INHBA and CD86

		INHBA	CD86
Description		inhibin subunit beta A	CD86 molecule
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Activin A Complex Inhibin A Complex Perinuclear Region Of Cytoplasm Enzyme Activator Complex	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Centriolar Satellite Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Peptide Hormone Binding Identical Protein Binding Protein-containing Complex Binding Type II Activin Receptor Binding	Virus Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity Receptor Ligand Activity
	Biological Process	Ovarian Follicle Development Mesoderm Formation Hair Follicle Development Hematopoietic Progenitor Cell Differentiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Lipid Metabolic Process Steroid Biosynthetic Process Autophagy Defense Response Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-cell Signaling Nervous System Development Steroid Metabolic Process Androgen Metabolic Process Negative Regulation Of Cell Population Proliferation Male Gonad Development Response To Wounding Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Striatal Medium Spiny Neuron Differentiation Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Type II Interferon Production Activin Receptor Signaling Pathway Positive Regulation Of Collagen Biosynthetic Process Endodermal Cell Differentiation Negative Regulation Of Phosphorylation Odontogenesis Hemoglobin Biosynthetic Process Progesterone Secretion Negative Regulation Of B Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Mesodermal Cell Differentiation Cell Development Animal Organ Development System Development Positive Regulation Of Protein Metabolic Process Sertoli Cell Differentiation Roof Of Mouth Development Positive Regulation Of Ovulation Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Cardiac Fibroblast Cell Development Eyelid Development In Camera-type Eye Testosterone Biosynthetic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Cholesterol Cellular Response To Hypoxia Cellular Response To Oxygen-glucose Deprivation GABAergic Neuron Differentiation Extrinsic Apoptotic Signaling Pathway Androst-4-ene-3,17-dione Biosynthetic Process Response To Aldosterone Cellular Response To Angiotensin Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Adaptive Immune Response Immune System Process Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation T Cell Costimulation Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of T Cell Proliferation T Cell Activation B Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of DNA-templated Transcription Lymphocyte Activation Symbiont Entry Into Host Cell Cellular Response To Lipopolysaccharide Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Signaling by Activin Signaling by Activin Signaling by BMP Glycoprotein hormones Antagonism of Activin by Follistatin TGFBR3 regulates activin signaling	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway Co-inhibition by CTLA4 Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		Garetosmab	Antithymocyte immunoglobulin (rabbit) Abatacept Belatacept Bryostatin 1
Diseases
GWAS		Asthma ( 29273806) Cortisol levels (saliva) ( 28843169) Menarche (age at onset) ( 21102462 25231870 27182965) Parent of origin effect on language impairment (paternal) ( 24571439) Pit-and-Fissure caries ( 23470693)	Autoimmune thyroid disease ( 32581359) Diffuse large B cell lymphoma ( 25261932) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Follicular lymphoma ( 25279986) Gut microbiota (functional units) ( 27694959) Multiple sclerosis ( 21833088 22190364 24076602 27386562 31604244) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 19838195) Type 2 diabetes ( 30718926)
Interacting Genes		17 interacting genes: ACVR1 ACVR1B ACVR2A ACVR2B BMPR2 CD86 CFTR CHRDL2 ENG FST FSTL3 IGFBP7 INHA INHBB INHBC RALA TGFBR3	15 interacting genes: CD28 CD80 CSTA CTLA4 ECE2 FXR1 INHBA KPNA1 MARCHF8 MCM2 P4HA2 PARP1 TEX55 TRA2A TRH
Entrez ID		3624	942
HPRD ID		00929	03011
Ensembl ID		ENSG00000122641	ENSG00000114013
Uniprot IDs		A4D1W7 P08476	A0A0X9R4E0 A8K632 P42081
PDB IDs		1NYS 1NYU 1S4Y 2ARP 2ARV 2B0U 2P6A 3B4V 4MID 5HLY 5HLZ 6Y6N 6Y6O 7OLY 7U5P 9I5W	1I85 1NCN 5YXK 8FXX 8FXY 8HXB 8HXC
Enriched GO Terms of Interacting Partners?		Activin Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Activin Receptor Signaling Pathway Activin Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Growth Factor Binding Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Complex Regulation Of Cell Communication Regulation Of Signaling Regulation Of Multicellular Organismal Development Positive Regulation Of SMAD Protein Signal Transduction Inhibin-betaglycan-ActRII Complex Activin Receptor Activity, Type II Positive Regulation Of Biomineral Tissue Development Inhibin Binding Activin Receptor Activity BMP Binding Positive Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Response To Growth Factor Regulation Of Developmental Process Positive Regulation Of Activin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Receptor Complex Activin Receptor Activity, Type I BMP Receptor Activity Positive Regulation Of Multicellular Organismal Process Cell Surface Positive Regulation Of Bone Mineralization Regulation Of Ossification Regulation Of Multicellular Organismal Process Animal Organ Development Positive Regulation Of Ossification Extracellular Space Coreceptor Activity Regulation Of Cell Differentiation Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Odontogenesis Of Dentin-containing Tooth	Protein Complex Involved In Cell Adhesion Regulation Of Lymphocyte Differentiation Regulation Of DNA Metabolic Process NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Response To Aldosterone NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of DNA Recombination NAD+-protein-histidine ADP-ribosyltransferase Activity Response To Mineralocorticoid Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Circadian Sleep/wake Cycle NAD+-protein-tyrosine ADP-ribosyltransferase Activity Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation T Cell Costimulation Regulation Of T Cell Proliferation Regulation Of B Cell Activation Regulation Of Cell Development Regulation Of Regulatory T Cell Differentiation Regulation Of Lymphocyte Activation Regulation Of Hemopoiesis Positive Regulation Of Interleukin-2 Production Regulation Of T Cell Differentiation Negative Regulation Of Cell Activation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Leukocyte Activation Negative Regulation Of B Cell Activation Activin A Complex Androst-4-ene-3,17-dione Biosynthetic Process Thyrotropin-releasing Hormone Activity Negative Regulation Of Immune System Process Coreceptor Activity Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Lymphocyte Differentiation Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Myofibroblast Differentiation Regulation Of Cell Differentiation NAD+-protein-serine ADP-ribosyltransferase Activity Regulation Of Interleukin-2 Production Regulation Of Leukocyte Proliferation Cardiac Fibroblast Cell Development Type II Activin Receptor Binding Inhibin A Complex Positive Regulation Of Ovulation Progesterone Secretion Positive Regulation Of DNA Recombination Regulation Of Behavior Transcription By RNA Polymerase II Positive Regulation Of Alpha-beta T Cell Activation
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