LTC4S and BACE2

		LTC4S	BACE2
Description		leukotriene C4 synthase	beta-secretase 2
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane Intracellular Membrane-bounded Organelle	Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Melanosome Membrane Melanosome
	Molecular Function	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Lipid Binding Transferase Activity Lyase Activity Identical Protein Binding	Aspartic-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Lipid Metabolic Process Leukotriene Metabolic Process Leukotriene Biosynthetic Process Long-chain Fatty Acid Biosynthetic Process Carboxylic Acid Biosynthetic Process Cellular Oxidant Detoxification	Proteolysis Membrane Protein Ectodomain Proteolysis Protein Processing Peptide Hormone Processing Melanosome Organization Glucose Homeostasis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Amyloid-beta Metabolic Process
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Biosynthesis of Lipoxins (LX) Biosynthesis of maresin conjugates in tissue regeneration (MCTR) Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)
Drugs		Glutathione Azelastine
Diseases
GWAS			Adult body size ( 32376654) Body mass index ( 25673413) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Elevated fasting plasma glucose ( 30004843) Glycemic traits (pregnancy) ( 23903356) Systemic lupus erythematosus ( 32771030)
Interacting Genes		13 interacting genes: ALOX5 ALOX5AP BACE2 CD79A CREB3L1 EBP FFAR3 FXYD3 GPR152 GPR42 MGST1 SLC7A14 TMEM52B	13 interacting genes: ABCA8 ACVR2A APP DIP2A GGA1 GGA2 ICOSLG LTC4S PCM1 POFUT2 RAB27A SNRNP70 UBASH3A
Entrez ID		4056	25825
HPRD ID		02004	05744
Ensembl ID		ENSG00000213316	ENSG00000182240
Uniprot IDs		Q16873	Q9Y5Z0
PDB IDs		2PNO 2UUH 2UUI 3B29 3HKK 3LEO 3PCV 4BPM 4J7T 4J7Y 4JC7 4JCZ 4JRZ 4WAB 5HV9 6R7D 9G0U 9G0V 9G14 9G1T	2EWY 3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ 3ZKS 3ZKX 3ZL7 3ZLQ 4BEL 4BFB 6JSZ 6UJ0 6UJ1 7D5B 7D5U 7F1G 7N4N
Enriched GO Terms of Interacting Partners?		Leukotriene Production Involved In Inflammatory Response Arachidonate Metabolite Production Involved In Inflammatory Response Membrane Production Of Molecular Mediator Involved In Inflammatory Response Leukotriene Biosynthetic Process Glutathione Peroxidase Activity Negative Regulation Of Sprouting Angiogenesis Glutathione Transferase Activity Leukotriene Metabolic Process Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Nuclear Envelope Negative Regulation Of Response To Endoplasmic Reticulum Stress Icosanoid Biosynthetic Process Endoplasmic Reticulum Membrane Cellular Response To Lipid Hydroperoxide Cholesterol-5,6-oxide Hydrolase Activity Regulation Of Sprouting Angiogenesis Nuclear Membrane Leukotriene A4 Metabolic Process Arachidonate 8(S)-lipoxygenase Activity Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus C-8 Sterol Isomerase Activity Cholestenol Delta-isomerase Activity Cellular Oxidant Detoxification Regulation Of Response To Endoplasmic Reticulum Stress Lipoxin Biosynthetic Process Arachidonate 12(S)-lipoxygenase Activity Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell IgM B Cell Receptor Complex Response To Lipid Hydroperoxide Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol Steroid Delta-isomerase Activity Extracellular Matrix Constituent Secretion Icosanoid Metabolic Process G Protein-coupled Receptor Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Cellular Detoxification B Cell Receptor Complex Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Epoxide Metabolic Process Endoplasmic Reticulum Leukotriene-C4 Synthase Activity Small Molecule Biosynthetic Process Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Arachidonate Binding Gamma-aminobutyric Acid Import Gamma-aminobutyric Acid Transmembrane Transporter Activity	Regulation Of Protein Folding
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