BLOC1S3

Description		biogenesis of lysosomal organelles complex 1 subunit 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Transport Vesicle BLOC-1 Complex Axon Cytoplasm
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity
	Biological Process	Eye Development Blood Coagulation Anterograde Axonal Transport Response To Xenobiotic Stimulus Platelet Activation Neuron Projection Development Melanosome Transport Melanosome Organization Positive Regulation Of Natural Killer Cell Activation Secretion Of Lysosomal Enzymes Endosome To Melanosome Transport Pigmentation Developmental Pigmentation Anterograde Synaptic Vesicle Transport Platelet Dense Granule Organization Protein Transmembrane Transport
Pathways		Golgi Associated Vesicle Biogenesis
Drugs
Diseases		Hermansky-Pudlak syndrome (HPS)
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Quantitative traits ( 19197348)
Novel Interacting Genes		3 novel interacting genes: BLOC1S1 BLOC1S2 DTNBP1
Interacting Genes		3 interacting genes: BLOC1S1 BLOC1S2 DTNBP1
Entrez ID		388552
HPRD ID		12527
Ensembl ID		ENSG00000189114
Uniprot IDs		Q6QNY0
PDB IDs
Enriched GO Terms of Interacting Partners?		Anterograde Synaptic Vesicle Transport BLOC-1 Complex Platelet Dense Granule Organization Synaptic Vesicle Transport Melanosome Organization Pigment Granule Organization Vesicle Transport Along Microtubule Anterograde Axonal Transport Vesicle Cytoskeletal Trafficking Axon Cytoplasm Axonal Transport Secretory Granule Organization Axo-dendritic Transport Organelle Transport Along Microtubule Establishment Of Vesicle Localization Vesicle Localization Regulation Of Lysosome Size BORC Complex Transport Along Microtubule Regulation Of Endosome Size Cytoskeleton-dependent Intracellular Transport Cytoplasmic Side Of Lysosomal Membrane Microtubule-based Transport Regulation Of Vesicle Size Establishment Of Organelle Localization Vesicle Organization Microtubule-based Movement Organelle Localization Neuron Projection Development Lysosome Localization Microtubule-based Process Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Intracellular Transport Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Regulation Of Cellular Component Size Cellular Localization Endosomal Transport Negative Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Glutamate Secretion, Neurotransmission Establishment Of Localization In Cell Regulation Of Glutamate Secretion, Neurotransmission Lysosomal Membrane Negative Regulation Of Dendritic Spine Development Mitochondrial Outer Membrane Permeabilization Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Glutamate Secretion Gamma-tubulin Complex Peptidyl-lysine Acetylation Asymmetric Synapse
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