LRP6 and WNT1

Number of citations of the paper that reports this interaction (PubMedID 11448771)
0

Data Source:
HPRD (in vivo)

		LRP6	WNT1
Description		LDL receptor related protein 6	Wnt family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Caveola Cell Surface Membrane Cytoplasmic Vesicle Early Endosome Membrane Neuronal Cell Body Membrane Raft Synapse Wnt-Frizzled-LRP5/6 Complex Wnt Signalosome	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Extracellular Exosome
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Signaling Receptor Binding Frizzled Binding Protein Binding Coreceptor Activity Wnt-protein Binding Kinase Inhibitor Activity Toxin Transmembrane Transporter Activity Protein Serine/threonine Kinase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Wnt Receptor Activity	Signaling Receptor Binding Frizzled Binding Cytokine Activity Morphogen Activity Protein Domain Specific Binding Receptor Ligand Activity
	Biological Process	Regulation Of DNA-templated Transcription Endocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Nervous System Development Tissue Development Neural Crest Formation Neural Crest Cell Differentiation Wnt Signaling Pathway Vesicle-mediated Transport Midbrain Development Negative Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Apoptotic Process Chordate Embryonic Development Response To Peptide Hormone Positive Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Transmembrane Transport Canonical Wnt Signaling Pathway Cellular Response To Cholesterol Dopaminergic Neuron Differentiation Protein Localization To Plasma Membrane Cell-cell Adhesion Midbrain Dopaminergic Neuron Differentiation	Embryonic Axis Specification Branching Involved In Ureteric Bud Morphogenesis Cell-cell Signaling Myoblast Fusion Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Wounding Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Cell-substrate Adhesion Myotube Differentiation Wnt Signaling Pathway Spinal Cord Association Neuron Differentiation Diencephalon Development Cerebellum Development Central Nervous System Morphogenesis Cerebellum Formation Forebrain Anterior/posterior Pattern Specification Midbrain-hindbrain Boundary Maturation During Brain Development Neurogenesis Metencephalon Development Negative Regulation Of Cell-cell Adhesion Neuron Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Midbrain Development Midbrain-hindbrain Boundary Development Animal Organ Regeneration T Cell Differentiation In Thymus Cell Proliferation In Midbrain Astrocyte-dopaminergic Neuron Signaling Inner Ear Morphogenesis Signal Transduction In Response To DNA Damage Negative Regulation Of Apoptotic Process Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Neuron Fate Commitment Neuron Fate Determination Spemann Organizer Formation Canonical Wnt Signaling Pathway Bone Development Positive Regulation Of Dermatome Development Hepatocyte Differentiation Cellular Response To Peptide Hormone Stimulus Hematopoietic Stem Cell Proliferation Dopaminergic Neuron Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Embryonic Brain Development Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Senescence
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination Signaling by RNF43 mutants	TCF dependent signaling in response to WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Transcriptional regulation of white adipocyte differentiation PCP/CE pathway PCP/CE pathway Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases
GWAS		Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Coronary artery calcification ( 23870195) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Heel bone mineral density ( 30598549) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tandem gait ( 26219847)	Bipolar disorder ( 31043756) Heel bone mineral density ( 28869591 30598549)
Interacting Genes		18 interacting genes: ANTXR1 ANTXR2 APOB ATP13A2 AXIN1 CKLF DKK1 DKK2 FZD5 FZD8 GSK3A GSK3B LRRK2 MDK SERPINF1 TLNRD1 WNT1 WNT3A	10 interacting genes: FZD8 FZD9 LRP5 LRP6 PORCN RYK SFRP1 SFRP2 VPS11 WNT3A
Entrez ID		4040	7471
HPRD ID		04617	01276
Ensembl ID		ENSG00000070018	ENSG00000125084
Uniprot IDs		F5H7J9 O75581	P04628
PDB IDs		3S2K 3S8V 3S8Z 3S94 3SOB 3SOQ 3SOV 4A0P 4DG6 4NM5 4NM7 5AIR 5FWW 5GJE 6H15 6H16 6L6R 7NAM 8CTG 8DVL 8DVM 8DVN 8FFE 8S7C
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Co-receptor Binding Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuron Apoptotic Process Regulation Of Cell Projection Organization Regulation Of Neuron Projection Development Regulation Of Dopaminergic Neuron Differentiation Beta-catenin Destruction Complex Wnt Signalosome Cell Surface Receptor Signaling Pathway Regulation Of Cell Differentiation Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Gene Expression Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Developmental Process Positive Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Cell Differentiation Positive Regulation Of Dermatome Development Signal Transduction Response To Retinoic Acid Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Membrane Permeability Anatomical Structure Morphogenesis Regulation Of Mitochondrion Organization Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Dopaminergic Neuron Differentiation Spemann Organizer Formation Wnt-Frizzled-LRP5/6 Complex Regulation Of Cellular Component Organization Positive Regulation Of Post-translational Protein Modification Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Cell Proliferation In Midbrain Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction T Cell Differentiation In Thymus Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Wnt Signaling Pathway Cellular Response To Oxygen-containing Compound	Wnt-protein Binding Canonical Wnt Signaling Pathway Wnt Signaling Pathway Wnt-Frizzled-LRP5/6 Complex Wnt Receptor Activity Non-canonical Wnt Signaling Pathway Frizzled Binding Dopaminergic Neuron Differentiation Regulation Of Dopaminergic Neuron Differentiation Cell Surface Receptor Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Neuron Differentiation Regulation Of Fat Cell Differentiation Wnt Signaling Pathway Involved In Somitogenesis Regulation Of Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Wnt Signaling Pathway Anterior/posterior Pattern Specification Negative Regulation Of Cell Growth Somitogenesis Development Of Primary Male Sexual Characteristics Positive Regulation Of Neural Precursor Cell Proliferation Segmentation Positive Regulation Of Cell Population Proliferation Coreceptor Activity Convergent Extension Involved In Axis Elongation Negative Regulation Of Growth Toxin Transmembrane Transporter Activity Regulation Of Establishment Of Planar Polarity Positive Regulation Of Fat Cell Differentiation Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Axon Extension Involved In Axon Guidance Development Of Primary Sexual Characteristics Regulation Of Mesodermal Cell Differentiation Regionalization Regulation Of Animal Organ Morphogenesis Cellular Response To X-ray Tube Morphogenesis Regulation Of Neural Precursor Cell Proliferation Cellular Developmental Process Negative Regulation Of Cell Differentiation Wnt Signalosome Regulation Of Wnt Signaling Pathway Convergent Extension Morphogenesis Of An Epithelium Tissue Development Signal Transduction Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Locomotion Anatomical Structure Formation Involved In Morphogenesis
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