MYOC and LAMA5

Number of citations of the paper that reports this interaction (PubMedID 16289162)
0

Data Source:
HPRD (two hybrid)

		MYOC	LAMA5
Description		myocilin	laminin subunit alpha 5
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Membrane Cytoplasmic Vesicle Node Of Ranvier Cell Projection Extracellular Exosome	Extracellular Region Basement Membrane Laminin-5 Complex Extracellular Space Nucleus Extracellular Matrix Neuromuscular Junction Synaptic Cleft Laminin-10 Complex Laminin-11 Complex Extracellular Exosome Extracellular Matrix Of Synaptic Cleft Glutamatergic Synapse
	Molecular Function	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding Metal Ion Binding	Signaling Receptor Binding Integrin Binding Extracellular Matrix Structural Constituent Receptor Ligand Activity Cell Adhesion Mediator Activity
	Biological Process	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Signal Transduction Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of JNK Cascade Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Branching Involved In Ureteric Bud Morphogenesis Morphogenesis Of A Polarized Epithelium Neural Crest Cell Migration Kidney Development Hair Follicle Development Cell Adhesion Integrin-mediated Signaling Pathway Muscle Organ Development Animal Organ Morphogenesis Morphogenesis Of Embryonic Epithelium Cell Migration Regulation Of Cell Adhesion Lung Development Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Trunk Neural Crest Cell Migration Odontogenesis Of Dentin-containing Tooth Regulation Of Embryonic Development Skeletal System Morphogenesis System Development Branching Morphogenesis Of An Epithelial Tube Regulation Of Epithelial Cell Proliferation Cilium Assembly Branching Involved In Salivary Gland Morphogenesis Protein Localization To Plasma Membrane Postsynapse Organization
Pathways			Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Interleukin-4 and Interleukin-13 signaling MET activates PTK2 signaling Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Drugs			Lanoteplase
Diseases		Primary open angle glaucoma
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Glaucoma (primary open-angle) ( 33627673) Intake of total sugars ( 31005972)	Colorectal cancer ( 20972440 24737748 25990418) Colorectal cancer or advanced adenoma ( 30510241) Estimated glomerular filtration rate ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Neuroblastoma (pediatric) ( 32599975) Pelvic organ prolapse ( 26545240) Plateletcrit ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		41 interacting genes: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 SGTA TGFBR1 TIMP1 TKT TNFRSF1A	17 interacting genes: ATF7IP BCAM BTBD10 COL7A1 CRKL DAG1 EDN3 FBLN2 HOXA1 LAMC1 MEP1A MTDH MYOC SMAD2 SV2A UBC USP4
Entrez ID		4653	3911
HPRD ID		03387	03020
Ensembl ID		ENSG00000034971	ENSG00000130702
Uniprot IDs		A0A0S2Z421 Q99972	O15230
PDB IDs		4WXQ 4WXS 4WXU 6OU0 6OU1 6OU2 6OU3 6PKD 6PKE 6PKF 7SIB 7SIJ 7SJT 7SJU 7SJV 7SJW 7SKD 7SKE 7SKF 7SKG 7T8D 8FRR	5XAU 7CEC
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Extracellular Space Extracellular Region Basement Membrane Extracellular Matrix Vesicle Glycolytic Process ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Protease Binding ADP Metabolic Process Ribonucleoside Diphosphate Catabolic Process Morphogenesis Of A Polarized Epithelium Nucleoside Diphosphate Catabolic Process Nicotinamide Nucleotide Metabolic Process Blood Microparticle Pyruvate Metabolic Process Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Nucleotide Catabolic Process Nucleotide Catabolic Process Pyruvate Kinase Activity Carbohydrate Catabolic Process Extracellular Matrix Structural Constituent Nucleoside Phosphate Catabolic Process Collagen Fibril Organization Animal Organ Development Platelet Alpha Granule Lumen Integrin Binding Cell Adhesion Wound Healing Regulation Of Transepithelial Transport Cell-substrate Adhesion ATP Metabolic Process Heart Development Hexose Metabolic Process Tissue Morphogenesis Actin Cytoskeleton Dense Body Regulation Of Multicellular Organismal Process Organophosphate Catabolic Process Monosaccharide Metabolic Process Regulation Of Cell Migration Carbohydrate Derivative Catabolic Process Generation Of Precursor Metabolites And Energy Integrin-mediated Signaling Pathway Monocarboxylic Acid Metabolic Process Lung Development Tumor Necrosis Factor Binding	Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Positive Regulation Of Signal Transduction Regulation Of Cell-substrate Adhesion Extracellular Matrix Constituent Conferring Elasticity Basement Membrane Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Myelination In Peripheral Nervous System Node Of Ranvier Laminin Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Cholesterol Extracellular Space Cell-substrate Adhesion Endoderm Development Positive Regulation Of Intracellular Signal Transduction Collagen Type VII Trimer Regulation Of Cell Adhesion RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Muscle Attachment Semicircular Canal Formation Skeletal Muscle Hypertrophy Adenosine Receptor Binding Regulation Of Signal Transduction Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extracellular Region Endoplasmic Reticulum Lumen Heart Development Helper T Cell Diapedesis Chordate Pharynx Development Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Cell Communication Cerebellar Neuron Development Regulation Of Intracellular Signal Transduction Receptor Tyrosine Kinase Binding Neuromuscular Junction Regulation Of Signaling Response To Transforming Growth Factor Beta Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex Nerve Maturation Positive Regulation Of Cell-matrix Adhesion Calcium-dependent Cell-matrix Adhesion Peptide Hormone Secretion Endothelin B Receptor Binding Peptide Secretion Abducens Nerve Formation
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