MBP and BMP2K

Number of citations of the paper that reports this interaction (PubMedID 11500515)
0

Data Source:
HPRD (in vitro)

		MBP	BMP2K
Description		myelin basic protein	BMP2 inducible kinase
Image
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Cell Surface Membrane Protein-containing Complex Internode Region Of Axon Cell Projection Neuronal Cell Body Myelin Sheath Compact Myelin Synapse Cell Periphery	Nucleus Cytoplasm Nuclear Speck
	Molecular Function	Protease Binding Protein Binding Calmodulin Binding Lipid Binding Structural Constituent Of Myelin Sheath	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Phosphatase Regulator Activity AP-2 Adaptor Complex Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Immune Response Chemical Synaptic Transmission Central Nervous System Development Sensory Perception Of Sound Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Positive Regulation Of Interleukin-6 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Maintenance Of Blood-brain Barrier Myelination Membrane Organization Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Regulation Of Bone Mineralization Positive Regulation Of Notch Signaling Pathway Regulation Of Clathrin-dependent Endocytosis
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs			Fostamatinib
Diseases
GWAS		Age-related macular degeneration (geographic atrophy) ( 22705344) Blood osmolality (transformed sodium) ( 28360221) Depression in smokers ( 30219690) Erythrocyte cadmium concentration in never smokers ( 27005419) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Verbal declarative memory ( 25648963)	Albumin-globulin ratio ( 29403010) Aspartate aminotransferase levels ( 29403010) Common carotid intima-media thickness in HIV infection ( 29206233) Daytime nap ( 33568662) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494 29403010) Mean spheric corpuscular volume ( 32888494) Non-albumin protein levels ( 29403010) Platelet distribution width ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum albumin levels ( 29403010) Serum total protein levels ( 29403010)
Interacting Genes		83 interacting genes: ABL1 ADRB2 APTX ATN1 ATXN1 AURKA BMP2K CCR1 CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 CTDSPL DYRK1B HIPK2 HLA-DRA IKBKE ILK IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP2K1 MAP3K1 MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPK8 MAPKAPK5 MELK MICU2 MKNK1 MMP7 NEIL3 NEK9 PAK1 PDGFRL PKN1 PLEKHF2 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 PTAFR PTPRA RAF1 RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSC1 TSSK6 ULK1	1 interacting genes: MBP
Entrez ID		4155	55589
HPRD ID		01158	09828
Ensembl ID		ENSG00000197971	ENSG00000138756
Uniprot IDs		P02686	Q9NSY1
PDB IDs		1BX2 1FV1 1HQR 1K2D 1YMM 1ZGL	4W9W 4W9X 5I3O 5I3R 5IKW
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Kinase Activity Kinase Activity Protein Phosphorylation ATP Binding Phosphorylation Transferase Activity Nucleotide Binding Intracellular Signal Transduction Protein Modification Process Phosphate-containing Compound Metabolic Process MAPK Cascade Protein Metabolic Process Response To Stress Intracellular Signaling Cassette Cellular Response To Stress Peptidyl-serine Phosphorylation Macromolecule Metabolic Process Protein Autophosphorylation Signal Transduction MAP Kinase Activity Regulation Of Cell Differentiation Regulation Of Intracellular Signal Transduction Positive Regulation Of Biosynthetic Process Regulation Of Developmental Process Regulation Of MAPK Cascade Nucleus Positive Regulation Of Developmental Process Magnesium Ion Binding Positive Regulation Of Intracellular Signal Transduction DNA Damage Response RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Development Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Peptidyl-threonine Phosphorylation Nucleoplasm Stress-activated MAPK Cascade Regulation Of Gene Expression Stress-activated Protein Kinase Signaling Cascade Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Cell Surface Receptor Signaling Pathway	Positive Regulation Of Metalloendopeptidase Activity Regulation Of Metallopeptidase Activity Internode Region Of Axon Compact Myelin Negative Regulation Of Heterotypic Cell-cell Adhesion Structural Constituent Of Myelin Sheath Positive Regulation Of Peptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Endopeptidase Activity Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Myelin Sheath Maintenance Of Blood-brain Barrier Substantia Nigra Development Neural Nucleus Development Positive Regulation Of Chemokine Production Cell Periphery Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Myelination Response To Toxic Substance Axon Ensheathment Protease Binding Positive Regulation Of Hydrolase Activity Sensory Perception Of Mechanical Stimulus Sensory Perception Of Sound Central Nervous System Development Regulation Of Interleukin-6 Production Anatomical Structure Homeostasis Tissue Homeostasis Calmodulin Binding Positive Regulation Of Proteolysis Negative Regulation Of Cell-cell Adhesion MAPK Cascade Positive Regulation Of Catalytic Activity Negative Regulation Of Cell Adhesion Chemical Synaptic Transmission Lipid Binding Trans-synaptic Signaling Synaptic Signaling Neuronal Cell Body
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