NCOA3 and ESRRB

Number of citations of the paper that reports this interaction (PubMedID 10598588)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		NCOA3	ESRRB
Description		nuclear receptor coactivator 3	estrogen related receptor beta
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Extracellular Exosome	Chromatin Condensed Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Integrator Complex
	Molecular Function	RNA Polymerase II Complex Binding Transcription Coregulator Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Nuclear Receptor Binding Nuclear Thyroid Hormone Receptor Binding Protein Dimerization Activity Protein-lysine-acetyltransferase Activity Disordered Domain Specific Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Estrogen Response Element Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromatin Remodeling Regulation Of DNA-templated Transcription Cellular Response To Hormone Stimulus Cell Dedifferentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Vitamin D Receptor Signaling Pathway Cellular Response To Estradiol Stimulus Nuclear Protein Quality Control By The Ubiquitin-proteasome System Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Division	Embryonic Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Stem Cell Division Stem Cell Population Maintenance Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Cell Dedifferentiation Photoreceptor Cell Maintenance Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Morula Formation Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Division Negative Regulation Of Stem Cell Differentiation
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling Estrogen-dependent gene expression MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Nuclear Receptor transcription pathway
Drugs			Diethylstilbestrol Genistein Flavone
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Osteoarthritis (hip) ( 23989986) Response to treatment for acute lymphoblastic leukemia ( 19176441)	Maximal oxygen uptake response ( 25729143) Sphingomyelin 24:0 levels ( 31560688) Tuberculosis ( 30287856)
Interacting Genes		81 interacting genes: ABL1 ANKRD11 AR ARNT2 ATAD2 BABAM2 BMP6 BMP7 BRCA1 CCND1 CDKN3 CHUK CREBBP CSNK1E DCTN6 DDX17 DDX5 E2F1 EP300 ESR1 ESR2 ESRRA ESRRB ETV1 FOS GSK3B GTF2B H3-4 H4C16 HNF1A IKBKB IKBKG IQCK JUN KAT2B MAPK1 MAPK14 MAPK8 MMS19 MN1 MRTFA MRTFB NCOR1 NCOR2 NKX2-1 NPAS2 NR0B2 NR1H2 NR1H3 NR1I2 NR1I3 NR2F1 NR3C1 NR4A1 NR5A2 PGR PIN1 PPARA PPARD PPARG PRKCZ PRMT1 PSMB9 PSME3 RARA RARB RARG RELA RXRA RXRB SLC22A2 SMARCE1 SUFU SUMO1 TBP THRB TP53 TP53BP1 VDR YWHAH YWHAQ	8 interacting genes: DLST HIF1A HSP90AA1 HSP90AB1 NCOA2 NCOA3 NRIP1 SP1
Entrez ID		8202	2103
HPRD ID		03570	03700
Ensembl ID		ENSG00000124151	ENSG00000119715
Uniprot IDs		Q59EE8 Q9Y6Q9	A0A2R8Y491 E7EWD9 O95718
PDB IDs		1KBH 3L3X 3L3Z 6ES7 6SQC	1LO1 6LIT 6LN4
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Intracellular Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of Metabolic Process Nuclear Receptor-mediated Signaling Pathway Intracellular Signal Transduction Nucleoplasm Regulation Of Gene Expression Chromatin Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Nucleus Regulation Of Metabolic Process Regulation Of MiRNA Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Steroid Receptor Activity RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Enzyme Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific	Histone Deacetylase Binding Nuclear Receptor Binding Disordered Domain Specific Binding Protein Dimerization Activity Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Metabolic Process Telomerase Holoenzyme Complex Assembly Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Nucleoplasm Protein-containing Complex Positive Regulation Of Biosynthetic Process Transcription Coregulator Activity Chromatin Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase DNA Polymerase Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Axonal Growth Cone RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Protein Folding Chaperone Complex Response To Hormone ATP-dependent Protein Folding Chaperone Cellular Response To Estradiol Stimulus Positive Regulation Of Developmental Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Post-translational Protein Modification Tau Protein Binding Rhythmic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Heat Transcription Coactivator Activity Ubiquitin Protein Ligase Binding Euchromatin Protein Folding Chaperone Nucleus Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Regulation Of Nitric Oxide Biosynthetic Process Response To Estrogen Cellular Response To Hormone Stimulus Dihydrolipoyllysine-residue Succinyltransferase Activity
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