INHBA and ACVR2B

Number of citations of the paper that reports this interaction (PubMedID 22267736)
61

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)
HPRD (in vivo)

		INHBA	ACVR2B
Description		inhibin subunit beta A	activin A receptor type 2B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Activin A Complex Inhibin A Complex Perinuclear Region Of Cytoplasm Enzyme Activator Complex	Cytoplasm Plasma Membrane Membrane Protein-containing Complex Receptor Complex Activin Receptor Complex
	Molecular Function	Signaling Receptor Binding Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Peptide Hormone Binding Identical Protein Binding Protein-containing Complex Binding Type II Activin Receptor Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type II Transferase Activity Activin Receptor Activity Kinase Activator Activity Growth Factor Binding Metal Ion Binding Activin Binding
	Biological Process	Ovarian Follicle Development Mesoderm Formation Hair Follicle Development Hematopoietic Progenitor Cell Differentiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Lipid Metabolic Process Steroid Biosynthetic Process Autophagy Defense Response Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-cell Signaling Nervous System Development Steroid Metabolic Process Androgen Metabolic Process Negative Regulation Of Cell Population Proliferation Male Gonad Development Response To Wounding Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Striatal Medium Spiny Neuron Differentiation Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Type II Interferon Production Activin Receptor Signaling Pathway Positive Regulation Of Collagen Biosynthetic Process Endodermal Cell Differentiation Negative Regulation Of Phosphorylation Odontogenesis Hemoglobin Biosynthetic Process Progesterone Secretion Negative Regulation Of B Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Mesodermal Cell Differentiation Cell Development Animal Organ Development System Development Positive Regulation Of Protein Metabolic Process Sertoli Cell Differentiation Roof Of Mouth Development Positive Regulation Of Ovulation Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Cardiac Fibroblast Cell Development Eyelid Development In Camera-type Eye Testosterone Biosynthetic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Cholesterol Cellular Response To Hypoxia Cellular Response To Oxygen-glucose Deprivation GABAergic Neuron Differentiation Extrinsic Apoptotic Signaling Pathway Androst-4-ene-3,17-dione Biosynthetic Process Response To Aldosterone Cellular Response To Angiotensin Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of DNA-templated Transcription Intracellular Iron Ion Homeostasis Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Signal Transduction Insulin Secretion Negative Regulation Of Ossification Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Developmental Process Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Roof Of Mouth Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Trophoblast Cell Migration Cellular Response To Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Adipose Tissue Development
Pathways		Signaling by Activin Signaling by Activin Signaling by BMP Glycoprotein hormones Antagonism of Activin by Follistatin TGFBR3 regulates activin signaling	Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP
Drugs		Garetosmab
Diseases			Heterotaxy; Situs ambiguus
GWAS		Asthma ( 29273806) Cortisol levels (saliva) ( 28843169) Menarche (age at onset) ( 21102462 25231870 27182965) Parent of origin effect on language impairment (paternal) ( 24571439) Pit-and-Fissure caries ( 23470693)	Bitter beverage consumption ( 31046077) Body size at age 10 ( 32376654) Estimated glomerular filtration rate ( 31015462 31152163) P wave duration ( 24850809)
Interacting Genes		17 interacting genes: ACVR1 ACVR1B ACVR2A ACVR2B BMPR2 CD86 CFTR CHRDL2 ENG FST FSTL3 IGFBP7 INHA INHBB INHBC RALA TGFBR3	27 interacting genes: ACVR1B BMP10 BMP2 BMP7 CRIPTO DLG1 ERBIN FBXO7 GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN NHERF2 NODAL SCRIB SNTB1 SNX1 SNX2 SNX27 SNX6 SYNJ2BP TGFBRAP1 WNT5A
Entrez ID		3624	93
HPRD ID		00929	04106
Ensembl ID		ENSG00000122641	ENSG00000114739
Uniprot IDs		A4D1W7 P08476	Q13705
PDB IDs		1NYS 1NYU 1S4Y 2ARP 2ARV 2B0U 2P6A 3B4V 4MID 5HLY 5HLZ 6Y6N 6Y6O 7OLY 7U5P 9I5W	2H62 2QLU 4FAO 5NGV 5NHR 7MRZ 7OLY
Enriched GO Terms of Interacting Partners?		Activin Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Activin Receptor Signaling Pathway Activin Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Growth Factor Binding Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Complex Regulation Of Cell Communication Regulation Of Signaling Regulation Of Multicellular Organismal Development Positive Regulation Of SMAD Protein Signal Transduction Inhibin-betaglycan-ActRII Complex Activin Receptor Activity, Type II Positive Regulation Of Biomineral Tissue Development Inhibin Binding Activin Receptor Activity BMP Binding Positive Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Response To Growth Factor Regulation Of Developmental Process Positive Regulation Of Activin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Receptor Complex Activin Receptor Activity, Type I BMP Receptor Activity Positive Regulation Of Multicellular Organismal Process Cell Surface Positive Regulation Of Bone Mineralization Regulation Of Ossification Regulation Of Multicellular Organismal Process Animal Organ Development Positive Regulation Of Ossification Extracellular Space Coreceptor Activity Regulation Of Cell Differentiation Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Odontogenesis Of Dentin-containing Tooth	Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Growth Factor Activity Activin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cytokine Activity Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cartilage Development Regulation Of Signaling Regulation Of Signal Transduction BMP Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Developmental Process Anatomical Structure Morphogenesis Retromer, Tubulation Complex Regulation Of Cell Communication Retromer Complex Regulation Of Cell Population Proliferation Negative Regulation Of Cell Differentiation Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Extracellular Space Regulation Of Cartilage Development Negative Regulation Of Signaling Negative Regulation Of Cell Communication Signal Transduction Signaling Receptor Binding Regulation Of Multicellular Organismal Process Tissue Morphogenesis Regulation Of Cell Differentiation Morphogenesis Of A Branching Structure Cellular Response To Growth Factor Stimulus Regulation Of Locomotion Tube Morphogenesis Regulation Of Reproductive Process Response To Growth Factor Animal Organ Development Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Cartilage Development Morphogenesis Of An Epithelium Extracellular Region Nodal Signaling Pathway Mesoderm Formation
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