MC1R and MC4R

Number of citations of the paper that reports this interaction (PubMedID 12165561)
0

Data Source:
HPRD (in vitro, in vivo)

		MC1R	MC4R
Description		melanocortin 1 receptor	melanocortin 4 receptor
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Cytoplasm Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Ubiquitin Protein Ligase Binding Hormone Binding	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding Ubiquitin Protein Ligase Binding Neuropeptide Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway UV Protection Regulation Of Gene Expression Sensory Perception Of Pain Negative Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Melanin Biosynthetic Process Pigmentation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Feeding Behavior UV-damage Excision Repair Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Feeding Behavior	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Feeding Behavior Regulation Of Metabolic Process Insulin Secretion Response To Food Response To Insulin Positive Regulation Of Bone Resorption Regulation Of Feeding Behavior Regulation Of Eating Behavior Response To Melanocyte-stimulating Hormone
Pathways		Peptide ligand-binding receptors G alpha (s) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity	Peptide ligand-binding receptors G alpha (s) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Afamelanotide CZEN 002 Bremelanotide	Bremelanotide Setmelanotide
Diseases
GWAS		Basal cell carcinoma ( 27539887 21700618 31174203) Black vs. non-black hair color ( 26184321) Black vs. red hair color ( 18483556) Blond vs. brown hair color ( 17952075) Blond vs. brown/black hair color ( 30531825) Brain morphology (MOSTest) ( 32665545) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Cutaneous squamous cell carcinoma ( 27424798) Facial pigmentation ( 25705849) Facial pigmentation measurement (polar light) ( 32835660) Facial pigmentation measurement (UV light) ( 32835660) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 20585627 29662168 23548203) Hair morphology traits ( 30166351) Hemoglobin levels ( 32327693) Keratinocyte cancer (MTAG) ( 31174203) Light vs. dark hair color ( 26184321) Low tan response ( 29739929) Melanoma ( 19578364 21983787 28212542 24980573) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 30429480 32341527) Non-melanoma skin cancer ( 29739929 23548203) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Perceived skin darkness ( 25963972) Red vs non-red hair color ( 26184321 17952075) Red vs. brown/black hair color ( 30531825) Skin aging (microtopography measurement) ( 28502801) Skin colour saturation ( 25963972) Skin pigmentation ( 30664655) Skin pigmentation traits ( 30166351) Skin sensitivity to sun ( 25963972 17952075) Squamous cell carcinoma ( 26829030) Sunburns ( 23548203) Tanning ( 23548203 19340012) Vitiligo ( 22561518 27723757) Youthful appearance (self-reported) ( 32339537)	Adult body size ( 32376654) Antipsychotic drug-induced weight gain ( 22566560) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body fat percentage ( 26833246) Body mass index ( 18454148 19079260 19079261 20935630 23563607 23669352 24064335 24348519 24861553 25673413 25953783 26426971 26961502 28448500 28552196 28892062 29273807 29381148 31453325) Body mass index (adult) ( 28430825) Body mass index (age <50) ( 26426971) Body mass index (age interaction) ( 25953783) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) C-reactive protein levels ( 30388399) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Childhood body mass index ( 26604143 33045005) Childhood onset type 2 diabetes ( 33479058) Cobalt levels ( 26025379) Coffee consumption ( 31046077) Coffee consumption (cups per day) ( 31837886) Coronary artery disease ( 26343387 33020668) Daytime sleep phenotypes ( 27126917) Dentures ( 31235808) Diastolic blood pressure ( 27841878) Fat body mass ( 24064335) Fatty acid desaturase activity (serum) ( 30453627) Femoral neck bone mineral density ( 30172743) Free thyroxine concentration ( 30367059) Fruit consumption ( 32066663) Hand grip strength ( 29691431) HDL cholesterol ( 20686565 24097068) HDL cholesterol levels ( 28334899 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Height ( 20881960 25282103 25429064 31562340) Hip circumference ( 25673412 28552196 31453325) Hip circumference variance ( 31453325) Leg fat mass and leg lean mass (pleiotropy) ( 32719433) Leg lean