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ITIH2

Description inter-alpha-trypsin inhibitor heavy chain 2
Image No pdb structure
GO Annotations Cellular Component
  • Extracellular Region
  • Endoplasmic Reticulum Lumen
  • Extracellular Matrix
  • Extracellular Exosome
  • Blood Microparticle
Molecular Function
  • Endopeptidase Inhibitor Activity
  • Serine-type Endopeptidase Inhibitor Activity
  • Protein Binding
  • Hyaluronic Acid Binding
  • Peptidase Inhibitor Activity
Biological Process
  • Hyaluronan Metabolic Process
Pathways
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • Post-translational protein phosphorylation
Drugs
  • Zinc
  • Copper
  • Zinc acetate
  • Zinc chloride
  • Zinc sulfate, unspecified form
Diseases
GWAS
  • Ovarian reserve ( 22116950)
Novel Interacting Genes 3 novel interacting genes: ATP5F1C FCER1A SPINT2
Interacting Genes 3 interacting genes: ATP5F1C FCER1A SPINT2
Entrez ID 3698
HPRD ID 00890
Ensembl ID ENSG00000151655
Uniprot IDs P19823
PDB IDs
Enriched GO Terms of Interacting Partners?
  • High-affinity IgE Receptor Activity
  • Type I Hypersensitivity
  • Epithelial Cell Morphogenesis Involved In Placental Branching
  • Eosinophil Degranulation
  • IgE Binding
  • Type 2 Immune Response
  • Hypersensitivity
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