MARK3 and ASB13

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		MARK3	ASB13
Description		microtubule affinity regulating kinase 3	ankyrin repeat and SOCS box containing 13
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Cell Projection Extracellular Exosome	Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Protein Phosphorylation Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Protein Localization To Nucleus	Protein Ubiquitination Intracellular Signal Transduction
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Transcriptional and post-translational regulation of MITF-M expression and activity	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Fostamatinib
Diseases
GWAS		Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778 33020668) Cutaneous melanoma or hair colour ( 32341527) Femoral neck bone mineral density ( 22504420) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Optic disc size ( 31809533) PR interval ( 32439900) Systolic blood pressure ( 30578418 30224653) Type 2 diabetes ( 30297969) White blood cell count ( 32888494)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Fasting insulin ( 34074324) Leukocyte telomere length ( 32109421) Pulse pressure ( 30578418)
Interacting Genes		33 interacting genes: ANKRD7 ARHGEF2 ASB13 ATP6V0C CDC25C CDC42BPB CHGB CLASP1 CPSF4 DYNLL1 FANCF FBXO7 HDAC7 HMOX2 KSR1 MAP2 MAPT MITF NOL11 PKP2 PMPCB PNPLA2 PRKCQ RCOR3 RECQL SAAL1 SFN SLC27A4 TCEA2 TTR VPS11 YWHAG YWHAZ	17 interacting genes: ASB9 DNM1 DUSP23 HAPLN2 HIF1AN KRTAP11-1 KRTAP15-1 MARK3 MSRB3 NUDT3 OXER1 POU6F2 TRIP13 UBAP2 VAC14 ZMIZ2 ZNF581
Entrez ID		4140	79754
HPRD ID		04058	10667
Ensembl ID		ENSG00000075413	ENSG00000196372
Uniprot IDs		A0A7I2V2E3 A0A7I2V2N8 A0A7I2V3B9 A0A7I2V5G3 A0A7I2V639 A0A7I2YQF7 H0YNV4 P27448 Q86U11	Q8WXK3
PDB IDs		2QNJ 3FE3 7P1L 8UOH 8UOI 8UOJ 8UOK 8UOL
Enriched GO Terms of Interacting Partners?		Protein Kinase C Inhibitor Activity Phosphoserine Residue Binding Main Axon Regulation Of Microtubule Polymerization Or Depolymerization Protein Sequestering Activity Negative Regulation Of Microtubule Polymerization Or Depolymerization Protein Kinase C Binding Regulation Of Phosphorylation Positive Regulation Of Intracellular Transport Dystroglycan Binding Protein Kinase Binding Tubulin Binding Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule Polymerization Phototransduction, Visible Light Regulation Of Cell Differentiation Microtubule	Vesicle Scission Clathrin Coat Assembly Involved In Endocytosis Meiotic Recombination Checkpoint Signaling 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Diphosphoinositol Polyphosphate Metabolic Process Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Diphosphoinositol Polyphosphate Catabolic Process Bis(5'-adenosyl)-hexaphosphatase Activity Diadenosine Hexaphosphate Catabolic Process Inositol Phosphate Catabolic Process Diadenosine Pentaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process Diphosphoinositol-polyphosphate Diphosphatase Activity Endopolyphosphatase Activity Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity [protein]-asparagine 3-dioxygenase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity Peptidyl-histidine Dioxygenase Activity PAS Complex Establishment Of Blood-nerve Barrier 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding Peptide-methionine (R)-S-oxide Reductase Activity L-methionine-(R)-S-oxide Reductase Activity
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