ITIH2 and SPINT2

Number of citations of the paper that reports this interaction (PubMedID 8601712)
0

Data Source:
BioGRID (pull down)

		ITIH2	SPINT2
Description		inter-alpha-trypsin inhibitor heavy chain 2	serine peptidase inhibitor, Kunitz type 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Cytoplasm Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Hyaluronic Acid Binding Peptidase Inhibitor Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity
	Biological Process	Hyaluronan Metabolic Process	Neural Tube Closure Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Cell-cell Adhesion Epithelial Cell Morphogenesis Involved In Placental Branching Basement Membrane Organization Cellular Response To BMP Stimulus Negative Regulation Of Cell Motility Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	MET Receptor Activation Signaling by MST1
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Ovarian reserve ( 22116950)	Alanine aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494)
Interacting Genes		3 interacting genes: ATP5F1C FCER1A SPINT2	6 interacting genes: APP CTSB HGFAC ITIH2 ITIH3 SUMO4
Entrez ID		3698	10653
HPRD ID		00890	05495
Ensembl ID		ENSG00000151655	ENSG00000167642
Uniprot IDs		P19823	A0A140VJV6 O43291
PDB IDs			4U32
Enriched GO Terms of Interacting Partners?		High-affinity IgE Receptor Activity Type I Hypersensitivity Epithelial Cell Morphogenesis Involved In Placental Branching Eosinophil Degranulation IgE Binding Type 2 Immune Response Hypersensitivity	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Hyaluronan Metabolic Process Endopeptidase Inhibitor Activity Glycosaminoglycan Metabolic Process Extracellular Region Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Macromolecule Metabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Regulation Of Protein Localization To Nucleus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Peptidase Inhibitor Complex SUMO Ligase Complex Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Endolysosome Lumen Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Extracellular Exosome Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation
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