mass (fat adjusted) ( 32719433) Metabolic syndrome ( 31589552) Myocardial infarction ( 33532862) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obese vs. thin ( 30677029) Obesity ( 19151714 23563607) Obesity (early onset extreme) ( 20421936 23563609) Obesity (extreme) ( 30677029) Obesity-related traits ( 22013104) Systolic blood pressure ( 30224653) Total body bone mineral density ( 30172743) Triglyceride levels ( 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes ( 22885922 24509480 28869590 30054458 30297969 30718926 32499647) Ulna and radius bone mineral density ( 30172743) Urate levels ( 23263486 31578528) Waist circumference ( 19557197 25673412 28552196 31453325) Waist circumference and related phenotypes ( 18454146) Waist circumference variance ( 31453325) Waist-hip ratio ( 25673412) Weight ( 19079260)
Interacting Genes		4 interacting genes: ASIP ICAM1 MC4R POMC	20 interacting genes: AGRP AIG1 ASIP ATP6V0E2 ATRNL1 CD81 GRK2 IL1RAP MAL MC1R NPC1 NPY PDIA6 PLLP POMC PRKACA TMEM19 TMEM94 TSPAN3 YIPF3
Entrez ID		4157	4160
HPRD ID		01118	01116
Ensembl ID		ENSG00000258839	ENSG00000166603
Uniprot IDs		Q01726 Q1JUL4	P32245
PDB IDs		7F4D 7F4F 7F4H 7F4I	6W25 7AUE 7F53 7F54 7F55 7F58 7PIU 7PIV 8QJ2 8WKY 8WKZ
Enriched GO Terms of Interacting Partners?		Response To Melanocyte-stimulating Hormone Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Pigmentation Feeding Behavior Melanocortin Receptor Binding Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Oxytocin Production Positive Regulation Of Neutrophil Mediated Killing Of Fungus Carbohydrate Homeostasis T Cell Antigen Processing And Presentation Glucose Homeostasis Melanocyte-stimulating Hormone Receptor Activity Cellular Pigmentation Type 1 Melanocortin Receptor Binding Positive Regulation Of Killing Of Cells Of Another Organism Membrane To Membrane Docking T Cell Extravasation Melanocortin Receptor Activity Regulation Of Corticosterone Secretion Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Receptor-mediated Virion Attachment To Host Cell T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Response To Peptide Hormone Regulation Of Eating Behavior Generation Of Precursor Metabolites And Energy Positive Regulation Of Melanin Biosynthetic Process Adult Feeding Behavior Extracellular Space Virion Attachment To Host Cell Adhesion Of Symbiont To Host Cell Signaling Receptor Binding Melanin Metabolic Process Regulation Of Melanin Biosynthetic Process Epigenetic Programming In The Zygotic Pronuclei Melanin Biosynthetic Process Adhesion Of Symbiont To Host Positive Regulation Of Bone Resorption Positive Regulation Of Cellular Extravasation Cellular Extravasation Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Regulation Of Hormone Levels Regulation Of Appetite Pigment Granule Localization Neuropeptide Binding	Adult Feeding Behavior Positive Regulation Of Feeding Behavior Neuropeptide Hormone Activity Positive Regulation Of Behavior Regulation Of Feeding Behavior Type 1 Melanocortin Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding G Protein-coupled Receptor Signaling Pathway Pigmentation Adult Behavior Structural Constituent Of Myelin Sheath G Protein-coupled Receptor Binding Regulation Of Behavior Melanin Biosynthetic Process Melanin Metabolic Process Feeding Behavior Neuropeptide Signaling Pathway Symbiont Entry Into Host Cell Membrane Chemical Homeostasis Regulation Of Appetite Photoperiodism Membrane Raft Organization Cellular Response To Low-density Lipoprotein Particle Stimulus Negative Regulation Of Relaxation Of Smooth Muscle Biological Process Involved In Interaction With Host Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Signaling Receptor Binding Long-day Photoperiodism Secondary Metabolic Process Melanocortin Receptor Binding Cell Communication Cellular Response To Lipoprotein Particle Stimulus Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Protein Insertion Into Plasma Membrane Plasma Membrane Raft Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Intracellular Monoatomic Ion Homeostasis Short-day Photoperiodism Intracellular Monoatomic Cation Homeostasis Cyclodextrin Metabolic Process Positive Regulation Of Oxytocin Production P-type Magnesium Transporter Activity Magnesium Ion Transport From Cytosol To Endoplasmic Reticulum Regulation Of Macroautophagy Plasma Membrane Cholesterol Binding
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