ITGA7

Description		integrin subunit alpha 7
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integrin Complex Cell Surface Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity Metal Ion Binding
	Biological Process	Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Muscle Organ Development Regulation Of Cell Shape Heterotypic Cell-cell Adhesion Endodermal Cell Differentiation Leukocyte Migration Cell-cell Adhesion
Pathways		Integrin cell surface interactions Laminin interactions Laminin interactions ECM proteoglycans
Drugs
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278)
Novel Interacting Genes		5 novel interacting genes: CHRNA1 FHL2 FHL3 HTRA2 MYOC
Interacting Genes		5 interacting genes: CHRNA1 FHL2 FHL3 HTRA2 MYOC
Entrez ID		3679
HPRD ID		02761
Ensembl ID		ENSG00000135424
Uniprot IDs		J3KNV4 Q13683
PDB IDs
Enriched GO Terms of Interacting Partners?		Osteoblast Differentiation Atrial Cardiac Muscle Cell Development Z Disc Mitochondrial Intermembrane Space Skeletal Muscle Hypertrophy Pentacyclic Triterpenoid Metabolic Process Negative Regulation Of Type 2 Mitophagy Negative Regulation Of Intracellular Signal Transduction Muscle Cell Cellular Homeostasis Acetylcholine Binding Muscle System Process Acetylcholine Receptor Activity Regulation Of Cell Communication Skeletal Muscle Tissue Growth Synaptic Transmission, Cholinergic Musculoskeletal Movement Regulation Of Membrane Potential Acetylcholine-gated Monoatomic Cation-selective Channel Activity Regulation Of Signaling Acetylcholine-gated Channel Complex Negative Regulation Of Signal Transduction Negative Regulation Of Calcineurin-NFAT Signaling Cascade Heart Trabecula Formation Focal Adhesion Ventricular Cardiac Muscle Cell Development Negative Regulation Of Calcium-mediated Signaling Transcription Factor Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Membrane Depolarization Node Of Ranvier ERBB2-ERBB3 Signaling Pathway Negative Regulation Of Rho Protein Signal Transduction ERBB3 Signaling Pathway Neuronal Ion Channel Clustering ERBB2 Signaling Pathway Myosin Light Chain Binding Regulation Of Mitochondrial Depolarization Positive Regulation Of Mitochondrial Depolarization Clustering Of Voltage-gated Sodium Channels Skeletal Muscle Adaptation Myelination In Peripheral Nervous System Positive Regulation Of Execution Phase Of Apoptosis Response To Herbicide Mitochondrial Protein Catabolic Process Ubiquitin Ligase Inhibitor Activity CD40 Receptor Complex Serine-type Endopeptidase Complex Negative Regulation Of Mitophagy Execution Phase Of Apoptosis
Tagcloud ?