MAP3K11 and NEIL1

		MAP3K11	NEIL1
Description		mitogen-activated protein kinase kinase kinase 11	nei like DNA glycosylase 1
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Membrane	Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity	Nucleic Acid Binding DNA Binding Damaged DNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Lyase Activity DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Microtubule-based Process JNK Cascade Positive Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Positive Regulation Of Neuron Apoptotic Process Cell Cycle G1/S Phase Transition Positive Regulation Of JNK Cascade Protein Autophosphorylation	DNA Repair Base-excision Repair Base-excision Repair, Gap-filling DNA Damage Response Response To Oxidative Stress Negative Regulation Of Nuclease Activity Depyrimidination
Pathways		RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF CDC42 GTPase cycle RHOG GTPase cycle RHOV GTPase cycle Signaling downstream of RAS mutants	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Defective Base Excision Repair Associated with NEIL1
Drugs		Fostamatinib	Iron Copper Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS		Acne (severe) ( 24927181 30542056) Coronary artery disease ( 29212778) Eosinophil count ( 27863252) Estimated glomerular filtration rate ( 31015462) Gout ( 25646370) Mean platelet volume ( 27863252) Refractive error ( 32231278) Serum uric acid levels ( 32514006) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes ( 28566273 30297969) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		35 interacting genes: AKT1 APP CDC42 CHUK CLEC4G COPS5 DSCAM EPS8 FKBP2 IKBKB KIF17 KIF3A KIF3B KIFAP3 LATS1 MAP2K4 MAP2K7 MAP3K12 MAP3K21 MAP4K1 MAP4K2 MAPK8IP1 MAPK8IP2 MAPK8IP3 MYO7A NEIL1 PIN1 PNLIPRP2 RAC1 RHOG SH3RF1 STUB1 TIA1 TRAF6 TSGA10IP	6 interacting genes: APP HUS1 MAP3K11 POLB RAD1 XRCC1
Entrez ID		4296	79661
HPRD ID		02502	12314
Ensembl ID		ENSG00000173327	ENSG00000140398
Uniprot IDs		Q16584	Q96FI4
PDB IDs		5K26 5K28 6AQB 6CQ7	1TDH 4NRV 5ITQ 5ITR 5ITT 5ITU 5ITX 5ITY 6LWA 6LWB 6LWC 6LWD 6LWF 6LWG 6LWH 6LWI 6LWJ 6LWK 6LWL 6LWM 6LWN 6LWO 6LWP 6LWQ 6LWR 7TMX 8FTJ
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette MAPK Cascade Intracellular Signal Transduction Regulation Of JNK Cascade Regulation Of MAPK Cascade JNK Cascade Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Postsynapse Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Positive Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Nucleotide Binding Kinesin II Complex MAP-kinase Scaffold Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Axo-dendritic Transport Protein Kinase Binding Protein Serine Kinase Activity Regulation Of Apoptotic Process Protein Kinase Activity Transport Along Microtubule Regulation Of Programmed Cell Death Signal Transduction Glutamatergic Synapse Cytoskeleton-dependent Intracellular Transport Fc-epsilon Receptor Signaling Pathway Plus-end-directed Vesicle Transport Along Microtubule Regulation Of Signal Transduction ATP Binding Microtubule-based Transport Kinase Activity Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Plus-end-directed Organelle Transport Along Microtubule Regulation Of Postsynapse Organization Cell Projection Organization CD40 Receptor Complex Anterograde Dendritic Transport JUN Kinase Binding Regulation Of Phosphorus Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphorylation Photoreceptor Connecting Cilium Kinesin Binding Kinesin Complex Establishment Of Vesicle Localization Cytoplasm	Checkpoint Clamp Complex Damaged DNA Binding Meiotic Cell Cycle Checkpoint Signaling Response To Radiation DNA Repair Response To Ionizing Radiation Intracellular Signal Transduction DNA Metabolic Process Double-strand Break Repair DNA Damage Response DNA Recombination Base-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Enzyme Binding Positive Regulation Of Neuron Apoptotic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Ionizing Radiation Oxidized DNA Binding Positive Regulation Of JNK Cascade Macromolecule Metabolic Process Telomere Maintenance DNA Damage Checkpoint Signaling Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Stress Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cellular Response To Stress Telomere Organization Meiotic DNA Integrity Checkpoint Signaling Immunoglobulin Heavy Chain V-D-J Recombination Meiotic Recombination Checkpoint Signaling ADP-D-ribose Modification-dependent Protein Binding Telomeric DNA-containing Double Minutes Formation Negative Regulation Of Protein ADP-ribosylation Negative Regulation Of Protection From Non-homologous End Joining At Telomere Regulation Of JNK Cascade Signal Transduction In Response To DNA Damage
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