MYO9B and ARFGEF1

Number of citations of the paper that reports this interaction (PubMedID 15644318)
0

Data Source:
HPRD (two hybrid, in vitro)

		MYO9B	ARFGEF1
Description		myosin IXB	ARF guanine nucleotide exchange factor 1
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Filament Cell Cortex Actin Cytoskeleton Membrane Myosin Complex Lamellipodium Perinuclear Region Of Cytoplasm Postsynaptic Actin Cytoskeleton	Golgi Membrane Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Membrane Nuclear Matrix Small Nuclear Ribonucleoprotein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding GTPase Activator Activity Protein Binding Calmodulin Binding ATP Binding Zinc Ion Binding ATP Hydrolysis Activity Small GTPase Binding Protein Homodimerization Activity ADP Binding Metal Ion Binding Roundabout Binding Actin Filament Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding
	Biological Process	Signal Transduction Rho Protein Signal Transduction Actin Filament-based Movement ARF Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Roundabout Signaling Pathway Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Lamellipodium Morphogenesis	Protein Glycosylation Exocytosis Golgi Organization Endomembrane System Organization Protein Transport Negative Regulation Of Actin Filament Polymerization Neuron Projection Development Regulation Of ARF Protein Signal Transduction Negative Regulation Of GTPase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Wound Healing Regulation Of Establishment Of Cell Polarity
Pathways		Regulation of actin dynamics for phagocytic cup formation RHOA GTPase cycle SLIT2:ROBO1 increases RHOA activity RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOF GTPase cycle FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		A body shape index ( 34021172) Appendicular lean mass ( 33097823) Asthma ( 32296059) Coronary artery disease ( 33020668 29212778) Diastolic blood pressure ( 27841878) Glycated hemoglobin levels ( 24647736 28898252 34059833) Height ( 31562340 29782485 20881960) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494 27863252 29403010) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Night sleep phenotypes ( 27126917) Platelet count ( 29403010 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Prostate cancer ( 29892016) Prostate cancer (early onset) ( 29892016) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Selective IgA deficiency ( 27723758) Spleen volume ( 34128465) Systolic blood pressure ( 30578418 27841878) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 28552196)	Chronic central serous retinopathy ( 30073298) Hearing function ( 25060954) Hip circumference adjusted for BMI ( 28552196)
Interacting Genes		7 interacting genes: ACTA1 ARFGEF1 CALM1 LRRC41 MOB4 PKN2 RAB8A	6 interacting genes: ARFGEF2 CTNNB1 DPY30 FKBP2 LYN MYO9B
Entrez ID		4650	10565
HPRD ID		03677	09163
Ensembl ID		ENSG00000099331	ENSG00000066777
Uniprot IDs		B0I1T6 Q13459 Q8WVD2	Q9Y6D6
PDB IDs		5C5S 5HPY	3LTL 5EE5 5J5C
Enriched GO Terms of Interacting Partners?		Myosin Binding Cytoplasm Cytoskeleton Lamellipodium Sarcomere Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of Synaptic Plasticity Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Membrane Docking Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cell Division Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Regulation Of Cytokinesis Centrosome Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Vesicle-mediated Transport In Synapse Organelle Localization By Membrane Tethering Golgi Vesicle Fusion To Target Membrane Golgi Organization Midbody Exocytosis Perinuclear Region Of Cytoplasm Endomembrane System Organization Negative Regulation Of Voltage-gated Calcium Channel Activity Apical Junction Assembly Striated Muscle Thin Filament Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Neurotransmitter Receptor Transport To Postsynaptic Membrane Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane	Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Mesenchymal Stem Cell Differentiation Oviduct Development Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Hemopoiesis Negative Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Gliogenesis Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Beta-catenin-ICAT Complex Intracellular Signal Transduction Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Acinar Cell Differentiation Positive Regulation Of Proteoglycan Biosynthetic Process Negative Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Neural Precursor Cell Proliferation Regulation Of Timing Of Anagen Lamellipodium Fungiform Papilla Formation Negative Regulation Of Myeloid Cell Differentiation Myeloid Leukocyte Differentiation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Transmembrane Transporter Binding Beta-catenin-TCF7L2 Complex Cellular Response To Indole-3-methanol Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Perinuclear Region Of Cytoplasm Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Central Nervous System Vasculogenesis Hemopoiesis Metanephros Morphogenesis Trachea Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Cell Cortex Cranial Ganglion Development Regulation Of Centriole-centriole Cohesion Adherens Junction Renal Outer Medulla Development Regulation Of Myeloid Leukocyte Differentiation Renal Vesicle Formation Embryonic Skeletal Limb Joint Morphogenesis Glial Cell-neuron Signaling Lung Induction Regulation Of Centromeric Sister Chromatid Cohesion Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Cell Morphogenesis Positive Regulation Of Branching Involved In Lung Morphogenesis
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