GADD45B and MAP2K7

Number of citations of the paper that reports this interaction (PubMedID 14743220)
0

Data Source:
HPRD (in vitro, in vivo)

		GADD45B	MAP2K7
Description		growth arrest and DNA damage inducible beta	mitogen-activated protein kinase kinase 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Kinase Activity Transferase Activity Enzyme Binding Protein Kinase Binding Protein Phosphatase Binding Metal Ion Binding Protein Serine Kinase Activity Molecular Function Activator Activity
	Biological Process	Apoptotic Process Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of P38MAPK Cascade	Apoptotic Process Response To Osmotic Stress Signal Transduction JNK Cascade Response To Heat Response To UV Response To Wounding Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Telomere Maintenance Response To Tumor Necrosis Factor Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Stress-activated MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Senescence Regulation Of Motor Neuron Apoptotic Process
Pathways			Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins
Drugs			Pimasertib
Diseases
GWAS			Appendicular lean mass ( 33097823) Fasting insulin ( 34059833) HDL cholesterol levels ( 32203549) Mean corpuscular hemoglobin concentration ( 32888494) Metabolite levels ( 23823483) Type 2 diabetes ( 30297969 32499647)
Interacting Genes		17 interacting genes: CCNB1 CDK1 CDKN1A CFTR CNOT9 EFHC1 ESR1 GADD45G GADD45GIP1 MAP2K7 MAP3K4 MAP3K5 NFIX PCNA PPARA PPARD PPARG	34 interacting genes: ARR3 ATF4 CEBPA CFLAR CNKSR1 DUSP19 DUSP22 GADD45B ICAM1 JUN LPXN LRRK2 MAP3K1 MAP3K11 MAP3K12 MAP3K13 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 MAPT RANBP2 RPL30 TRAF6 TRIB1 VRK2
Entrez ID		4616	5609
HPRD ID		05382	04309
Ensembl ID		ENSG00000099860	ENSG00000076984
Uniprot IDs		O75293	B4DV95 O14733
PDB IDs			2DYL 3WZU 4UX9 5B2K 5B2L 5B2M 5Y8U 5Y90 5Z1D 5Z1E 6IB0 6IB2 6QFL 6QFR 6QFT 6QG4 6QG7 6QHO 6QHR 6YFZ 6YG0 6YG1 6YG2 6YG3 6YG4 6YG5 6YG6 6YG7 6YZ4 7CBX 7OVI 7OVJ 7OVK 7OVL 7OVM 7OVN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of MiRNA Transcription Positive Regulation Of Metabolic Process Negative Regulation Of Cholesterol Storage Nuclear Receptor Activity Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Cyclin B1-CDK1 Complex PCNA-p21 Complex Regulation Of MiRNA Transcription Nuclear Steroid Receptor Activity Negative Regulation Of Lipid Storage Response To Wounding Regulation Of MiRNA Metabolic Process Positive Regulation Of P38MAPK Cascade Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Rhythmic Process Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Response To Lipid Positive Regulation Of DNA Metabolic Process Positive Regulation Of Fatty Acid Metabolic Process Fibroblast Proliferation Positive Regulation Of DNA Replication Regulation Of P38MAPK Cascade Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Developmental Growth Cyclin-dependent Protein Kinase Holoenzyme Complex Hormone-mediated Signaling Pathway Placenta Development Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Biosynthetic Process Regulation Of Lipid Storage Cellular Developmental Process Response To UV Intracellular Signal Transduction Transcription Coactivator Binding Positive Regulation Of RNA Metabolic Process Reproductive Process Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Apoptotic Process Cellular Senescence Enzyme Binding Regulation Of Gene Expression Regulation Of Heart Growth Negative Regulation Of Macromolecule Metabolic Process	MAPK Cascade MAP Kinase Kinase Kinase Activity Intracellular Signaling Cassette JNK Cascade Regulation Of MAPK Cascade Protein Serine Kinase Activity Positive Regulation Of MAPK Cascade Intracellular Signal Transduction Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Intracellular Signal Transduction Kinase Activity Regulation Of JNK Cascade Signal Transduction Regulation Of Signal Transduction Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JNK Cascade Regulation Of Cell Communication Regulation Of Signaling Protein Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Phosphorylation Positive Regulation Of Signal Transduction Protein Kinase Binding Cytoplasm JUN Kinase Kinase Kinase Activity ATP Binding Regulation Of Apoptotic Process Protein Autophosphorylation Regulation Of Programmed Cell Death Transferase Activity MAP-kinase Scaffold Activity Cellular Response To Stress MAP Kinase Activity Positive Regulation Of Programmed Cell Death Fc-epsilon Receptor Signaling Pathway Cellular Response To Oxidative Stress P38MAPK Cascade Regulation Of MAP Kinase Activity Positive Regulation Of P38MAPK Cascade Nucleotide Binding Positive Regulation Of Apoptotic Process Regulation Of Immune System Process Cellular Response To Chemical Stress Mitogen-activated Protein Kinase Kinase Binding Protein Modification Process Integrated Stress Response Signaling
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