LRP6 and TLNRD1

Number of citations of the paper that reports this interaction (PubMedID 16989816)
0

Data Source:
HPRD (in vivo)

		LRP6	TLNRD1
Description		LDL receptor related protein 6	talin rod domain containing 1
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GO Annotations	Cellular Component	Extracellular Region Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Caveola Cell Surface Membrane Cytoplasmic Vesicle Early Endosome Membrane Neuronal Cell Body Membrane Raft Synapse Wnt-Frizzled-LRP5/6 Complex Wnt Signalosome	Stress Fiber
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Signaling Receptor Binding Frizzled Binding Protein Binding Coreceptor Activity Wnt-protein Binding Kinase Inhibitor Activity Toxin Transmembrane Transporter Activity Protein Serine/threonine Kinase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Wnt Receptor Activity	Actin Binding Protein Binding Identical Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Endocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Nervous System Development Tissue Development Neural Crest Formation Neural Crest Cell Differentiation Wnt Signaling Pathway Vesicle-mediated Transport Midbrain Development Negative Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Apoptotic Process Chordate Embryonic Development Response To Peptide Hormone Positive Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Transmembrane Transport Canonical Wnt Signaling Pathway Cellular Response To Cholesterol Dopaminergic Neuron Differentiation Protein Localization To Plasma Membrane Cell-cell Adhesion Midbrain Dopaminergic Neuron Differentiation
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination Signaling by RNF43 mutants
Drugs
Diseases
GWAS		Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Coronary artery calcification ( 23870195) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Heel bone mineral density ( 30598549) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tandem gait ( 26219847)	Coronary artery disease ( 33020668) Myocardial infarction ( 33532862)
Interacting Genes		18 interacting genes: ANTXR1 ANTXR2 APOB ATP13A2 AXIN1 CKLF DKK1 DKK2 FZD5 FZD8 GSK3A GSK3B LRRK2 MDK SERPINF1 TLNRD1 WNT1 WNT3A	4 interacting genes: CCM2 LRP6 PICK1 SH2B2
Entrez ID		4040	59274
HPRD ID		04617	11300
Ensembl ID		ENSG00000070018	ENSG00000140406
Uniprot IDs		F5H7J9 O75581	Q9H1K6
PDB IDs		3S2K 3S8V 3S8Z 3S94 3SOB 3SOQ 3SOV 4A0P 4DG6 4NM5 4NM7 5AIR 5FWW 5GJE 6H15 6H16 6L6R 7NAM 8CTG 8DVL 8DVM 8DVN 8FFE 8S7C	6XZ3 6XZ4
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Co-receptor Binding Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuron Apoptotic Process Regulation Of Cell Projection Organization Regulation Of Neuron Projection Development Regulation Of Dopaminergic Neuron Differentiation Beta-catenin Destruction Complex Wnt Signalosome Cell Surface Receptor Signaling Pathway Regulation Of Cell Differentiation Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Gene Expression Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Developmental Process Positive Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Cell Differentiation Positive Regulation Of Dermatome Development Signal Transduction Response To Retinoic Acid Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Membrane Permeability Anatomical Structure Morphogenesis Regulation Of Mitochondrion Organization Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Dopaminergic Neuron Differentiation Spemann Organizer Formation Wnt-Frizzled-LRP5/6 Complex Regulation Of Cellular Component Organization Positive Regulation Of Post-translational Protein Modification Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Cell Proliferation In Midbrain Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction T Cell Differentiation In Thymus Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Wnt Signaling Pathway Cellular Response To Oxygen-containing Compound	Wnt Signalosome Wnt-Frizzled-LRP5/6 Complex Midbrain Dopaminergic Neuron Differentiation Embryo Development Ending In Birth Or Egg Hatching Wnt Receptor Activity Signaling Receptor Binding Multicellular Organism Development Toxin Transmembrane Transporter Activity Kinase Inhibitor Activity Cellular Developmental Process Low-density Lipoprotein Particle Receptor Activity Neural Crest Formation Neural Crest Cell Differentiation Chordate Embryonic Development Cellular Response To Cholesterol Protein Localization To Membrane Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Membrane Curvature Sensor Activity Negative Regulation Of Actin Nucleation Neuronal Ion Channel Clustering Arp2/3 Complex Binding Dendritic Spine Maintenance Long-term Synaptic Depression Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity B-1 B Cell Homeostasis Venous Blood Vessel Morphogenesis Endothelial Tube Morphogenesis Pericardium Development Blood Vessel Endothelial Cell Differentiation Endothelium Development Negative Regulation Of Smooth Muscle Cell Apoptotic Process Cellular Response To Sterol Response To Cholesterol Cell Surface Receptor Signaling Pathway Localization Within Membrane Protein Serine/threonine Kinase Inhibitor Activity Wnt-protein Binding Positive Regulation Of Receptor Internalization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Monoamine Transport Brown Fat Cell Differentiation B Cell Homeostasis Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Endothelial Cell Differentiation
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