ITGA7 and CHRNA1

Number of citations of the paper that reports this interaction (PubMedID 10910772)
0

Data Source:
HPRD (in vivo)

		ITGA7	CHRNA1
Description		integrin subunit alpha 7	cholinergic receptor nicotinic alpha 1 subunit
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integrin Complex Cell Surface Membrane	Plasma Membrane Acetylcholine-gated Channel Complex Cell Surface Membrane Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane Presynapse Postsynaptic Specialization Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity Metal Ion Binding	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Binding Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Muscle Organ Development Regulation Of Cell Shape Heterotypic Cell-cell Adhesion Endodermal Cell Differentiation Leukocyte Migration Cell-cell Adhesion	Skeletal Muscle Contraction Monoatomic Ion Transport Monoatomic Cation Transport Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Neuromuscular Junction Development Neuronal Action Potential Monoatomic Ion Transmembrane Transport Response To Nicotine Regulation Of Membrane Potential Muscle Cell Cellular Homeostasis Skeletal Muscle Tissue Growth Musculoskeletal Movement Neuromuscular Process Membrane Depolarization Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Neuron Cellular Homeostasis Acetylcholine Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		Integrin cell surface interactions Laminin interactions Laminin interactions ECM proteoglycans	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs			Lamotrigine Cisatracurium Agmatine
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy	Congenital myasthenic syndrome Multiple pterygium syndrome, including: Multiple pterygium syndrome, lethal type (LMPS); Multiple pterygium syndrome, Escobar variant (EVMPS)
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278)	Atrial fibrillation ( 29892015)
Interacting Genes		5 interacting genes: CHRNA1 FHL2 FHL3 HTRA2 MYOC	5 interacting genes: CHRND CHRNE CHRNG ITGA7 LILRB3
Entrez ID		3679	1134
HPRD ID		02761	00007
Ensembl ID		ENSG00000135424	ENSG00000138435
Uniprot IDs		J3KNV4 Q13683	P02708 Q53SH4
PDB IDs			4ZJS 5HBT
Enriched GO Terms of Interacting Partners?		Osteoblast Differentiation Atrial Cardiac Muscle Cell Development Z Disc Mitochondrial Intermembrane Space Skeletal Muscle Hypertrophy Pentacyclic Triterpenoid Metabolic Process Negative Regulation Of Type 2 Mitophagy Negative Regulation Of Intracellular Signal Transduction Muscle Cell Cellular Homeostasis Acetylcholine Binding Muscle System Process Acetylcholine Receptor Activity Regulation Of Cell Communication Skeletal Muscle Tissue Growth Synaptic Transmission, Cholinergic Musculoskeletal Movement Regulation Of Membrane Potential Acetylcholine-gated Monoatomic Cation-selective Channel Activity Regulation Of Signaling Acetylcholine-gated Channel Complex Negative Regulation Of Signal Transduction Negative Regulation Of Calcineurin-NFAT Signaling Cascade Heart Trabecula Formation Focal Adhesion Ventricular Cardiac Muscle Cell Development Negative Regulation Of Calcium-mediated Signaling Transcription Factor Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Membrane Depolarization Node Of Ranvier ERBB2-ERBB3 Signaling Pathway Negative Regulation Of Rho Protein Signal Transduction ERBB3 Signaling Pathway Neuronal Ion Channel Clustering ERBB2 Signaling Pathway Myosin Light Chain Binding Regulation Of Mitochondrial Depolarization Positive Regulation Of Mitochondrial Depolarization Clustering Of Voltage-gated Sodium Channels Skeletal Muscle Adaptation Myelination In Peripheral Nervous System Positive Regulation Of Execution Phase Of Apoptosis Response To Herbicide Mitochondrial Protein Catabolic Process Ubiquitin Ligase Inhibitor Activity CD40 Receptor Complex Serine-type Endopeptidase Complex Negative Regulation Of Mitophagy Execution Phase Of Apoptosis	Acetylcholine-gated Monoatomic Cation-selective Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Channel Complex Synaptic Transmission, Cholinergic Extracellular Ligand-gated Monoatomic Ion Channel Activity Skeletal Muscle Contraction Acetylcholine Receptor Signaling Pathway Transmembrane Signaling Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Postsynaptic Signal Transduction Membrane Depolarization Excitatory Postsynaptic Potential Striated Muscle Contraction Regulation Of Postsynaptic Membrane Potential Monoatomic Ion Channel Activity Muscle Contraction Postsynaptic Membrane Muscle System Process Chemical Synaptic Transmission Trans-synaptic Signaling Neuron Projection Synaptic Signaling Regulation Of Membrane Potential Neuromuscular Junction Cell-cell Signaling Signaling Cell Communication Monoatomic Ion Transmembrane Transport Signal Transduction Plasma Membrane Monoatomic Ion Transport Synapse Skeletal Muscle Tissue Growth Inhibitory MHC Class I Receptor Activity Regulation Of Biological Quality Signaling Receptor Activity Transmembrane Transport Acetylcholine Binding Musculoskeletal Movement Monoatomic Cation Transmembrane Transporter Activity System Process Integrin Complex Postsynaptic Specialization Membrane Ligand-gated Monoatomic Ion Channel Activity Negative Regulation Of Osteoclast Differentiation Membrane Heterotypic Cell-cell Adhesion Endodermal Cell Differentiation Channel Activity Negative Regulation Of Myeloid Leukocyte Differentiation
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