KCNE2

Description		potassium voltage-gated channel subfamily E regulatory subunit 2
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GO Annotations	Cellular Component	Lysosome Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Apical Plasma Membrane Monoatomic Ion Channel Complex
	Molecular Function	Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Transmembrane Transporter Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Delayed Rectifier Potassium Channel Activity Potassium Ion Import Across Plasma Membrane
Pathways		Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs		Enflurane Promethazine Miconazole
Diseases		Atrial fibrillation Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Body mass index (smoking years interaction) ( 23192594) Cancer ( 29299148) Chronic obstructive pulmonary disease ( 30804561) Coronary artery disease ( 28714974 33020668 32469254 26343387 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Heel bone mineral density ( 28869591 30598549) Height ( 31562340 20881960) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1/FVC) ( 28166213 30804560) Myocardial infarction ( 26343387 26708285) Myocardial infarction (early onset) ( 19198609) Pulmonary function ( 21946350)
Novel Interacting Genes		4 novel interacting genes: HCN2 HCN4 KCNH2 KCNQ1
Interacting Genes		4 interacting genes: HCN2 HCN4 KCNH2 KCNQ1
Entrez ID		9992
HPRD ID		04813
Ensembl ID		ENSG00000159197
Uniprot IDs		Q9Y6J6
PDB IDs		2M0Q
Enriched GO Terms of Interacting Partners?		Potassium Ion Import Across Plasma Membrane Voltage-gated Potassium Channel Activity Potassium Channel Activity Inorganic Cation Import Across Plasma Membrane Monoatomic Ion Channel Complex Import Across Plasma Membrane Potassium Ion Transmembrane Transport Membrane Depolarization During Action Potential Monoatomic Ion Channel Activity Potassium Ion Transport Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Cardiac Conduction Membrane Depolarization HCN Channel Complex Cellular Response To CAMP Voltage-gated Potassium Channel Complex Regulation Of Membrane Potential Response To CAMP Cellular Response To CGMP Regulation Of Heart Rate Action Potential Intracellularly CAMP-activated Cation Channel Activity Metal Ion Transport Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Response To CGMP Response To Purine-containing Compound Inorganic Ion Transmembrane Transport Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane Sodium Ion Transport Membrane Depolarization During Cardiac Muscle Cell Action Potential Voltage-gated Sodium Channel Activity Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Contraction Muscle Contraction CAMP Binding Monoatomic Ion Transport Membrane Repolarization During Cardiac Muscle Cell Action Potential Delayed Rectifier Potassium Channel Activity Membrane Repolarization During Action Potential Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Sodium Ion Import Across Plasma Membrane
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