MPP1 and ACER2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MPP1	ACER2
Description		MAGUK p55 scaffold protein 1	alkaline ceramidase 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Plasma Membrane Cell-cell Junction Membrane Cortical Cytoskeleton Stereocilium Centriolar Satellite Cell Projection	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	GMP Kinase Activity Signaling Receptor Binding Protein Binding	Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides N-acylsphingosine Amidohydrolase Activity Metal Ion Binding
	Biological Process	Signal Transduction GMP Metabolic Process GDP Metabolic Process Regulation Of Neutrophil Chemotaxis	Negative Regulation Of Cell-matrix Adhesion Lipid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process DNA Damage Response Positive Regulation Of Cell Population Proliferation Regulation Of Autophagy Sphingolipid Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Retinoic Acid Negative Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Apoptotic Process Sphingosine Biosynthetic Process Ceramide Catabolic Process Regulation Of Protein Glycosylation Cellular Response To Xenobiotic Stimulus
Pathways		Sensory processing of sound by outer hair cells of the cochlea	Sphingolipid catabolism
Drugs
Diseases
GWAS		Hematology traits ( 23263863) Mean corpuscular volume ( 23263863) Red blood cell traits ( 23446634)
Interacting Genes		46 interacting genes: ABCC4 ACER1 ACER2 AGPAT3 AMOTL2 AP2M1 APH1A ATP5F1C ATRAID DERL2 DGAT2L6 DLG4 DNPEP ERBIN FXR2 GADD45A GPRASP3 GSK3B GYPC HNRNPD INCA1 KLHL12 MAP3K20 MEOX2 NR1H2 OGT OPTN PAQR8 PRIMPOL RPRM RPS6KA1 RPS6KA6 SGSM2 SLC35E1 SMN1 SRSF10 STK3 STUB1 SYNGR3 TK1 TMEM239 TRIM55 TRIM63 USP21 UXT ZNF639	1 interacting genes: MPP1
Entrez ID		4354	340485
HPRD ID		02370	16512
Ensembl ID		ENSG00000130830	ENSG00000177076
Uniprot IDs		B4E325 Q00013	B3KVV5 Q5QJU3
PDB IDs		2EJY 2EV8 3NEY
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction TOR Signaling Ribosomal Protein S6 Kinase Activity N-acylsphingosine Amidohydrolase Activity	GMP Kinase Activity GDP Metabolic Process Stereocilium Regulation Of Neutrophil Chemotaxis Cortical Cytoskeleton GMP Metabolic Process Regulation Of Neutrophil Migration Regulation Of Granulocyte Chemotaxis Nucleoside Monophosphate Metabolic Process Nucleoside Diphosphate Metabolic Process Ribonucleoside Diphosphate Metabolic Process Centriolar Satellite Regulation Of Chemotaxis Cell-cell Junction Regulation Of Leukocyte Migration Purine Ribonucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Purine Nucleotide Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?