CCDC88C and MPDZ

Number of citations of the paper that reports this interaction (PubMedID 31268831)
39

Data Source:
BioGRID (pull down)

		CCDC88C	MPDZ
Description		coiled-coil and HOOK domain protein 88C	multiple PDZ domain crumbs cell polarity complex component
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Centrosome Cell Junction Apical Junction Complex Anchoring Junction	Cytoplasm Plasma Membrane Bicellular Tight Junction Postsynaptic Density Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Dendrite Cell Projection Neuron Projection Apical Part Of Cell Synapse Anchoring Junction
	Molecular Function	G-protein Alpha-subunit Binding Guanyl-nucleotide Exchange Factor Activity Frizzled Binding Protein Binding Microtubule Binding PDZ Domain Binding Identical Protein Binding Protein Dimerization Activity Dynein Light Intermediate Chain Binding	Protein Binding
	Biological Process	Microtubule Bundle Formation Cilium Movement Apical Constriction Negative Regulation Of Microtubule Depolymerization Signal Transduction Small GTPase-mediated Signal Transduction Wnt Signaling Pathway Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Protein Destabilization Non-canonical Wnt Signaling Pathway Cilium Organization Positive Regulation Of JNK Cascade Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Mucociliary Clearance Respiratory Basal Cell Differentiation	Tight Junction Assembly
Pathways		Negative regulation of TCF-dependent signaling by DVL-interacting proteins
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Breast cancer ( 23535729 29059683) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Daytime sleep phenotypes ( 27126917) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Appendicular lean mass ( 33097823) Central corneal thickness ( 29760442 32528159) Corneal hysteresis ( 30894546 32716492) Corneal structure ( 23291589) Heel bone mineral density ( 28869591 30598549) Refractive astigmatism ( 30306274) Triglyceride levels ( 32203549)
Interacting Genes		11 interacting genes: APP DVL1 FBXO7 FZD6 FZD7 GNAI3 ITSN2 MAPK8 MPDZ TAFAZZIN TSC22D1	19 interacting genes: ABCA1 CAMK2A CCDC88C CLDN1 CLDN5 CRHR1 CSPG4 DRD3 F11R HTR2C KIT MTNR1A PELI2 PLEKHA1 PLEKHA2 RNF5 SYNGAP1 TSC22D2 VANGL2
Entrez ID		440193	8777
HPRD ID		19136	09155
Ensembl ID		ENSG00000015133	ENSG00000107186
Uniprot IDs		B4DZB8 Q9P219	O75970
PDB IDs			2FCF 2FNE 2IWN 2IWO 2IWP 2IWQ 2O2T 2OPG 2QG1
Enriched GO Terms of Interacting Partners?		Frizzled Binding Wnt Signaling Pathway, Planar Cell Polarity Pathway Non-canonical Wnt Signaling Pathway Positive Regulation Of Catabolic Process Canonical Wnt Signaling Pathway Collateral Sprouting Wnt Receptor Activity Neuronal Dense Core Vesicle Protein Serine/threonine Kinase Binding Apicolateral Plasma Membrane Wnt-protein Binding Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Metabolic Process Positive Regulation Of ATP Metabolic Process Regulation Of Macroautophagy Neuron Projection Organization Amyloid-beta Complex Regulation Of Canonical Wnt Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Activation Modulation Of Excitatory Postsynaptic Potential Wnt Signaling Pathway JUN Phosphorylation Negative Regulation Of Ectodermal Cell Fate Specification Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Positive Regulation Of Nucleobase-containing Compound Metabolic Process Acetylcholine Receptor Activator Activity Regulation Of Wnt Signaling Pathway Regulation Of ATP Metabolic Process Positive Regulation Of Phosphate Metabolic Process Neuron Projection Regulation Of Purine Nucleotide Metabolic Process G Protein-coupled Receptor Binding G Protein-coupled Receptor Signaling Pathway Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Protein Localization To Presynapse Positive Regulation Of Cardiolipin Metabolic Process Clathrin-dependent Synaptic Vesicle Endocytosis Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway PTB Domain Binding Axon Collateral Sprouting In Absence Of Injury Regulation Of Protein Import	Regulation Of Biological Quality Plasma Membrane Cell-cell Junction Regulation Of Bicellular Tight Junction Assembly PDZ Domain Binding Regulation Of Cell Communication Regulation Of Signaling Maintenance Of Blood-brain Barrier Tight Junction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Establishment Of Endothelial Barrier Learning Visual Learning Regulation Of Neuronal Synaptic Plasticity Visual Behavior Regulation Of MAPK Cascade Positive Regulation Of Bicellular Tight Junction Assembly Lateral Plasma Membrane Cell Junction Signal Transduction Regulation Of Cellular Component Organization Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Establishment Of Endothelial Intestinal Barrier G Protein-coupled Receptor Signaling Pathway Associative Learning Response To Alcohol Positive Regulation Of Signal Transduction Regulation Of Establishment Of Endothelial Barrier Learning Or Memory Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Plasma Membrane Bounded Cell Projection Organization Response To Ethanol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Phosphate Metabolic Process Ruffle Organization Cognition Bicellular Tight Junction Regulation Of Long-term Neuronal Synaptic Plasticity Phosphatidylinositol-3,4-bisphosphate Binding Face Morphogenesis Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Platelet-derived Growth Factor Receptor Signaling Pathway Response To Stress
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