KEL and XK

Number of citations of the paper that reports this interaction (PubMedID 10556484)
0

Data Source:
HPRD (in vivo)

		KEL	XK
Description		Kell metallo-endopeptidase (Kell blood group)	X-linked Kx blood group antigen, Kell and VPS13A binding protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Proteolysis Intracellular Calcium Ion Homeostasis Regulation Of Cell Size Intracellular Magnesium Ion Homeostasis Protein Processing Regulation Of Axon Diameter Vasoconstriction Myelination Skeletal Muscle Fiber Development Establishment Of Localization In Cell Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport	Amino Acid Transport Intracellular Calcium Ion Homeostasis Regulation Of Cell Size Intracellular Magnesium Ion Homeostasis Regulation Of Axon Diameter Myelination Skeletal Muscle Fiber Development
Pathways		Peptide ligand-binding receptors	Peptide ligand-binding receptors
Drugs		Phosphoramidon
Diseases			Core neuroacanthocytosis syndromes, including: Chorea-acanthocytosis (ChAc); McLeod syndrome (MLS); Huntington's disease-like 2 (HDL2); Pantothenate kinase associated neurodegeneration (PKAN) McLeod syndrome
GWAS		Alcoholic chronic pancreatitis ( 28754779) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494)
Interacting Genes		14 interacting genes: ADIPOQ AGPS C3orf52 C5 CLDN19 EDN1 EDN2 EDN3 EMC1 EWSR1 PM20D2 TUBA1A UBC XK	4 interacting genes: CLGN CSNK2A1 KEL PRKCA
Entrez ID		3792	7504
HPRD ID		00194	02444
Ensembl ID		ENSG00000197993	ENSG00000047597
Uniprot IDs		A0A077QP03 P23276	P51811
PDB IDs
Enriched GO Terms of Interacting Partners?		Endothelin B Receptor Binding Vein Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Endothelin Artery Smooth Muscle Contraction Tonic Smooth Muscle Contraction Vascular Associated Smooth Muscle Contraction Positive Regulation Of Heart Rate Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Hormone Activity Positive Regulation Of Smooth Muscle Contraction Vasoconstriction Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Heart Contraction Leukocyte Chemotaxis Regulation Of Systemic Arterial Blood Pressure Axon Extension Regulation Of Blood Pressure Positive Regulation Of Muscle Contraction Intracellular Magnesium Ion Homeostasis Neutrophil Chemotaxis Smooth Muscle Contraction Intracellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Cell Chemotaxis Regulation Of Chemotaxis Regulation Of Vasoconstriction Neutrophil Migration Positive Regulation Of Prostaglandin Biosynthetic Process Calcium Ion Homeostasis Regulation Of Leukocyte Migration Leukocyte Migration Granulocyte Chemotaxis Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Neuron Projection Extension Endothelin Receptor Signaling Pathway Regulation Of Prostaglandin Biosynthetic Process Magnesium Ion Homeostasis Granulocyte Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Fatty Acid Metabolic Process Regulation Of Cell Migration Regulation Of Heart Rate Regulation Of Cell Motility Regulation Of Locomotion Chemotaxis Developmental Cell Growth Response To Tumor Necrosis Factor Regulation Of Ketone Metabolic Process Myeloid Leukocyte Migration Locomotion	Protein Folding Macromolecule Catabolic Process Protein Catabolic Process Protein Metabolic Process Negative Regulation Of Translation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Protein Kinase C Signaling Positive Regulation Of Aggrephagy Regulation Of Axon Diameter Regulation Of Angiotensin-activated Signaling Pathway Proteolysis Intracellular Magnesium Ion Homeostasis Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Desmosome Assembly Aggrephagy Double-strand Break Repair Via Classical Nonhomologous End Joining Protein Serine Kinase Activity Protein Targeting To Vacuole Involved In Autophagy Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Protein Serine/threonine Kinase Activity Regulation Of Translation Magnesium Ion Homeostasis Regulation Of Cell Projection Size Mitotic Nuclear Membrane Disassembly Diacylglycerol Binding Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Desmosome Organization Positive Regulation Of Bone Resorption Positive Regulation Of Macrophage Differentiation Membrane Disassembly Nuclear Membrane Disassembly Response To Phorbol 13-acetate 12-myristate Negative Regulation Of Glial Cell Apoptotic Process Response To Corticosterone MRNA Methylguanosine-cap Decapping Diacylglycerol-dependent Serine/threonine Kinase Activity
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