HPSE

Description		heparanase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Lysosome Lysosomal Membrane Membrane Extracellular Matrix Specific Granule Lumen Lysosomal Lumen Membrane Raft Heparanase Complex
	Molecular Function	Beta-glucuronidase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Heparanase Activity Syndecan Binding
	Biological Process	Proteoglycan Metabolic Process Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Blood Coagulation Heparan Sulfate Proteoglycan Catabolic Process Heparin Proteoglycan Metabolic Process Positive Regulation Of Osteoblast Proliferation Wound Healing Response To Antibiotic Regulation Of Hair Follicle Development Positive Regulation Of Hair Follicle Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Involved In Wound Healing Establishment Of Endothelial Barrier Vascular Wound Healing Protein Transmembrane Transport
Pathways		HS-GAG degradation Neutrophil degranulation
Drugs
Diseases
GWAS		Age-related cognitive decline (executive function) (slope of z-scores) ( 30954325)
Novel Interacting Genes		1 novel interacting genes: IRF4
Interacting Genes		1 interacting genes: IRF4
Entrez ID		10855
HPRD ID		05286
Ensembl ID		ENSG00000173083
Uniprot IDs		Q9Y251
PDB IDs		5E8M 5E97 5E98 5E9B 5E9C 5L9Y 5L9Z 5LA4 5LA7 6ZDM 7PR7 7PR8 7PRT 7RG8 7YI7 7YJC 8B0B 8B0C 8BAC 8CQI 8E07 8E08 8JYG 8OHQ 8OHR
Enriched GO Terms of Interacting Partners?		T-helper Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Myeloid Dendritic Cell Activation Positive Regulation Of Interleukin-4 Production Regulation Of Interleukin-4 Production Dendritic Cell Differentiation Alpha-beta T Cell Lineage Commitment Positive Regulation Of Interleukin-13 Production Response To Protozoan Negative Regulation Of Toll-like Receptor Signaling Pathway CD4-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Toll-like Receptor Signaling Pathway T Cell Lineage Commitment Myeloid Dendritic Cell Differentiation Defense Response To Protozoan Positive Regulation Of Interleukin-2 Production T-helper 17 Cell Lineage Commitment Positive Regulation Of Interleukin-10 Production Regulation Of T-helper Cell Differentiation Regulation Of Interleukin-2 Production Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Interleukin-10 Production Regulation Of CD4-positive, Alpha-beta T Cell Activation Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Cold-induced Thermogenesis Nucleosome Regulation Of Alpha-beta T Cell Activation Myeloid Leukocyte Activation Regulation Of Cold-induced Thermogenesis Myeloid Leukocyte Differentiation Cell Fate Commitment Regulation Of T Cell Differentiation
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