IRF4 and HPSE

		IRF4	HPSE
Description		interferon regulatory factor 4	heparanase
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GO Annotations	Cellular Component	Chromatin Nucleosome Nucleus Nucleoplasm Cytoplasm Cytosol Membrane	Extracellular Region Extracellular Space Nucleus Nucleoplasm Lysosome Lysosomal Membrane Membrane Extracellular Matrix Specific Granule Lumen Lysosomal Lumen Membrane Raft Heparanase Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Beta-glucuronidase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Heparanase Activity Syndecan Binding
	Biological Process	Immune System Process Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Negative Regulation Of Toll-like Receptor Signaling Pathway T Cell Activation Defense Response To Protozoan Myeloid Dendritic Cell Differentiation Regulation Of T-helper Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Multicellular Organismal Process T-helper 17 Cell Lineage Commitment Positive Regulation Of Cold-induced Thermogenesis	Proteoglycan Metabolic Process Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Blood Coagulation Heparan Sulfate Proteoglycan Catabolic Process Heparin Proteoglycan Metabolic Process Positive Regulation Of Osteoblast Proliferation Wound Healing Response To Antibiotic Regulation Of Hair Follicle Development Positive Regulation Of Hair Follicle Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Involved In Wound Healing Establishment Of Endothelial Barrier Vascular Wound Healing Protein Transmembrane Transport
Pathways		Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Interferon alpha/beta signaling Nuclear events stimulated by ALK signaling in cancer Regulation of MITF-M-dependent genes involved in pigmentation	HS-GAG degradation Neutrophil degranulation
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alopecia areata ( 25608926) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid disease ( 32581359) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Basal cell carcinoma ( 31174203 27539887) Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Blond vs non-blond hair color ( 26184321) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Celiac disease ( 22057235 20190752) Chronic lymphocytic leukemia ( 28165464 26956414 23770605 24292274 18758461) Crohn's disease ( 26192919) Cutaneous squamous cell carcinoma ( 27424798 32041948) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Epstein-Barr virus EA-D antibody levels ( 33204752) Eye color ( 20585627 30664655) Eye color (brightness) ( 30664655) Eye color traits ( 30166351) Facial pigmentation ( 25705849) Feeling nervous ( 29500382) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 30664655 20585627 29662168 23548203 26926045) Hair greying ( 26926045) Hair morphology traits ( 30166351) Hematology traits ( 23303382) IgA nephropathy ( 32912934) Inflammatory bowel disease ( 26192919) Keratinocyte cancer (MTAG) ( 31174203) Light vs. dark hair color ( 26184321) Limited cutaneous systemic scleroderma ( 29293537) Low tan response ( 29739929) Lung adenocarcinoma ( 28604730) Lung cancer in ever smokers ( 28604730) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 27182965 29146897 28196072) Medication use (thyroid preparations) ( 31015401) Melanoma ( 28212542) Membranous nephropathy ( 32231244) Monobrow ( 27182965) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Nevus count ( 30429480) Non-melanoma skin cancer ( 29739929 23548203) Progressive supranuclear palsy ( 21685912) Psoriasis ( 25903422 23143594 25574825) Rheumatoid arthritis ( 30423114 24390342) Rosacea symptom severity ( 29771307) Skin aging (microtopography measurement) ( 28502801) Skin colour saturation ( 25963972) Skin pigmentation ( 30664655) Skin pigmentation traits ( 30166351) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Squamous cell carcinoma ( 26829030 31174203) Sunburns ( 23548203) Systemic lupus erythematosus ( 33536424) Tanning ( 23548203) Type 1 diabetes ( 34012112 34127860) Vitiligo ( 27723757) White blood cell count ( 32888494) Youthful appearance (self-reported) ( 32339537)	Age-related cognitive decline (executive function) (slope of z-scores) ( 30954325)
Interacting Genes		28 interacting genes: BATF BCL6 CUTA ELP1 ETV7 FKBP4 FLRT3 GIPC2 HOXB13 HOXC11 HPSE INSL4 IRAK1 MYD88 NEDD9 NFATC2 PRDM1 PROX1 SPI1 SPIB STAT6 TBCC TLK2 TOP1 TRAF2 TSEN54 USP4 YTHDC2	1 interacting genes: IRF4
Entrez ID		3662	10855
HPRD ID		03543	05286
Ensembl ID		ENSG00000137265	ENSG00000173083
Uniprot IDs		Q15306	Q9Y251
PDB IDs		2DLL 6TD4 7JM4 7O56 7OGS 7OOT 7RH2	5E8M 5E97 5E98 5E9B 5E9C 5L9Y 5L9Z 5LA4 5LA7 6ZDM 7PR7 7PR8 7PRT 7RG8 7YI7 7YJC 8B0B 8B0C 8BAC 8CQI 8E07 8E08 8JYG 8OHQ 8OHR
Enriched GO Terms of Interacting Partners?		Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Positive Regulation Of Multicellular Organismal Process Regulation Of Lymphocyte Activation Nucleoplasm Leukocyte Activation Involved In Immune Response B Cell Activation Involved In Immune Response DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Activation Involved In Immune Response Regulation Of Cell Activation DNA-binding Transcription Factor Activity Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Isotype Switching To IgE Isotypes Isotype Switching Positive Regulation Of B Cell Activation Somatic Diversification Of Immunoglobulins Involved In Immune Response Positive Regulation Of Gene Expression B Cell Activation Regulation Of Macromolecule Metabolic Process Somatic Recombination Of Immunoglobulin Gene Segments Leukocyte Activation Chromatin Lipopolysaccharide-mediated Signaling Pathway DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Lymphocyte Activation Involved In Immune Response DNA Binding Regulation Of Gene Expression Somatic Diversification Of Immunoglobulins Negative Regulation Of RNA Metabolic Process Somatic Cell DNA Recombination Nucleus Toll Signaling Pathway Macrophage Differentiation Regulation Of B Cell Activation Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Process Cell Activation Positive Regulation Of Macromolecule Biosynthetic Process Interleukin-33-mediated Signaling Pathway Lymphocyte Activation Regulation Of Metabolic Process Regulation Of Primary Metabolic Process T-helper 2 Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Immune System Process Myeloid Leukocyte Differentiation Regulation Of Immune Response Negative Regulation Of Transcription By RNA Polymerase II	T-helper Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Myeloid Dendritic Cell Activation Positive Regulation Of Interleukin-4 Production Regulation Of Interleukin-4 Production Dendritic Cell Differentiation Alpha-beta T Cell Lineage Commitment Positive Regulation Of Interleukin-13 Production Response To Protozoan Negative Regulation Of Toll-like Receptor Signaling Pathway CD4-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Toll-like Receptor Signaling Pathway T Cell Lineage Commitment Myeloid Dendritic Cell Differentiation Defense Response To Protozoan Positive Regulation Of Interleukin-2 Production T-helper 17 Cell Lineage Commitment Positive Regulation Of Interleukin-10 Production Regulation Of T-helper Cell Differentiation Regulation Of Interleukin-2 Production Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Interleukin-10 Production Regulation Of CD4-positive, Alpha-beta T Cell Activation Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Cold-induced Thermogenesis Nucleosome Regulation Of Alpha-beta T Cell Activation Myeloid Leukocyte Activation Regulation Of Cold-induced Thermogenesis Myeloid Leukocyte Differentiation Cell Fate Commitment Regulation Of T Cell Differentiation
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