KLKB1 and MST1

Number of citations of the paper that reports this interaction (PubMedID 10068459)
0

Data Source:
HPRD (in vitro)

		KLKB1	MST1
Description		kallikrein B1	macrophage stimulating 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Exosome	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Endopeptidase Activity Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Factor XII Activation Proteolysis Inflammatory Response Blood Coagulation Hemostasis Zymogen Activation Plasminogen Activation Fibrinolysis Positive Regulation Of Fibrinolysis	Proteolysis Negative Regulation Of Gluconeogenesis Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Macromolecule Metabolic Process Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Intrinsic Pathway of Fibrin Clot Formation Activation of Matrix Metalloproteinases Defective factor XII causes hereditary angioedema Defective SERPING1 causes hereditary angioedema	Signaling by MST1
Drugs		Zinc Ecallantide Human C1-esterase inhibitor Conestat alfa Gabexate Zinc acetate Zinc chloride Zinc sulfate, unspecified form Lanadelumab Berotralstat
Diseases		Fletcher factor deficiency; Prekallikrein deficiency
GWAS		Apolipoprotein A-IV levels ( 27412012) B-type natriuretic peptide levels ( 25561047) Cardiac troponin-I levels ( 31014085) Circulating chromogranin peptide levels ( 28011710) Circulating vasoactive peptide levels ( 23381795) Glycine levels ( 30837465) L-arginine levels ( 27656708) Metabolic traits ( 21886157) Metabolite levels ( 22916037 22286219) Obesity-related traits ( 23251661) Plasma renin activity levels ( 25477429) Response to statin therapy ( 20339536) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 24625756 23093944 33031748) Venous thromboembolism ( 30659681)	Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 17554300 28067908 17554261 18587394 21102463) Extremely high intelligence ( 29520040) Feeling miserable ( 29500382) Inflammatory bowel disease ( 23128233 28067908) Primary sclerosing cholangitis ( 27992413 21151127 23603763) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 20228799 28067908 25082827 19915572 21297633)
Interacting Genes		8 interacting genes: F12 HGF HGFAC IGFBP3 KNG1 MST1 SERPINA5 TFPI2	10 interacting genes: BECN1 FOXO1 KLKB1 MOB1A MST1R RASSF1 SERPINA3 TNNC1 TNNI3 TNNT2
Entrez ID		3818	4485
HPRD ID		01971	00798
Ensembl ID		ENSG00000164344	ENSG00000173531
Uniprot IDs		A8K9A9 B4DMX2 E9PBC5 P03952	G3XAK1 P26927 Q53GN8
PDB IDs		2ANW 2ANY 4OGX 4OGY 5F8T 5F8X 5F8Z 5TJX 6I44 6O1G 6O1S 6T7P 7N7X 7QOX 8A3Q 8FGX	2ASU 4QT8
Enriched GO Terms of Interacting Partners?		Extracellular Space Extracellular Region Coagulation Blood Coagulation Hemostasis Extracellular Matrix Regulation Of Body Fluid Levels Peptidase Inhibitor Activity Serine-type Endopeptidase Activity Rough Endoplasmic Reticulum Zymogen Activation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Platelet Alpha Granule Lumen Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Serine-type Endopeptidase Inhibitor Activity Endopeptidase Activity Plasma Kallikrein-kinin Cascade Factor XII Activation Regulation Of Glucose Metabolic Process Seminal Clot Liquefaction Proteolysis Insulin-like Growth Factor Binding Protein Complex Platelet Dense Tubular Network Serine-type Peptidase Activity Regulation Of Wound Healing Positive Regulation Of Fibrinolysis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor Ternary Complex Acrosin Binding Heparin Binding Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of Response To Wounding Epithelial Cell Proliferation Protein Processing Regulation Of Protein Metabolic Process	Cardiac Troponin Complex Troponin Complex Muscle Filament Sliding Actin-myosin Filament Sliding Regulation Of Muscle System Process Troponin C Binding Actin-mediated Cell Contraction Troponin I Binding Troponin T Binding Cardiac Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Sarcomere Cardiac Muscle Tissue Morphogenesis Actin Filament-based Movement Cardiac Myofibril Regulation Of System Process Muscle Tissue Morphogenesis Striated Muscle Contraction Negative Regulation Of ATP-dependent Activity Contractile Muscle Fiber Regulation Of Muscle Contraction Regulation Of ATP-dependent Activity Skeletal Muscle Contraction Muscle Contraction Muscle System Process Regulation Of Muscle Filament Sliding Speed Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Cellular Response To Aluminum Ion Regulation Of Cardiac Muscle Hypertrophy Response To Metal Ion Positive Regulation Of Protein Metabolic Process Calcium-dependent Protein Binding Factor XII Activation Macrophage Colony-stimulating Factor Receptor Activity Tissue Morphogenesis Actin Filament-based Process Diaphragm Contraction Regulation Of Muscle Filament Sliding Response To Aluminum Ion Positive Regulation Of Fibrinolysis Macrophage Colony-stimulating Factor Signaling Pathway Involuntary Skeletal Muscle Contraction Phosphatidylinositol 3-kinase Complex, Class III, Type II Negative Regulation Of Lysosome Organization Cellular Response To Oxygen-glucose Deprivation Phosphatidylinositol 3-kinase Complex, Class III, Type I Regulation Of Multicellular Organismal Process Cellular Response To Hyperoxia Cytoplasmic Side Of Mitochondrial Outer Membrane Response To Mitochondrial Depolarisation
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