MBP and STK26

Number of citations of the paper that reports this interaction (PubMedID 11641781)
0

Data Source:
HPRD (in vitro, in vivo)

		MBP	STK26
Description		myelin basic protein	serine/threonine kinase 26
Image
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Cell Surface Membrane Protein-containing Complex Internode Region Of Axon Cell Projection Neuronal Cell Body Myelin Sheath Compact Myelin Synapse Cell Periphery	Cytoplasm Golgi Apparatus Golgi-associated Vesicle Cytosol Vesicle Membrane Membrane Apical Plasma Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery FAR/SIN/STRIPAK Complex
	Molecular Function	Protease Binding Protein Binding Calmodulin Binding Lipid Binding Structural Constituent Of Myelin Sheath	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Immune Response Chemical Synaptic Transmission Central Nervous System Development Sensory Perception Of Sound Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Positive Regulation Of Interleukin-6 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Maintenance Of Blood-brain Barrier Myelination Membrane Organization Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Protein Phosphorylation Apoptotic Process Cellular Response To Starvation Negative Regulation Of Cell Migration Cellular Response To Oxidative Stress Intracellular Signal Transduction Regulation Of Apoptotic Process Protein Autophosphorylation Positive Regulation Of Microvillus Assembly
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination	Apoptotic cleavage of cellular proteins
Drugs			2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrile Fostamatinib
Diseases
GWAS		Age-related macular degeneration (geographic atrophy) ( 22705344) Blood osmolality (transformed sodium) ( 28360221) Depression in smokers ( 30219690) Erythrocyte cadmium concentration in never smokers ( 27005419) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Verbal declarative memory ( 25648963)	Gestational age at birth (maternal effect) ( 28877031)
Interacting Genes		83 interacting genes: ABL1 ADRB2 APTX ATN1 ATXN1 AURKA BMP2K CCR1 CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 CTDSPL DYRK1B HIPK2 HLA-DRA IKBKE ILK IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP2K1 MAP3K1 MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPK8 MAPKAPK5 MELK MICU2 MKNK1 MMP7 NEIL3 NEK9 PAK1 PDGFRL PKN1 PLEKHF2 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 PTAFR PTPRA RAF1 RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSC1 TSSK6 ULK1	13 interacting genes: APP CEP76 CFTR GOLGA2 GRB14 IKZF3 MBP NEDD4 OGT RAF1 SRPK1 TRAF6 TRIM27
Entrez ID		4155	51765
HPRD ID		01158	06663
Ensembl ID		ENSG00000197971	ENSG00000134602
Uniprot IDs		P02686	Q9P289
PDB IDs		1BX2 1FV1 1HQR 1K2D 1YMM 1ZGL	3GGF 3W8I 4FZA 4FZD 4FZF 4GEH 5XY9 5YF4 7B36
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Kinase Activity Kinase Activity Protein Phosphorylation ATP Binding Phosphorylation Transferase Activity Nucleotide Binding Intracellular Signal Transduction Protein Modification Process Phosphate-containing Compound Metabolic Process MAPK Cascade Protein Metabolic Process Response To Stress Intracellular Signaling Cassette Cellular Response To Stress Peptidyl-serine Phosphorylation Macromolecule Metabolic Process Protein Autophosphorylation Signal Transduction MAP Kinase Activity Regulation Of Cell Differentiation Regulation Of Intracellular Signal Transduction Positive Regulation Of Biosynthetic Process Regulation Of Developmental Process Regulation Of MAPK Cascade Nucleus Positive Regulation Of Developmental Process Magnesium Ion Binding Positive Regulation Of Intracellular Signal Transduction DNA Damage Response RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Development Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Peptidyl-threonine Phosphorylation Nucleoplasm Stress-activated MAPK Cascade Regulation Of Gene Expression Stress-activated Protein Kinase Signaling Cascade Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Cell Surface Receptor Signaling Pathway	Positive Regulation Of Protein Metabolic Process Protein-containing Complex Enzyme Binding Cytosol Protein K63-linked Ubiquitination Positive Regulation Of Macromolecule Metabolic Process Innate Immune Response Positive Regulation Of Interleukin-6 Production Regulation Of Protein Metabolic Process Response To Other Organism Protein Modification Process Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Immune Response Positive Regulation Of Metabolic Process Intracellular Signal Transduction Homeostatic Process Defense Response To Symbiont Defense Response To Other Organism Regulation Of Interleukin-6 Production Positive Regulation Of Biosynthetic Process Response To External Biotic Stimulus Cytoplasm Immune System Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Defense Response Negative Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Amyloid-beta Complex Regulation Of Phosphorus Metabolic Process Growth Cone Lamellipodium Regulation Of Primary Metabolic Process Protein Metabolic Process Positive Regulation Of Cytokine Production Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Negative Regulation Of Transcription By RNA Polymerase II Response To Stress Amylin Binding Negative Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Developmental Process Intracellular Chemical Homeostasis Leukocyte Activation Negative Regulation Of Cell Communication Establishment Of Localization In Cell Regulation Of Cellular Localization Intracellularly ATP-gated Chloride Channel Activity
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