MARK3 and PNPLA2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MARK3	PNPLA2
Description		microtubule affinity regulating kinase 3	patatin like domain 2, triacylglycerol lipase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Cell Projection Extracellular Exosome	Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Lipoprotein Lipase Activity Phospholipase A2 Activity Triacylglycerol Lipase Activity Protein Binding Acylglycerol O-acyltransferase Activity Hydrolase Activity Retinyl-palmitate Esterase Activity Mono-olein Transacylation Activity Diolein Transacylation Activity
	Biological Process	Microtubule Cytoskeleton Organization Protein Phosphorylation Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Protein Localization To Nucleus	Retinoid Metabolic Process Lipid Metabolic Process Acylglycerol Metabolic Process Diacylglycerol Biosynthetic Process Phototransduction, Visible Light Negative Regulation Of Triglyceride Storage Positive Regulation Of Triglyceride Catabolic Process Lipid Catabolic Process Triglyceride Catabolic Process Lipid Storage Lipid Droplet Organization Intracellular Triglyceride Homeostasis Acylglycerol Acyl-chain Remodeling Retinol Metabolic Process Lipid Homeostasis Lipid Droplet Fusion Lipid Droplet Disassembly
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Transcriptional and post-translational regulation of MITF-M expression and activity	Acyl chain remodeling of DAG and TAG Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs		Fostamatinib
Diseases
GWAS		Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778 33020668) Cutaneous melanoma or hair colour ( 32341527) Femoral neck bone mineral density ( 22504420) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Optic disc size ( 31809533) PR interval ( 32439900) Systolic blood pressure ( 30578418 30224653) Type 2 diabetes ( 30297969) White blood cell count ( 32888494)	A body shape index ( 34021172) Body fat distribution (arm fat ratio) ( 30664634) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Keratoconus ( 31855235) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		33 interacting genes: ANKRD7 ARHGEF2 ASB13 ATP6V0C CDC25C CDC42BPB CHGB CLASP1 CPSF4 DYNLL1 FANCF FBXO7 HDAC7 HMOX2 KSR1 MAP2 MAPT MITF NOL11 PKP2 PMPCB PNPLA2 PRKCQ RCOR3 RECQL SAAL1 SFN SLC27A4 TCEA2 TTR VPS11 YWHAG YWHAZ	10 interacting genes: ABHD5 ARFGEF2 CYTH2 FAF2 GBF1 MARK3 PHYHIP SERPINF1 SMAD9 UBE2R2
Entrez ID		4140	57104
HPRD ID		04058	11443
Ensembl ID		ENSG00000075413	ENSG00000177666
Uniprot IDs		A0A7I2V2E3 A0A7I2V2N8 A0A7I2V3B9 A0A7I2V5G3 A0A7I2V639 A0A7I2YQF7 H0YNV4 P27448 Q86U11	Q96AD5
PDB IDs		2QNJ 3FE3 7P1L 8UOH 8UOI 8UOJ 8UOK 8UOL
Enriched GO Terms of Interacting Partners?		Protein Kinase C Inhibitor Activity Phosphoserine Residue Binding Main Axon Regulation Of Microtubule Polymerization Or Depolymerization Protein Sequestering Activity Negative Regulation Of Microtubule Polymerization Or Depolymerization Protein Kinase C Binding Regulation Of Phosphorylation Positive Regulation Of Intracellular Transport Dystroglycan Binding Protein Kinase Binding Tubulin Binding Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule Polymerization Phototransduction, Visible Light Regulation Of Cell Differentiation Microtubule	Regulation Of ARF Protein Signal Transduction Endomembrane System Organization Lipid Droplet Guanyl-nucleotide Exchange Factor Activity Protein Localization To Endoplasmic Reticulum Tubular Network Regulation Of Small GTPase Mediated Signal Transduction
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