KCNA2 and KCNA3

Number of citations of the paper that reports this interaction (PubMedID 12944270)
67

Data Source:
HPRD (in vitro)

		KCNA2	KCNA3
Description		potassium voltage-gated channel subfamily A member 2	potassium voltage-gated channel subfamily A member 3
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Lamellipodium Axon Dendrite Lamellipodium Membrane Neuronal Cell Body Membrane Paranodal Junction Monoatomic Ion Channel Complex Potassium Channel Complex Presynaptic Membrane Cell Projection Neuron Projection Axon Initial Segment Perikaryon Axon Terminus Juxtaparanode Region Of Axon Calyx Of Held Synapse Postsynaptic Membrane Anchoring Junction Glutamatergic Synapse	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Axon Monoatomic Ion Channel Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Kinesin Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Monoatomic Ion Channel Activity Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding
	Biological Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Regulation Of Dopamine Secretion Neuronal Action Potential Sensory Perception Of Pain Optic Nerve Development Optic Nerve Structural Organization Cerebral Cortex Development Corpus Callosum Development Monoatomic Ion Transmembrane Transport Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Protein Homooligomerization Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Potassium Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane Regulation Of Presynaptic Membrane Potential	Action Potential Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Protein Homooligomerization Transmembrane Transport Potassium Ion Transmembrane Transport
Pathways		Voltage gated Potassium channels	Voltage gated Potassium channels
Drugs		Enflurane Promethazine Miconazole Dalfampridine	Enflurane Clofazimine Promethazine Miconazole Dalfampridine
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Acute lymphoblastic leukemia (childhood) ( 22076464)
Interacting Genes		16 interacting genes: CNTNAP2 CTTN DLG1 DLG4 ETV1 FAM3C KCNA1 KCNA3 KCNA4 KCNA5 KCNAB1 KCNAB2 NEU1 PTK2B PTPRA RHOA	11 interacting genes: BAX CAV1 CD3D CSNK2B DEFB4A DLG1 DLG4 DOLK IL16 KCNA1 KCNA2
Entrez ID		3737	3738
HPRD ID		01443	15937
Ensembl ID		ENSG00000177301	ENSG00000177272
Uniprot IDs		P16389	P22001
PDB IDs			4BGC 7EJ1 7EJ2 7SSV 7SSX 7SSY 7SSZ 8DFL
Enriched GO Terms of Interacting Partners?		Voltage-gated Potassium Channel Complex Juxtaparanode Region Of Axon Voltage-gated Potassium Channel Activity Cell Junction Potassium Ion Transmembrane Transport Delayed Rectifier Potassium Channel Activity Potassium Ion Transport Regulation Of Membrane Potential Regulation Of System Process Potassium Channel Activity Anchoring Junction Membrane Repolarization During Action Potential Regulation Of Potassium Ion Transport Axon Membrane Repolarization Dendrite Cytoplasmic Side Of Plasma Membrane Ionotropic Glutamate Receptor Binding Action Potential Monoatomic Ion Channel Complex Cell Projection Plasma Membrane Transmembrane Transporter Binding Glutamatergic Synapse Dendritic Spine Potassium Channel Regulator Activity Metal Ion Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Actin Filament Polymerization Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Monoatomic Ion Channel Activity Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Supramolecular Fiber Organization Regulation Of Muscle Contraction Positive Regulation Of Cytoskeleton Organization Inorganic Ion Transmembrane Transport Protein Homooligomerization Positive Regulation Of Protein-containing Complex Assembly Synaptic Membrane Regulation Of Potassium Ion Transmembrane Transport Paranode Region Of Axon Potassium Channel Complex Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Alcohol Dehydrogenase (NADP+) Activity Positive Regulation Of Protein Polymerization Regulation Of Muscle System Process Protein-containing Complex Assembly Regulation Of Cellular Component Size	Juxtaparanode Region Of Axon Regulation Of Membrane Potential Endoplasmic Reticulum Voltage-gated Potassium Channel Complex Regulation Of Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Monoatomic Ion Transport Epithelial Cell Proliferation Cellular Response To Topologically Incorrect Protein Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Metal Ion Transport Signal Transduction Regulation Of Transport Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Monoatomic Ion Transport Membrane Raft Organization Regulation Of Cardiac Muscle Cell Contraction Regulation Of Muscle Contraction Regulation Of Cardiac Muscle Cell Action Potential Protein Localization To Postsynaptic Membrane Membrane Repolarization During Action Potential Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Protein Localization To Postsynapse Ionotropic Glutamate Receptor Binding Membrane Repolarization Neuronal Action Potential Axon Initial Segment Delayed Rectifier Potassium Channel Activity Localization Within Membrane Endothelial Cell Proliferation Cell Junction Positive Regulation Of Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Membrane Regulation Of System Process Protein-macromolecule Adaptor Activity Regulation Of Calcium Ion Transport Protein Localization To Cell Periphery Metal Ion Transport Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Muscle System Process Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Immune System Process T Cell Homeostatic Proliferation Positive Regulation Of Calcium Ion Transmembrane Transport BAX Complex Cell Surface Receptor Signaling Pathway Release Of Matrix Enzymes From Mitochondria
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