BLOC1S3 and DTNBP1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		BLOC1S3	DTNBP1
Description		biogenesis of lysosomal organelles complex 1 subunit 3	dystrobrevin binding protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Transport Vesicle BLOC-1 Complex Axon Cytoplasm	Nucleus Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Sarcoplasm Axon Growth Cone Midbody Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane BLOC-1 Complex Cytoplasmic Vesicle Asymmetric Synapse Melanosome Membrane Sarcolemma Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Axon Cytoplasm
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity	Protein Binding
	Biological Process	Eye Development Blood Coagulation Anterograde Axonal Transport Response To Xenobiotic Stimulus Platelet Activation Neuron Projection Development Melanosome Transport Melanosome Organization Positive Regulation Of Natural Killer Cell Activation Secretion Of Lysosomal Enzymes Endosome To Melanosome Transport Pigmentation Developmental Pigmentation Anterograde Synaptic Vesicle Transport Platelet Dense Granule Organization Protein Transmembrane Transport	Kidney Development Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Receptor Internalization Blood Coagulation Memory Anterograde Axonal Transport Regulation Of Signal Transduction Positive Regulation Of Gene Expression Regulation Of Dopamine Secretion Actin Cytoskeleton Organization Neuron Projection Development Melanosome Organization Anterograde Synaptic Vesicle Transport Neuron Projection Morphogenesis Dendrite Morphogenesis Retina Development In Camera-type Eye Platelet Dense Granule Organization Regulation Of Dopamine Receptor Signaling Pathway Cilium Assembly Negative Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Protein Transmembrane Transport Regulation Of Synaptic Vesicle Exocytosis
Pathways		Golgi Associated Vesicle Biogenesis	Golgi Associated Vesicle Biogenesis
Drugs
Diseases		Hermansky-Pudlak syndrome (HPS)	Hermansky-Pudlak syndrome (HPS)
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Quantitative traits ( 19197348)	Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Corneal astigmatism ( 30306274) Femur bone mineral density x serum urate levels interaction ( 34046847) Liver enzyme levels (alkaline phosphatase) ( 33972514) Multiple myeloma ( 27363682) Serum alkaline phosphatase levels ( 33547301) Squamous cell carcinoma ( 31174203)
Interacting Genes		3 interacting genes: BLOC1S1 BLOC1S2 DTNBP1	59 interacting genes: ABI3 AKAP6 ARFIP2 BICRAL BLOC1S3 BLOC1S5 BLOC1S6 BRF1 CAP2 CCDC146 CCNA2 CCND3 CMYA5 CSGALNACT1 DCTN1 DEK DGCR6L DRC12 DST DTNA DTNB ELOVL7 HAUS1 HDGFL1 IFT20 IPO5 KALRN KANSL1 KIAA0408 KIFC3 KRT75 MACF1 NBEA NDN NECAB2 NUF2 NUP153 OIP5 P4HA3 PSME3 RAB11A RBSN RNF144B SDCBP SFR1 SHFL SNAPIN SRGAP3 SSC5D SYNE1 TNKS TPMT TRAF3IP1 TRIM2 TRIM27 TRIM9 VRK2 WASHC3 ZNF490
Entrez ID		388552	84062
HPRD ID		12527	06190
Ensembl ID		ENSG00000189114	ENSG00000047579
Uniprot IDs		Q6QNY0	A0A087WYP9 A0A0S2Z5U8 A6NFV8 D6RJC6 Q96EV8
PDB IDs
Enriched GO Terms of Interacting Partners?		Anterograde Synaptic Vesicle Transport BLOC-1 Complex Platelet Dense Granule Organization Synaptic Vesicle Transport Melanosome Organization Pigment Granule Organization Vesicle Transport Along Microtubule Anterograde Axonal Transport Vesicle Cytoskeletal Trafficking Axon Cytoplasm Axonal Transport Secretory Granule Organization Axo-dendritic Transport Organelle Transport Along Microtubule Establishment Of Vesicle Localization Vesicle Localization Regulation Of Lysosome Size BORC Complex Transport Along Microtubule Regulation Of Endosome Size Cytoskeleton-dependent Intracellular Transport Cytoplasmic Side Of Lysosomal Membrane Microtubule-based Transport Regulation Of Vesicle Size Establishment Of Organelle Localization Vesicle Organization Microtubule-based Movement Organelle Localization Neuron Projection Development Lysosome Localization Microtubule-based Process Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Intracellular Transport Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Regulation Of Cellular Component Size Cellular Localization Endosomal Transport Negative Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Glutamate Secretion, Neurotransmission Establishment Of Localization In Cell Regulation Of Glutamate Secretion, Neurotransmission Lysosomal Membrane Negative Regulation Of Dendritic Spine Development Mitochondrial Outer Membrane Permeabilization Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Glutamate Secretion Gamma-tubulin Complex Peptidyl-lysine Acetylation Asymmetric Synapse	Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Pigment Granule Localization Axonal Transport Microtubule-based Movement Transport Along Microtubule BLOC-1 Complex Anterograde Synaptic Vesicle Transport Axo-dendritic Transport Cytoskeleton-dependent Intracellular Transport Microtubule-based Process Microtubule-based Transport Establishment Of Vesicle Localization Axon Cytoplasm Microvesicle Vesicle Localization Endosome To Melanosome Transport Plasma Membrane Bounded Cell Projection Organization Synaptic Vesicle Transport Intracellular Transport Melanosome Organization Cellular Localization Nuclear Envelope Pigment Granule Organization Cell Projection Organization Anterograde Axonal Transport Organelle Organization Vesicle Transport Along Microtubule Cytoskeleton Organization Cytoplasm Microtubule Binding Nuclear Membrane Vesicle Cytoskeletal Trafficking Centrosome Establishment Of Protein Localization Cytoskeleton Secretion Of Lysosomal Enzymes Protein Transmembrane Transport Regulation Of Organelle Organization Establishment Of Localization In Cell Positive Regulation Of Pigment Cell Differentiation Spindle Pole Plasma Membrane Bounded Cell Projection Assembly Neuron Projection Development Organelle Transport Along Microtubule Regulation Of Actin Nucleation Cell Projection Assembly Protein Transport
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