KCNA2 and PTPRA

Number of citations of the paper that reports this interaction (PubMedID 9878055)
43

Data Source:
HPRD (in vivo, in vitro)

		KCNA2	PTPRA
Description		potassium voltage-gated channel subfamily A member 2	protein tyrosine phosphatase receptor type A
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Lamellipodium Axon Dendrite Lamellipodium Membrane Neuronal Cell Body Membrane Paranodal Junction Monoatomic Ion Channel Complex Potassium Channel Complex Presynaptic Membrane Cell Projection Neuron Projection Axon Initial Segment Perikaryon Axon Terminus Juxtaparanode Region Of Axon Calyx Of Held Synapse Postsynaptic Membrane Anchoring Junction Glutamatergic Synapse	Plasma Membrane Focal Adhesion Membrane Receptor Complex Extracellular Exosome Anchoring Junction
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Kinesin Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Regulation Of Dopamine Secretion Neuronal Action Potential Sensory Perception Of Pain Optic Nerve Development Optic Nerve Structural Organization Cerebral Cortex Development Corpus Callosum Development Monoatomic Ion Transmembrane Transport Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Protein Homooligomerization Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Potassium Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane Regulation Of Presynaptic Membrane Potential	Signal Transduction Integrin-mediated Signaling Pathway Regulation Of Focal Adhesion Assembly
Pathways		Voltage gated Potassium channels	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth RAF/MAP kinase cascade
Drugs		Enflurane Promethazine Miconazole Dalfampridine
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 28552196) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		16 interacting genes: CNTNAP2 CTTN DLG1 DLG4 ETV1 FAM3C KCNA1 KCNA3 KCNA4 KCNA5 KCNAB1 KCNAB2 NEU1 PTK2B PTPRA RHOA	21 interacting genes: BCAR1 CALM1 FYN GABARAPL2 GAS1 GRB2 HSPB1 HUNK KCNA2 LCOR LINC00839 MBP POFUT1 PRKCD PTGER4 PTPRD PTPRF PTPRM PTPRS RET SRC
Entrez ID		3737	5786
HPRD ID		01443	01476
Ensembl ID		ENSG00000177301	ENSG00000132670
Uniprot IDs		P16389	A0A1S5UZ22 B7Z2A4 P18433
PDB IDs			6UZT
Enriched GO Terms of Interacting Partners?		Voltage-gated Potassium Channel Complex Juxtaparanode Region Of Axon Voltage-gated Potassium Channel Activity Cell Junction Potassium Ion Transmembrane Transport Delayed Rectifier Potassium Channel Activity Potassium Ion Transport Regulation Of Membrane Potential Regulation Of System Process Potassium Channel Activity Anchoring Junction Membrane Repolarization During Action Potential Regulation Of Potassium Ion Transport Axon Membrane Repolarization Dendrite Cytoplasmic Side Of Plasma Membrane Ionotropic Glutamate Receptor Binding Action Potential Monoatomic Ion Channel Complex Cell Projection Plasma Membrane Transmembrane Transporter Binding Glutamatergic Synapse Dendritic Spine Potassium Channel Regulator Activity Metal Ion Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Actin Filament Polymerization Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Monoatomic Ion Channel Activity Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Supramolecular Fiber Organization Regulation Of Muscle Contraction Positive Regulation Of Cytoskeleton Organization Inorganic Ion Transmembrane Transport Protein Homooligomerization Positive Regulation Of Protein-containing Complex Assembly Synaptic Membrane Regulation Of Potassium Ion Transmembrane Transport Paranode Region Of Axon Potassium Channel Complex Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Alcohol Dehydrogenase (NADP+) Activity Positive Regulation Of Protein Polymerization Regulation Of Muscle System Process Protein-containing Complex Assembly Regulation Of Cellular Component Size	Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Transmembrane Receptor Protein Tyrosine Phosphatase Activity Plasma Membrane Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Synaptic Membrane Adhesion Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Ephrin Receptor Binding Cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Protein Tyrosine Phosphatase Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Defense Response Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity T Cell Costimulation Cell-cell Adhesion Phosphoprotein Phosphatase Activity Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Response To Growth Factor Fc Receptor Signaling Pathway Regulation Of Anatomical Structure Morphogenesis Immune Response-activating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Cellular Response To Hydrogen Peroxide Phospholipase Activator Activity Regulation Of Apoptotic Signaling Pathway Immune Effector Process Regulation Of Immune Response Cell-cell Junction Regulation Of Cell Migration ERBB Signaling Pathway Insulin Receptor Substrate Binding Immune Response-regulating Signaling Pathway Activation Of Immune Response Membrane Regulation Of Cell Motility Regulation Of Neuron Projection Development Protein Tyrosine Kinase Activator Activity
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