MUSK and DOK7

Number of citations of the paper that reports this interaction (PubMedID 16917026)
0

Data Source:
HPRD (in vivo)

		MUSK	DOK7
Description		muscle associated receptor tyrosine kinase	docking protein 7
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Neuromuscular Junction Receptor Complex Synapse Postsynaptic Membrane	Nucleoplasm Mitochondrion Plasma Membrane Membrane Neuromuscular Junction Synapse Postsynaptic Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Wnt-protein Binding Metal Ion Binding	Protein Binding Lipid Binding Protein Kinase Binding Phosphatidylinositol Binding Signaling Adaptor Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuromuscular Junction Development Memory Regulation Of Synaptic Assembly At Neuromuscular Junction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Cell Differentiation Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Protein Geranylgeranylation	Enzyme-linked Receptor Protein Signaling Pathway Neuromuscular Junction Development Positive Regulation Of Rac Protein Signal Transduction Receptor Clustering Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Pathways		ECM proteoglycans
Drugs		Fostamatinib
Diseases		Congenital myasthenic syndrome	Congenital myasthenic syndrome Fetal akinesia deformation sequence (FADS); Pena-Shokeir syndrome, type 1
GWAS		Body mass index ( 28552196) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Orofacial cleft x maternal periconceptional smoking interaction (1df) ( 33937227) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Pulmonary function decline ( 22424883) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)	Calcium levels ( 29403010) Coronary artery disease ( 33020668) Fibrinogen levels ( 28107422) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Spondylosis ( 33332786)
Interacting Genes		7 interacting genes: COLQ DOK7 ERBIN ILKAP RAPSN STYX SYNE1	8 interacting genes: APPL1 BCAR1 CRK EFEMP2 EFHC1 MPZL1 MUSK YPEL3
Entrez ID		4593	285489
HPRD ID		03190	08744
Ensembl ID		ENSG00000030304	ENSG00000175920
Uniprot IDs		A0A087WSY1 O15146	A0A1W2PRA3 A0A2R8Y701 Q18PE1 Q8N1M3
PDB IDs		8S9P
Enriched GO Terms of Interacting Partners?		Neuromuscular Junction Receptor Clustering Skeletal Muscle Acetylcholine-gated Channel Clustering Neuromuscular Junction Development Postsynaptic Membrane Protein Localization To Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Negative Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Structural Constituent Of Postsynaptic Specialization Positive Regulation Of Motor Neuron Apoptotic Process Pseudophosphatase Activity Acetylcholine Catabolic Process In Synaptic Cleft Basement Membrane Basal Protein Localization Localization Within Membrane Positive Regulation Of Neuromuscular Synaptic Transmission F-box Domain Binding Acetylcholine Catabolic Process Nuclear Matrix Anchoring At Nuclear Membrane ErbB-2 Class Receptor Binding Regulation Of Postsynaptic Membrane Organization Nuclear Matrix Organization Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cytoskeleton-nuclear Membrane Anchor Activity Negative Regulation Of Monocyte Chemotactic Protein-1 Production Cell Junction Establishment Of Protein Localization To Membrane Intracellular Protein Localization Hemidesmosome Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Protein Tyrosine Kinase Activity Maintenance Of Postsynaptic Specialization Structure Regulation Of Synaptic Assembly At Neuromuscular Junction Meiotic Nuclear Membrane Microtubule Tethering Complex Establishment Of Protein Localization To Postsynaptic Membrane Synapse Organization Postsynaptic Specialization Synapse Nuclear Membrane Positive Regulation Of Receptor Clustering Acetylcholine Receptor Binding Regulation Of Motor Neuron Apoptotic Process Motor Neuron Apoptotic Process Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cation Binding Lamin Binding Regulation Of Receptor Clustering Positive Regulation Of Rac Protein Signal Transduction Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane	Response To Hepatocyte Growth Factor Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Cellular Response To Growth Factor Stimulus Actin Cytoskeleton Response To Growth Factor Positive Regulation Of Protein Geranylgeranylation Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Smooth Muscle Cell-matrix Adhesion Neuromuscular Junction Insulin Receptor Signaling Pathway Helper T Cell Diapedesis Cell Surface Receptor Signaling Pathway Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Positive Regulation Of Macropinocytosis Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Ruffle SH3 Domain Binding Cerebellar Neuron Development Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Collagen Fibril Organization Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Growth Regulation Of Cellular Component Organization Macropinosome Elastic Fiber Regulation Of Protein Localization To Membrane Aorta Smooth Muscle Tissue Morphogenesis Diapedesis Positive Regulation Of Pinocytosis Cell Chemotaxis Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Cellular Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Reelin-mediated Signaling Pathway Response To Endothelin Cellular Response To Endothelin Regulation Of Cell-substrate Adhesion Postsynaptic Specialization Assembly Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Synaptic Assembly At Neuromuscular Junction Endothelin Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Early Phagosome Positive Regulation Of Melanin Biosynthetic Process Protein Kinase B Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
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