MN1 and NCOA3

Number of citations of the paper that reports this interaction (PubMedID 12569362)
0

Data Source:
BioGRID (pull down)

		MN1	NCOA3
Description		MN1 proto-oncogene, transcriptional regulator	nuclear receptor coactivator 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	Protein Binding	RNA Polymerase II Complex Binding Transcription Coregulator Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Nuclear Receptor Binding Nuclear Thyroid Hormone Receptor Binding Protein Dimerization Activity Protein-lysine-acetyltransferase Activity Disordered Domain Specific Binding
	Biological Process	Intramembranous Ossification Regulation Of DNA-templated Transcription Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Vitamin D Receptor Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition	Chromatin Remodeling Regulation Of DNA-templated Transcription Cellular Response To Hormone Stimulus Cell Dedifferentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Vitamin D Receptor Signaling Pathway Cellular Response To Estradiol Stimulus Nuclear Protein Quality Control By The Ubiquitin-proteasome System Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Division
Pathways			PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling Estrogen-dependent gene expression MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Age-related cataracts ( 25352737) Blood pressure (smoking interaction) ( 25189868) FEV1 ( 30804560) Lung function (FEV1) ( 26635082 28166213) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 26635082) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mild obesity-related type 2 diabetes ( 34737425) Mitral valve prolapse ( 26301497) Moderate or severe prolonged lymphopenia in dimethyl fumarate-treated relapsing-remitting multiple sclerosis ( 31749835) Peak expiratory flow ( 30804560) Platelet count ( 27863252 32888494) Platelet reactivity in response to clopidogrel treatment ( 32472697) Plateletcrit ( 27863252 32888494) Pulse pressure ( 30224653) Red blood cell count ( 32888494) Refractive error ( 32231278) Resting heart rate ( 27798624) Urate levels in obese individuals ( 25811787) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Osteoarthritis (hip) ( 23989986) Response to treatment for acute lymphoblastic leukemia ( 19176441)
Interacting Genes		3 interacting genes: CHEK2 EP300 NCOA3	81 interacting genes: ABL1 ANKRD11 AR ARNT2 ATAD2 BABAM2 BMP6 BMP7 BRCA1 CCND1 CDKN3 CHUK CREBBP CSNK1E DCTN6 DDX17 DDX5 E2F1 EP300 ESR1 ESR2 ESRRA ESRRB ETV1 FOS GSK3B GTF2B H3-4 H4C16 HNF1A IKBKB IKBKG IQCK JUN KAT2B MAPK1 MAPK14 MAPK8 MMS19 MN1 MRTFA MRTFB NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR1I2 NR1I3 NR2F1 NR3C1 NR4A1 NR5A2 PGR PIN1 PPARA PPARD PPARG PRKCZ PRMT1 PSMB9 PSME3 RARA RARB RARG RELA RXRA RXRB SLC22A2 SMARCE1 SUFU SUMO1 TBP THRB TP53 TP53BP1 VDR YWHAH YWHAQ
Entrez ID		4330	8202
HPRD ID		08862	03570
Ensembl ID		ENSG00000169184	ENSG00000124151
Uniprot IDs		Q10571	Q59EE8 Q9Y6Q9
PDB IDs			1KBH 3L3X 3L3Z 6ES7 6SQC
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone Acetyltransferase Activity Protein-lysine-acetyltransferase Activity Nuclear Receptor Binding Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Autophagosome Assembly Cellular Response To Oxygen-containing Compound Peptidyl-lysine Propionylation Swimming Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Autophagosome Organization Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Signal Transduction By P53 Class Mediator Transcription Coregulator Activity Regulation Of Signal Transduction By P53 Class Mediator Acyltransferase Activity Vacuole Organization Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Cellular Response To Radiation Intrinsic Apoptotic Signaling Pathway Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Negative Regulation Of DNA Damage Checkpoint Protein Stabilization Negative Regulation Of Protein Oligomerization Vitamin D Receptor Signaling Pathway Cellular Response To Bisphenol A Transcription Coactivator Activity Positive Regulation Of RNA Biosynthetic Process L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Transferase Activity Positive Regulation Of DNA-templated Transcription Apoptotic Signaling Pathway Cell Dedifferentiation Response To Bisphenol A Regulation Of Protein Stability Intracellular Signal Transduction	Nuclear Receptor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Intracellular Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of Metabolic Process Nuclear Receptor-mediated Signaling Pathway Intracellular Signal Transduction Nucleoplasm Regulation Of Gene Expression Chromatin Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Nucleus Regulation Of Metabolic Process Regulation Of MiRNA Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Steroid Receptor Activity RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Enzyme Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?