KLKB1

Description		kallikrein B1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Factor XII Activation Proteolysis Inflammatory Response Blood Coagulation Hemostasis Zymogen Activation Plasminogen Activation Fibrinolysis Positive Regulation Of Fibrinolysis
Pathways		Intrinsic Pathway of Fibrin Clot Formation Activation of Matrix Metalloproteinases Defective factor XII causes hereditary angioedema Defective SERPING1 causes hereditary angioedema
Drugs		Zinc Ecallantide Human C1-esterase inhibitor Conestat alfa Gabexate Zinc acetate Zinc chloride Zinc sulfate, unspecified form Lanadelumab Berotralstat
Diseases		Fletcher factor deficiency; Prekallikrein deficiency
GWAS		Apolipoprotein A-IV levels ( 27412012) B-type natriuretic peptide levels ( 25561047) Cardiac troponin-I levels ( 31014085) Circulating chromogranin peptide levels ( 28011710) Circulating vasoactive peptide levels ( 23381795) Glycine levels ( 30837465) L-arginine levels ( 27656708) Metabolic traits ( 21886157) Metabolite levels ( 22916037 22286219) Obesity-related traits ( 23251661) Plasma renin activity levels ( 25477429) Response to statin therapy ( 20339536) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 24625756 23093944 33031748) Venous thromboembolism ( 30659681)
Novel Interacting Genes		8 novel interacting genes: F12 HGF HGFAC IGFBP3 KNG1 MST1 SERPINA5 TFPI2
Interacting Genes		8 interacting genes: F12 HGF HGFAC IGFBP3 KNG1 MST1 SERPINA5 TFPI2
Entrez ID		3818
HPRD ID		01971
Ensembl ID		ENSG00000164344
Uniprot IDs		A8K9A9 B4DMX2 E9PBC5 P03952
PDB IDs		2ANW 2ANY 4OGX 4OGY 5F8T 5F8X 5F8Z 5TJX 6I44 6O1G 6O1S 6T7P 7N7X 7QOX 8A3Q 8FGX
Enriched GO Terms of Interacting Partners?		Extracellular Space Extracellular Region Coagulation Blood Coagulation Hemostasis Extracellular Matrix Regulation Of Body Fluid Levels Peptidase Inhibitor Activity Serine-type Endopeptidase Activity Rough Endoplasmic Reticulum Zymogen Activation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Platelet Alpha Granule Lumen Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Serine-type Endopeptidase Inhibitor Activity Endopeptidase Activity Plasma Kallikrein-kinin Cascade Factor XII Activation Regulation Of Glucose Metabolic Process Seminal Clot Liquefaction Proteolysis Insulin-like Growth Factor Binding Protein Complex Platelet Dense Tubular Network Serine-type Peptidase Activity Regulation Of Wound Healing Positive Regulation Of Fibrinolysis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor Ternary Complex Acrosin Binding Heparin Binding Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of Response To Wounding Epithelial Cell Proliferation Protein Processing Regulation Of Protein Metabolic Process
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