MPDZ and PLEKHA1

Number of citations of the paper that reports this interaction (PubMedID 11802782)
40

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		MPDZ	PLEKHA1
Description		multiple PDZ domain crumbs cell polarity complex component	pleckstrin homology domain containing A1
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Bicellular Tight Junction Postsynaptic Density Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Dendrite Cell Projection Neuron Projection Apical Part Of Cell Synapse Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Phospholipid Binding Lipid Binding PDZ Domain Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Tight Junction Assembly	Luteinization Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Female Gonad Development Post-embryonic Development Ruffle Organization Leydig Cell Differentiation Multicellular Organism Growth Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Establishment Of Protein Localization Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis B Cell Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Roof Of Mouth Development Face Morphogenesis Cellular Response To Hydrogen Peroxide
Pathways			Synthesis of PIPs at the plasma membrane
Drugs			Citric acid
Diseases
GWAS		Appendicular lean mass ( 33097823) Central corneal thickness ( 29760442 32528159) Corneal hysteresis ( 30894546 32716492) Corneal structure ( 23291589) Heel bone mineral density ( 28869591 30598549) Refractive astigmatism ( 30306274) Triglyceride levels ( 32203549)	Age-related macular degeneration ( 23536807 23577725) Age-related macular degeneration (extreme sampling) ( 23577725) Appendicular lean mass ( 33097823) Autoimmune thyroid disease ( 32581359) Birth weight ( 27680694 31043758) Central corneal thickness ( 32528159) Femoral neck bone mineral density ( 29499414) Height ( 20189936 31562340) Hip circumference adjusted for BMI ( 34021172) Medication use (thyroid preparations) ( 31015401) Offspring birth weight ( 31043758) Refractive error ( 32231278) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 30718926 30297969 30054458 32499647 28869590 28566273 24509480)
Interacting Genes		19 interacting genes: ABCA1 CAMK2A CCDC88C CLDN1 CLDN5 CRHR1 CSPG4 DRD3 F11R HTR2C KIT MTNR1A PELI2 PLEKHA1 PLEKHA2 RNF5 SYNGAP1 TSC22D2 VANGL2	9 interacting genes: ATE1 CLDN14 CRKL FBXO7 MPDZ PLEKHA2 PTPN13 SH3BP4 SNTG1
Entrez ID		8777	59338
HPRD ID		09155	09686
Ensembl ID		ENSG00000107186	ENSG00000107679
Uniprot IDs		O75970	B3KQL5 Q5RGS4 Q9HB21
PDB IDs		2FCF 2FNE 2IWN 2IWO 2IWP 2IWQ 2O2T 2OPG 2QG1	1EAZ
Enriched GO Terms of Interacting Partners?		Regulation Of Biological Quality Plasma Membrane Cell-cell Junction Regulation Of Bicellular Tight Junction Assembly PDZ Domain Binding Regulation Of Cell Communication Regulation Of Signaling Maintenance Of Blood-brain Barrier Tight Junction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Establishment Of Endothelial Barrier Learning Visual Learning Regulation Of Neuronal Synaptic Plasticity Visual Behavior Regulation Of MAPK Cascade Positive Regulation Of Bicellular Tight Junction Assembly Lateral Plasma Membrane Cell Junction Signal Transduction Regulation Of Cellular Component Organization Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Establishment Of Endothelial Intestinal Barrier G Protein-coupled Receptor Signaling Pathway Associative Learning Response To Alcohol Positive Regulation Of Signal Transduction Regulation Of Establishment Of Endothelial Barrier Learning Or Memory Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Plasma Membrane Bounded Cell Projection Organization Response To Ethanol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Phosphate Metabolic Process Ruffle Organization Cognition Bicellular Tight Junction Regulation Of Long-term Neuronal Synaptic Plasticity Phosphatidylinositol-3,4-bisphosphate Binding Face Morphogenesis Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Platelet-derived Growth Factor Receptor Signaling Pathway Response To Stress	Tight Junction Assembly Tight Junction Organization Arginyl-tRNA--protein Transferase Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Helper T Cell Diapedesis Negative Regulation Of Excitatory Synapse Assembly Protein Arginylation Protein Localization To Vacuole Chordate Pharynx Development Cerebellar Neuron Development Amino Acid Import Lewy Body Core Positive Regulation Of Cell-substrate Adhesion Bicellular Tight Junction Cell-cell Junction Assembly
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