MC1R and POMC

Number of citations of the paper that reports this interaction (PubMedID 9058374)
0

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		MC1R	POMC
Description		melanocortin 1 receptor	proopiomelanocortin
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Extracellular Region Extracellular Space Cytoplasm Peroxisome Peroxisomal Matrix Secretory Granule Secretory Granule Lumen
	Molecular Function	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Ubiquitin Protein Ligase Binding Hormone Binding	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Protein Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway UV Protection Regulation Of Gene Expression Sensory Perception Of Pain Negative Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Melanin Biosynthetic Process Pigmentation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Feeding Behavior UV-damage Excision Repair Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Feeding Behavior	Generation Of Precursor Metabolites And Energy Signal Transduction Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Calcium-mediated Signaling Killing Of Cells Of Another Organism Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Modulation Of Process Of Another Organism Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of Glycogen Metabolic Process Positive Regulation Of Neutrophil Mediated Killing Of Fungus Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Oxytocin Production Response To Melanocyte-stimulating Hormone Regulation Of Corticosterone Secretion
Pathways		Peptide ligand-binding receptors G alpha (s) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity	Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes obesity and POMCD Interleukin-4 and Interleukin-13 signaling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Afamelanotide CZEN 002 Bremelanotide	Loperamide Etorphine Dihydromorphine
Diseases
GWAS		Basal cell carcinoma ( 27539887 21700618 31174203) Black vs. non-black hair color ( 26184321) Black vs. red hair color ( 18483556) Blond vs. brown hair color ( 17952075) Blond vs. brown/black hair color ( 30531825) Brain morphology (MOSTest) ( 32665545) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Cutaneous squamous cell carcinoma ( 27424798) Facial pigmentation ( 25705849) Facial pigmentation measurement (polar light) ( 32835660) Facial pigmentation measurement (UV light) ( 32835660) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 20585627 29662168 23548203) Hair morphology traits ( 30166351) Hemoglobin levels ( 32327693) Keratinocyte cancer (MTAG) ( 31174203) Light vs. dark hair color ( 26184321) Low tan response ( 29739929) Melanoma ( 19578364 21983787 28212542 24980573) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 30429480 32341527) Non-melanoma skin cancer ( 29739929 23548203) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Perceived skin darkness ( 25963972) Red vs non-red hair color ( 26184321 17952075) Red vs. brown/black hair color ( 30531825) Skin aging (microtopography measurement) ( 28502801) Skin colour saturation ( 25963972) Skin pigmentation ( 30664655) Skin pigmentation traits ( 30166351) Skin sensitivity to sun ( 25963972 17952075) Squamous cell carcinoma ( 26829030) Sunburns ( 23548203) Tanning ( 23548203 19340012) Vitiligo ( 22561518 27723757) Youthful appearance (self-reported) ( 32339537)	Body mass index ( 20935630 23669352 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 28067908) Height ( 18391951 23563607 28552196) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Red vs. brown/black hair color ( 30531825) Type 1 diabetes ( 21980299)
Interacting Genes		4 interacting genes: ASIP ICAM1 MC4R POMC	28 interacting genes: ABI2 AIRIM APP ATP6V0D2 BHLHA9 CCDC102B ESRRG FGF10 GLYCTK HDDC2 HLA-DRB3 HSF2BP KLHL42 MC1R MC2R MC3R MC4R MC5R MEP1A MKRN3 NFKBID NRDC NTAQ1 OAZ3 PAM SUOX TXN2 VTN
Entrez ID		4157	5443
HPRD ID		01118	01462
Ensembl ID		ENSG00000258839	ENSG00000115138
Uniprot IDs		Q01726 Q1JUL4	P01189
PDB IDs		7F4D 7F4F 7F4H 7F4I	4XNH 4XPD 4Y49 6TUB 7F53 7F54 7PIV 8F7Q 8INR 8IOC
Enriched GO Terms of Interacting Partners?		Response To Melanocyte-stimulating Hormone Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Pigmentation Feeding Behavior Melanocortin Receptor Binding Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Oxytocin Production Positive Regulation Of Neutrophil Mediated Killing Of Fungus Carbohydrate Homeostasis T Cell Antigen Processing And Presentation Glucose Homeostasis Melanocyte-stimulating Hormone Receptor Activity Cellular Pigmentation Type 1 Melanocortin Receptor Binding Positive Regulation Of Killing Of Cells Of Another Organism Membrane To Membrane Docking T Cell Extravasation Melanocortin Receptor Activity Regulation Of Corticosterone Secretion Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Receptor-mediated Virion Attachment To Host Cell T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Response To Peptide Hormone Regulation Of Eating Behavior Generation Of Precursor Metabolites And Energy Positive Regulation Of Melanin Biosynthetic Process Adult Feeding Behavior Extracellular Space Virion Attachment To Host Cell Adhesion Of Symbiont To Host Cell Signaling Receptor Binding Melanin Metabolic Process Regulation Of Melanin Biosynthetic Process Epigenetic Programming In The Zygotic Pronuclei Melanin Biosynthetic Process Adhesion Of Symbiont To Host Positive Regulation Of Bone Resorption Positive Regulation Of Cellular Extravasation Cellular Extravasation Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Regulation Of Hormone Levels Regulation Of Appetite Pigment Granule Localization Neuropeptide Binding	Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Feeding Behavior Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Hormone Binding G Protein-coupled Receptor Activity Regulation Of Behavior Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Chemoattractant Activity Amylin Binding Positive Regulation Of Toll Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Protein Binding Protein Serine/threonine Kinase Binding Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Urothelial Cell Proliferation Lung Proximal/distal Axis Specification Bronchiole Morphogenesis Urothelial Cell Proliferation Embryonic Genitalia Morphogenesis Semicircular Canal Fusion Mesenchymal-epithelial Cell Signaling Involved In Lung Development Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Submandibular Salivary Gland Formation Corticotropin Receptor Activity Neuropeptide Binding Peptidylamidoglycolate Lyase Activity Peptidylglycine Monooxygenase Activity Fatty Acid Primary Amide Biosynthetic Process Sulfite Oxidase Activity Symbiont-containing Vacuole Protein-N-terminal Glutamine Amidohydrolase Activity Glycerate Kinase Activity
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