MPP1 and ABCC4

Number of citations of the paper that reports this interaction (PubMedID 29146910)
37

Data Source:
BioGRID (fluorescent resonance energy transfer)

		MPP1	ABCC4
Description		MAGUK p55 scaffold protein 1	ATP binding cassette subfamily C member 4 (PEL blood group)
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GO Annotations	Cellular Component	Cytoskeleton Plasma Membrane Cell-cell Junction Membrane Cortical Cytoskeleton Stereocilium Centriolar Satellite Cell Projection	Nucleolus Golgi Apparatus Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Platelet Dense Granule Membrane External Side Of Apical Plasma Membrane
	Molecular Function	GMP Kinase Activity Signaling Receptor Binding Protein Binding	Nucleotide Binding Guanine Nucleotide Transmembrane Transporter Activity Protein Binding ATP Binding ABC-type Xenobiotic Transporter Activity Prostaglandin Transmembrane Transporter Activity Urate Transmembrane Transporter Activity Purine Nucleotide Transmembrane Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity ABC-type Bile Acid Transporter Activity Efflux Transmembrane Transporter Activity 15-hydroxyprostaglandin Dehydrogenase (NAD+) Activity ATP Hydrolysis Activity Glutathione Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity ABC-type Transporter Activity
	Biological Process	Signal Transduction GMP Metabolic Process GDP Metabolic Process Regulation Of Neutrophil Chemotaxis	Platelet Degranulation Xenobiotic Metabolic Process Xenobiotic Transmembrane Transport Lipid Transport Bile Acid And Bile Salt Transport Prostaglandin Transport Urate Transport Prostaglandin Secretion Glutathione Transmembrane Transport Transmembrane Transport Cilium Assembly CAMP Transport Leukotriene Transport Monoatomic Anion Transmembrane Transport Export Across Plasma Membrane Transport Across Blood-brain Barrier Guanine Nucleotide Transmembrane Transport
Pathways		Sensory processing of sound by outer hair cells of the cochlea	Platelet degranulation ABC-family proteins mediated transport Azathioprine ADME Paracetamol ADME
Drugs			ATP
Diseases
GWAS		Hematology traits ( 23263863) Mean corpuscular volume ( 23263863) Red blood cell traits ( 23446634)	Acute post-radiotherapy pain in breast cancer ( 31196165) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Breast cancer ( 17903305) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Longevity ( 20834067) Parent of origin effect on language impairment (paternal) ( 24571439) Platelet count ( 22139419 27863252 29403010 32888494) Plateletcrit ( 27863252 32888494) Postherpetic neuralgia ( 33685280) Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer ( 23478653) Serum metabolite levels ( 33031748)
Interacting Genes		46 interacting genes: ABCC4 ACER1 ACER2 AGPAT3 AMOTL2 AP2M1 APH1A ATP5F1C ATRAID DERL2 DGAT2L6 DLG4 DNPEP ERBIN FXR2 GADD45A GPRASP3 GSK3B GYPC HNRNPD INCA1 KLHL12 MAP3K20 MEOX2 NR1H2 OGT OPTN PAQR8 PRIMPOL RPRM RPS6KA1 RPS6KA6 SGSM2 SLC35E1 SMN1 SRSF10 STK3 STUB1 SYNGR3 TK1 TMEM239 TRIM55 TRIM63 USP21 UXT ZNF639	6 interacting genes: ERBIN MPP1 NHERF1 NHERF2 PDZK1 SNTA1
Entrez ID		4354	10257
HPRD ID		02370	05583
Ensembl ID		ENSG00000130830	ENSG00000125257
Uniprot IDs		B4E325 Q00013	A8K2Q2 O15439
PDB IDs		2EJY 2EV8 3NEY	8BJF 8BWO 8BWP 8BWQ 8BWR 8I4A 8I4B 8I4C 8IZ7 8IZ8 8IZ9 8IZA 8J3W 8J3Z 8XOK 8XOL 8XOM
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction TOR Signaling Ribosomal Protein S6 Kinase Activity N-acylsphingosine Amidohydrolase Activity	Signaling Receptor Binding Protein-membrane Adaptor Activity Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding PDZ Domain Binding Protein Localization To Plasma Membrane Microvillus Membrane Protein Localization To Cell Periphery Stereocilium Protein Localization To Membrane Brush Border Membrane Phosphatase Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Apical Plasma Membrane Regulation Of Sodium Ion Transport Regulation Of Monoatomic Ion Transport Plasma Membrane Neuromuscular Junction Renal Phosphate Ion Absorption Localization Within Membrane Beta-catenin Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Basal Protein Localization ErbB-2 Class Receptor Binding Intracellular Protein Localization Scavenger Receptor Binding Syntrophin Complex Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Molecular Adaptor Activity Growth Factor Receptor Binding Carnitine Transmembrane Transport Carnitine Transport Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Negative Regulation Of Monocyte Chemotactic Protein-1 Production Microvillus Organization Establishment Of Golgi Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Hemidesmosome GMP Kinase Activity Intracellular Phosphate Ion Homeostasis
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