ITGAE and CDH1

Number of citations of the paper that reports this interaction (PubMedID 12434297)
46

Data Source:
HPRD (in vivo)

		ITGAE	CDH1
Description		integrin subunit alpha E	cadherin 1
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GO Annotations	Cellular Component	Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane	Extracellular Region Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Adherens Junction Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Membrane Lateral Plasma Membrane Catenin Complex Flotillin Complex Lamellipodium Cell Junction Desmosome Cortical Actin Cytoskeleton Apical Junction Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Postsynapse Glutamatergic Synapse
	Molecular Function	Signaling Receptor Activity Metal Ion Binding	Calcium Ion Binding Protein Binding Beta-catenin Binding Ankyrin Binding GTPase Activating Protein Binding Identical Protein Binding Gamma-catenin Binding Cadherin Binding Metal Ion Binding Cell Adhesion Molecule Binding Cell-cell Adhesion Mediator Activity Protein Tyrosine Kinase Binding
	Biological Process	Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Adhesion	Cell Morphogenesis Desmosome Assembly Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Synapse Assembly Response To Xenobiotic Stimulus Response To Toxic Substance Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Negative Regulation Of Axon Extension Neuron Projection Development Cell Junction Assembly Adherens Junction Organization Positive Regulation Of Protein Import Into Nucleus Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of DNA-templated Transcription Regulation Of Transport Cellular Response To Lithium Ion Response To Heparin Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Cell-cell Adhesion Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Response To Gram-positive Bacterium Positive Regulation Of Protein Localization
Pathways		Integrin cell surface interactions	Degradation of the extracellular matrix Degradation of the extracellular matrix Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Apoptotic cleavage of cell adhesion proteins Adherens junctions interactions RHO GTPases activate IQGAPs InlA-mediated entry of Listeria monocytogenes into host cells Regulation of CDH1 Function Regulation of CDH1 mRNA translation by microRNAs Degradation of CDH1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Formation of definitive endoderm Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells
Drugs
Diseases			Penile cancer Breast cancer Gastric cancer Nasopharyngeal cancer Hepatocellular carcinoma Thyroid cancer
GWAS		Attention deficit hyperactivity disorder ( 18839057)	Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Colorectal cancer ( 19011631) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous malignant melanoma ( 26237428 32341527) Glycated hemoglobin levels ( 34059833) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Late-onset Alzheimer's disease ( 27770636) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Nevus count or cutaneous melanoma ( 32341527) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) Ulcerative colitis ( 19915572)
Interacting Genes		6 interacting genes: CDH1 CHFR EED ITGB7 MYH10 TRIM54	76 interacting genes: ACTR3 AKT1 ANAPC7 AOPEP ARHGAP32 ARVCF AURKB CA9 CASP3 CASP8 CBLL1 CCNB1 CDC42 CDH5 CDK8 CHEK1 CSE1L CSNK2A1 CTNNA1 CTNNB1 CTNND1 CTNND2 DNMT3A EGFR ERBIN EZR FADD FARP2 FER FGFR1 FYN GALNT12 GNA12 GNA13 GSK3B HDAC1 HDAC2 HEMGN HRAS HSD17B3 IQGAP1 IRS1 ITGAE ITGB7 JUP KEAP1 MAD2L2 MAP2K1 MAPK3 MKI67 MSANTD3 MYO6 NANS NDRG1 NEDD9 NFE2L2 PIP5K1C PKD1 PKP4 PPP1CA PSEN1 PTPN14 PTPRF PTPRM PTTG1 RAB8B RRM2 SFRP2 STOML2 STX17 TMOD1 UCA1 UCHL3 VCL YES1 ZNF510
Entrez ID		3682	999
HPRD ID		05249	01885
Ensembl ID		ENSG00000083457	ENSG00000039068
Uniprot IDs		P38570	A0A0U2ZQU7 B3GN61 P12830 Q9UII7
PDB IDs		8ZJF	1O6S 2O72 2OMT 2OMU 2OMV 2OMX 2OMY 2OMZ 3FF7 3FF8 3L6X 3L6Y 4ZT1 4ZTE 6CXY 6OLE 6OLF 6OLG 6VEL 7STZ 8H62
Enriched GO Terms of Interacting Partners?		Cytoplasmic Side Of Plasma Membrane Cell Adhesion Molecule Binding Symbiont Entry Into Host Cell Cell-matrix Adhesion Involved In Ameboidal Cell Migration Virus Receptor Activity Integrin Alpha4-beta7 Complex Fourth Ventricle Development Regulation Of Adaxial/abaxial Pattern Formation Meiotic Spindle Checkpoint Signaling Myosin II Filament Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Response To Heparin Cellular Response To Indole-3-methanol Cell Adhesion Cell Migration Response To Indole-3-methanol Response To Gram-positive Bacterium Lamellipodium Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Desmosome Assembly Immune Response In Gut-associated Lymphoid Tissue Biological Process Involved In Interaction With Host Third Ventricle Development Pronucleus Sex Chromatin Negative Regulation Of Meiotic Cell Cycle Phase Transition Meiotic Cell Cycle Checkpoint Signaling Flotillin Complex Positive Regulation Of Protein Transport Actomyosin Substrate-dependent Cell Migration, Cell Extension Postsynaptic Actin Cytoskeleton Ventricular Cardiac Muscle Cell Development Supramolecular Fiber GTPase Activating Protein Binding Cerebellar Purkinje Cell Layer Development Chromatin Silencing Complex Cell Motility Gamma-catenin Binding Desmosome Organization Cellular Response To Lithium Ion Positive Regulation Of Establishment Of Protein Localization Protein Localization To Membrane Adult Heart Development Cardiac Myofibril Assembly Lateral Ventricle Development ESC/E(Z) Complex Facultative Heterochromatin Formation	Cell-cell Adhesion Adherens Junction Cell Adhesion Regulation Of Cell Motility Regulation Of Cell Migration Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Cytoplasm Focal Adhesion Cadherin Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Junction Regulation Of Signal Transduction Intracellular Signal Transduction Signal Transduction Anchoring Junction Regulation Of Signaling Regulation Of Cell Communication Plasma Membrane Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Projection Organization Regulation Of Mitotic Cell Cycle Response To Xenobiotic Stimulus Cell Cortex Negative Regulation Of Apoptotic Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Protein Catabolic Process Regulation Of Cell Adhesion Regulation Of Protein Metabolic Process Positive Regulation Of Cell Migration Cell Motility Regulation Of Cell Population Proliferation Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Cycle Nucleus Positive Regulation Of Cell Motility Negative Regulation Of Cell Motility Cytosol Cytoskeleton Positive Regulation Of Locomotion ERBB Signaling Pathway Cell Migration Positive Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Component Organization
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