RXFP2 and INSL3

Number of citations of the paper that reports this interaction (PubMedID 12114498)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		RXFP2	INSL3
Description		relaxin family peptide receptor 2	insulin like 3
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Extracellular Space
	Molecular Function	G Protein-coupled Receptor Activity G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Peptide Hormone Binding	Protease Binding Signaling Receptor Binding Insulin Receptor Binding Hormone Activity Protein Binding
	Biological Process	Oocyte Maturation Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Male Gonad Development Hormone-mediated Signaling Pathway Negative Regulation Of Apoptotic Process	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Spermatogenesis Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Wound Healing
Pathways		G alpha (s) signalling events Relaxin receptors	G alpha (s) signalling events Relaxin receptors
Drugs
Diseases		46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism	46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism
GWAS		Essential hypertension (time to event) ( 32589924) Glycated hemoglobin levels in type 1 diabetes ( 30674623) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 30578418) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		2 interacting genes: INSL3 RLN2	3 interacting genes: C12orf57 RBPJ RXFP2
Entrez ID		122042	3640
HPRD ID		05976	08854
Ensembl ID		ENSG00000133105	ENSG00000248099
Uniprot IDs		Q8WXD0	P51460
PDB IDs		2M96	2H8B 2K6T 2K6U
Enriched GO Terms of Interacting Partners?		Hormone Activity	MAML1-RBP-Jkappa- ICN1 Complex Developmental Maturation Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Positive Regulation Of Ephrin Receptor Signaling Pathway Club Cell Differentiation Epidermal Cell Fate Specification Endocardium Morphogenesis Aortic Valve Development Pulmonary Valve Development Blood Vessel Endothelial Cell Fate Specification Hair Follicle Maturation Blood Vessel Lumenization Endocardium Development Arterial Endothelial Cell Fate Commitment Endothelial Cell Fate Specification Auditory Receptor Cell Fate Commitment Semi-lunar Valve Development Regulation Of Cell Adhesion Involved In Heart Morphogenesis Corpus Callosum Morphogenesis Psychomotor Behavior Third Ventricle Development Positive Regulation Of Transcription Of Notch Receptor Target Sebaceous Gland Development Dorsal Aorta Morphogenesis Cardiac Muscle Cell Myoblast Differentiation Endothelial Tube Morphogenesis Heart Field Specification Atrioventricular Canal Development Epithelial Cell Fate Commitment Secondary Heart Field Specification Cardiac Left Ventricle Morphogenesis Protein-hormone Receptor Activity Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of Timing Of Cell Differentiation Cardioblast Differentiation Ventricular Trabecula Myocardium Morphogenesis Regulation Of Development, Heterochronic Specification Of Animal Organ Identity Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Skeletal Muscle Contraction Labyrinthine Layer Blood Vessel Development Heart Trabecula Morphogenesis Myeloid Dendritic Cell Differentiation Myeloid Dendritic Cell Activation Lung Epithelial Cell Differentiation Heart Valve Development Aorta Morphogenesis Negative Regulation Of Stem Cell Proliferation Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Cardiac Muscle Cell Proliferation
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