ACVR2B and IGSF1

Number of citations of the paper that reports this interaction (PubMedID 11266516)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		ACVR2B	IGSF1
Description		activin A receptor type 2B	immunoglobulin superfamily member 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Protein-containing Complex Receptor Complex Activin Receptor Complex	Extracellular Region Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type II Transferase Activity Activin Receptor Activity Kinase Activator Activity Growth Factor Binding Metal Ion Binding Activin Binding	Protein Binding Inhibin Binding Activin Receptor Antagonist Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of DNA-templated Transcription Intracellular Iron Ion Homeostasis Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Signal Transduction Insulin Secretion Negative Regulation Of Ossification Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Developmental Process Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Roof Of Mouth Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Trophoblast Cell Migration Cellular Response To Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Adipose Tissue Development	Immune Response-regulating Signaling Pathway Regulation Of DNA-templated Transcription Negative Regulation Of Activin Receptor Signaling Pathway
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP
Drugs
Diseases		Heterotaxy; Situs ambiguus
GWAS		Bitter beverage consumption ( 31046077) Body size at age 10 ( 32376654) Estimated glomerular filtration rate ( 31015462 31152163) P wave duration ( 24850809)	Age at voice drop ( 27182965) Menarche (age at onset) ( 27182965)
Interacting Genes		27 interacting genes: ACVR1B BMP10 BMP2 BMP7 CRIPTO DLG1 ERBIN FBXO7 GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN NHERF2 NODAL SCRIB SNTB1 SNX1 SNX2 SNX27 SNX6 SYNJ2BP TGFBRAP1 WNT5A	8 interacting genes: ACVR1 ACVR1B ACVR2A ACVR2B HECTD1 IGF1 INHBB RANBP10
Entrez ID		93	3547
HPRD ID		04106	02138
Ensembl ID		ENSG00000114739	ENSG00000147255
Uniprot IDs		Q13705	Q8N6C5
PDB IDs		2H62 2QLU 4FAO 5NGV 5NHR 7MRZ 7OLY
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Growth Factor Activity Activin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cytokine Activity Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cartilage Development Regulation Of Signaling Regulation Of Signal Transduction BMP Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Developmental Process Anatomical Structure Morphogenesis Retromer, Tubulation Complex Regulation Of Cell Communication Retromer Complex Regulation Of Cell Population Proliferation Negative Regulation Of Cell Differentiation Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Extracellular Space Regulation Of Cartilage Development Negative Regulation Of Signaling Negative Regulation Of Cell Communication Signal Transduction Signaling Receptor Binding Regulation Of Multicellular Organismal Process Tissue Morphogenesis Regulation Of Cell Differentiation Morphogenesis Of A Branching Structure Cellular Response To Growth Factor Stimulus Regulation Of Locomotion Tube Morphogenesis Regulation Of Reproductive Process Response To Growth Factor Animal Organ Development Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Cartilage Development Morphogenesis Of An Epithelium Extracellular Region Nodal Signaling Pathway Mesoderm Formation	Activin Receptor Signaling Pathway Activin Receptor Complex Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Activin Receptor Signaling Pathway Activin Receptor Activity Positive Regulation Of Activin Receptor Signaling Pathway Activin Receptor Activity, Type I Growth Factor Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Osteoblast Differentiation Gastrulation With Mouth Forming Second Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Ossification Regulation Of Osteoblast Differentiation Activin Receptor Activity, Type II Positive Regulation Of Bone Mineralization Negative Regulation Of Ossification Gastrulation Inhibin Binding Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Mesoderm Development Cellular Response To Growth Factor Stimulus Regulation Of Bone Mineralization BMP Receptor Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Response To Growth Factor Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Positive Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Protein Serine/threonine Kinase Activity Positive Regulation Of Multicellular Organismal Process Osteoblast Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling System Development Protein Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Reproductive Process Negative Regulation Of Multicellular Organismal Process Skeletal System Development Receptor Complex Endothelial Cell Differentiation Cellular Response To BMP Stimulus Kinase Activity
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