscle Adaptation Neuronal Ion Channel Clustering Rough Endoplasmic Reticulum Fibronectin Binding Positive Regulation Of Membrane Depolarization Node Of Ranvier Negative Regulation Of Actin Filament Bundle Assembly Frizzled Binding Negative Regulation Of Rho Protein Signal Transduction ERBB2 Signaling Pathway Muscle Hypertrophy Regulation Of Mitochondrial Depolarization Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Myelination In Peripheral Nervous System Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Membrane Depolarization Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Cell-matrix Adhesion Receptor Tyrosine Kinase Binding Negative Regulation Of Cell-substrate Adhesion Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Mitochondrial Membrane Potential Regulation Of Focal Adhesion Assembly Bone Development Regulation Of Cell-substrate Junction Organization ERBB Signaling Pathway Mitochondrial Intermembrane Space Regulation Of Rho Protein Signal Transduction Regulation Of Stress Fiber Assembly Myelination Axon Ensheathment Positive Regulation Of JNK Cascade Positive Regulation Of Cell Junction Assembly Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Osteoblast Differentiation Regulation Of JNK Cascade Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization
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