ECT2 and SPATA22

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid)

		ECT2	SPATA22
Description		epithelial cell transforming 2	spermatogenesis associated 22
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Cell-cell Junction Bicellular Tight Junction Cell Cortex Nuclear Body Midbody Cleavage Furrow Anchoring Junction Mitotic Spindle Centralspindlin Complex	Chromosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Mitotic Cytokinesis Cell Morphogenesis Nervous System Development Protein Transport Cell Differentiation Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Bicellular Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Activation Of GTPase Activity Positive Regulation Of Mitotic Cytokinetic Process Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly	Meiotic DNA Repair Synthesis Homologous Chromosome Pairing At Meiosis Gamete Generation Fertilization Spermatocyte Division Meiotic Cell Cycle Regulation Of Meiotic Cell Cycle Reproductive System Development
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Red cell distribution width ( 32888494)	Caudal middle frontal gyrus volume ( 31530798)
Interacting Genes		39 interacting genes: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 CSTB EIF4A2 EIF5B ELOC ERAL1 F2RL2 FANCM GGN HACL2 KLHL20 LAMTOR5 MBD1 MT-CO2 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 SRPK2 THAP11 UBB USP7 VDAC2	7 interacting genes: ECT2 FAM107A GOLGA2 HSF2BP KDM1A PRMT6 VHL
Entrez ID		1894	84690
HPRD ID		11860	14862
Ensembl ID		ENSG00000114346	ENSG00000141255
Uniprot IDs		Q9H8V3	A0A140VJV9 B4DHW8 F5GWB9 Q8NHS9
PDB IDs		3L46 4N40 6L30
Enriched GO Terms of Interacting Partners?		Cytosol Positive Regulation Of Protein Monoubiquitination Regulation Of Protein Monoubiquitination	Positive Regulation Of Protein Modification Process Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Cellular Response To Ionizing Radiation Negative Regulation Of Catabolic Process Histone H2AR3 Methyltransferase Activity Negative Regulation Of Autophagy Positive Regulation Of Protein Ubiquitination Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Centralspindlin Complex Positive Regulation Of Post-translational Protein Modification Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone Arginine N-methyltransferase Activity Mitotic Spindle Response To Ionizing Radiation Positive Regulation Of Mitotic Cytokinetic Process Protein Homooligomerization Regulation Of Primary Metabolic Process Cellular Response To Radiation Cellular Response To Stress Cell Morphogenesis Regulation Of Cell Differentiation Positive Regulation Of Protein Glycosylation Regulation Of Protein Glycosylation Golgi Disassembly DNA-binding Transcription Factor Binding Female Meiosis I Regulation Of Protein Ubiquitination Response To Fungicide MRF Binding Guanine Metabolic Process Protein Demethylase Activity Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Positive Regulation Of Macromolecule Metabolic Process Transcription Elongation Factor Activity Histone H3K4 Demethylase Activity Positive Regulation Of Cell Differentiation Golgi Ribbon Formation Importin-alpha Family Protein Binding Double-strand Break Repair Involved In Meiotic Recombination Regulation Of Post-translational Protein Modification Histone H3K9 Demethylase Activity Protein-arginine N-methyltransferase Activity
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