MUSK and COLQ

Number of citations of the paper that reports this interaction (PubMedID 15159418)
44

Data Source:
HPRD (in vivo)

		MUSK	COLQ
Description		muscle associated receptor tyrosine kinase	collagen like tail subunit of asymmetric acetylcholinesterase
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GO Annotations	Cellular Component	Plasma Membrane Membrane Neuromuscular Junction Receptor Complex Synapse Postsynaptic Membrane	Collagen Trimer Basement Membrane Extracellular Space Plasma Membrane Cell Junction Extracellular Matrix Neuromuscular Junction Synaptic Cleft Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Wnt-protein Binding Metal Ion Binding	Extracellular Matrix Structural Constituent Protein Binding Heparin Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuromuscular Junction Development Memory Regulation Of Synaptic Assembly At Neuromuscular Junction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Cell Differentiation Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Protein Geranylgeranylation	Acetylcholine Catabolic Process In Synaptic Cleft Regulation Of Synaptic Assembly At Neuromuscular Junction Skeletal Muscle Acetylcholine-gated Channel Clustering Establishment Of Protein Localization To Membrane
Pathways		ECM proteoglycans
Drugs		Fostamatinib
Diseases		Congenital myasthenic syndrome	Congenital myasthenic syndrome
GWAS		Body mass index ( 28552196) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Orofacial cleft x maternal periconceptional smoking interaction (1df) ( 33937227) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Pulmonary function decline ( 22424883) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)	Diverticular disease ( 28585551 30177863) Diverticulitis ( 28585551)
Interacting Genes		7 interacting genes: COLQ DOK7 ERBIN ILKAP RAPSN STYX SYNE1	6 interacting genes: ACHE BCHE MRPS25 MUSK SGTB SNCA
Entrez ID		4593	8292
HPRD ID		03190	04328
Ensembl ID		ENSG00000030304	ENSG00000206561
Uniprot IDs		A0A087WSY1 O15146	Q9Y215
PDB IDs		8S9P	1VZJ
Enriched GO Terms of Interacting Partners?		Neuromuscular Junction Receptor Clustering Skeletal Muscle Acetylcholine-gated Channel Clustering Neuromuscular Junction Development Postsynaptic Membrane Protein Localization To Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Negative Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Structural Constituent Of Postsynaptic Specialization Positive Regulation Of Motor Neuron Apoptotic Process Pseudophosphatase Activity Acetylcholine Catabolic Process In Synaptic Cleft Basement Membrane Basal Protein Localization Localization Within Membrane Positive Regulation Of Neuromuscular Synaptic Transmission F-box Domain Binding Acetylcholine Catabolic Process Nuclear Matrix Anchoring At Nuclear Membrane ErbB-2 Class Receptor Binding Regulation Of Postsynaptic Membrane Organization Nuclear Matrix Organization Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cytoskeleton-nuclear Membrane Anchor Activity Negative Regulation Of Monocyte Chemotactic Protein-1 Production Cell Junction Establishment Of Protein Localization To Membrane Intracellular Protein Localization Hemidesmosome Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Protein Tyrosine Kinase Activity Maintenance Of Postsynaptic Specialization Structure Regulation Of Synaptic Assembly At Neuromuscular Junction Meiotic Nuclear Membrane Microtubule Tethering Complex Establishment Of Protein Localization To Postsynaptic Membrane Synapse Organization Postsynaptic Specialization Synapse Nuclear Membrane Positive Regulation Of Receptor Clustering Acetylcholine Receptor Binding Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cation Binding Lamin Binding Regulation Of Receptor Clustering Positive Regulation Of Rac Protein Signal Transduction Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane	Acetylcholine Catabolic Process Acetylcholinesterase Activity Cholinesterase Activity Regulation Of Receptor Recycling Carboxylic Ester Hydrolase Activity Negative Regulation Of Synaptic Transmission Synapse Organization Hsp70 Protein Binding Negative Regulation Of Synaptic Transmission, Cholinergic Receptor Internalization Neuromuscular Junction Cocaine Metabolic Process Positive Regulation Of Protein Geranylgeranylation Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cell Junction Organization Amyloid-beta Binding Response To Alkaloid Modulation Of Chemical Synaptic Transmission Acetylcholine Catabolic Process In Synaptic Cleft Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process TRC Complex Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Identical Protein Binding Choline Binding Regulation Of Synapse Assembly Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Receptor-mediated Endocytosis Ribosome Molecular Adaptor Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Serine Hydrolase Activity Choline Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Neuroblast Differentiation Response To Iron(II) Ion Acetylcholine Binding Synapse Alkaloid Metabolic Process Skeletal Muscle Acetylcholine-gated Channel Clustering Mitochondrial ATP Synthesis Coupled Electron Transport
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