BACE2

Description		beta-secretase 2
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GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Melanosome Membrane Melanosome
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Proteolysis Membrane Protein Ectodomain Proteolysis Protein Processing Peptide Hormone Processing Melanosome Organization Glucose Homeostasis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Amyloid-beta Metabolic Process
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 25673413) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Elevated fasting plasma glucose ( 30004843) Glycemic traits (pregnancy) ( 23903356) Systemic lupus erythematosus ( 32771030)
Novel Interacting Genes		13 novel interacting genes: ABCA8 ACVR2A APP DIP2A GGA1 GGA2 ICOSLG LTC4S PCM1 POFUT2 RAB27A SNRNP70 UBASH3A
Interacting Genes		13 interacting genes: ABCA8 ACVR2A APP DIP2A GGA1 GGA2 ICOSLG LTC4S PCM1 POFUT2 RAB27A SNRNP70 UBASH3A
Entrez ID		25825
HPRD ID		05744
Ensembl ID		ENSG00000182240
Uniprot IDs		Q9Y5Z0
PDB IDs		2EWY 3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ 3ZKS 3ZKX 3ZL7 3ZLQ 4BEL 4BFB 6JSZ 6UJ0 6UJ1 7D5B 7D5U 7F1G 7N4N
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Folding
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