MT-CO2 and ECT2

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid)

		MT-CO2	ECT2
Description		cytochrome c oxidase subunit II	epithelial cell transforming 2
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Mitochondrial Membrane Respiratory Chain Complex IV	Nucleus Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Cell-cell Junction Bicellular Tight Junction Cell Cortex Nuclear Body Midbody Cleavage Furrow Anchoring Junction Mitotic Spindle Centralspindlin Complex
	Molecular Function	Cytochrome-c Oxidase Activity Copper Ion Binding Protein Binding Oxidoreductase Activity Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity
	Biological Process	Response To Hypoxia Mitochondrial Electron Transport, Cytochrome C To Oxygen Lactation Electron Transport Chain ATP Synthesis Coupled Electron Transport Cellular Respiration Response To Ethanol Proton Transmembrane Transport	Mitotic Cytokinesis Cell Morphogenesis Nervous System Development Protein Transport Cell Differentiation Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Bicellular Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Activation Of GTPase Activity Positive Regulation Of Mitotic Cytokinetic Process Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly
Pathways		Mitochondrial translation termination TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Mitochondrial protein degradation Complex IV assembly	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs		Cholic Acid N-Formylmethionine Talmapimod
Diseases
GWAS			Obesity-related traits ( 23251661) Red cell distribution width ( 32888494)
Interacting Genes		11 interacting genes: CCNG1 ECT2 EGFR HSPB2 LIG4 PSMA1 RAD21 RIDA SHANK3 VHL YWHAE	39 interacting genes: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 CSTB EIF4A2 EIF5B ELOC ERAL1 F2RL2 FANCM GGN HACL2 KLHL20 LAMTOR5 MBD1 MT-CO2 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 SRPK2 THAP11 UBB USP7 VDAC2
Entrez ID		4513	1894
HPRD ID		02470	11860
Ensembl ID		ENSG00000198712	ENSG00000114346
Uniprot IDs		P00403 U5Z487	Q9H8V3
PDB IDs		3VRJ 5Z62	3L46 4N40 6L30
Enriched GO Terms of Interacting Partners?		Cell Division Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Cell Morphogenesis Nucleus Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Positive Regulation Of Cell Cycle Process Positive Regulation Of Fibroblast Proliferation Multivesicular Body, Internal Vesicle Lumen MAPK Cascade Establishment Of Integrated Proviral Latency 2-iminopropanoate Deaminase Activity 2-iminobutanoate/2-iminopropanoate Deaminase L-threonine Catabolic Process To Glycine RNA Endonuclease Activity Producing 3'-phosphomonoesters, Hydrolytic Mechanism 2-iminobutanoate Deaminase Activity Positive Regulation Of Nucleocytoplasmic Transport Cytoplasm Regulation Of Protein Phosphorylation Centralspindlin Complex Cellular Response To Stress Cellular Response To Ionizing Radiation Positive Regulation Of Cell Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of Intracellular Protein Transport Regulation Of Cell Differentiation Cytosol Enzyme Binding Protein Phosphatase Binding Positive Regulation Of Protein Kinase C Signaling Regulation Of Fibroblast Proliferation Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Response To Heat DNA Ligase (ATP) Activity DNA Ligase IV Complex Establishment Of Viral Latency DNA Ligase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Establishment Of Meiotic Sister Chromatid Cohesion Regulation Of Heart Rate By Hormone Scaffold Protein Binding L-threonine Catabolic Process Threonine Metabolic Process Guanylate Kinase-associated Protein Clustering Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Positive Regulation Of Chromosome Organization	Cytosol Positive Regulation Of Protein Monoubiquitination Regulation Of Protein Monoubiquitination
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