INCENP and AURKC

Number of citations of the paper that reports this interaction (PubMedID 36736316)
80

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		INCENP	AURKC
Description		inner centromere protein	aurora kinase C
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Synaptonemal Complex Lateral Element Central Element Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Chromocenter Microtubule Cytoskeleton Nuclear Body Midbody Chromosome Passenger Complex Protein-containing Complex Meiotic Spindle Midzone	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Spindle Pole Nucleus Chromosome Cytoplasm Centrosome Spindle Cytoskeleton Spindle Microtubule Midbody Chromosome Passenger Complex Spindle Midzone
	Molecular Function	Protein Binding Molecular Function Activator Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Mitotic Cell Cycle Mitotic Cytokinesis Chromosome Segregation Mitotic Spindle Midzone Assembly Meiotic Spindle Midzone Assembly Cell Division Metaphase Chromosome Alignment Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Spindle Assembly Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis	Protein Phosphorylation Mitotic Spindle Organization Attachment Of Spindle Microtubules To Kinetochore Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly Cell Division Meiotic Cell Cycle
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Reversine	SNS-314 Fostamatinib
Diseases
GWAS		Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Major depressive disorder x sex interaction ( 34099189) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Prostate cancer ( 29892016) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		11 interacting genes: AURKB AURKC BIRC5 CBX5 CDCA8 EVI5 FLOT1 H2AZ1 H3C14 MARK2 PIN1	13 interacting genes: BIRC5 BIRC7 BRCA1 CADPS CENPA H3C1 INCENP LNX1 NEDD4 NEDD4L OTX2 SRPK1 TACC2
Entrez ID		3619	6795
HPRD ID		05103	04605
Ensembl ID		ENSG00000149503	ENSG00000105146
Uniprot IDs		Q9NQS7	Q9UQB9
PDB IDs		2QFA 4AF3 5IEH 5IEK 6GR8 6GR9 6YIE 6YIF 6YIH 8RUP 9ESA	6GR8 6GR9 9ESA
Enriched GO Terms of Interacting Partners?		Chromosome Passenger Complex Mitotic Spindle Midzone Assembly Spindle Midzone Assembly Regulation Of Cytokinesis Spindle Midzone Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Cytokinesis Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Chromosome, Centromeric Region Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Chromosome Chromocenter Regulation Of Cell Division Positive Regulation Of Mitotic Cytokinesis Midbody Regulation Of Metaphase Plate Congression Regulation Of Mitotic Cytokinesis Microtubule Cytoskeleton Organization Positive Regulation Of Cell Cycle Checkpoint Spindle Positive Regulation Of Cell Division Mitotic Spindle Organization Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Mitotic Nuclear Division Positive Regulation Of Chromosome Segregation Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Chromosome Separation Regulation Of Nuclear Division Spindle Microtubule Spindle Organization Mitotic Spindle Assembly Kinetochore Microtubule-based Process Cell Division Regulation Of Mitotic Sister Chromatid Separation Mitotic Cytokinesis Cytoskeleton Organization Regulation Of Chromosome Separation Positive Regulation Of Cell Cycle Process Cytoskeleton-dependent Cytokinesis Regulation Of Mitotic Metaphase/anaphase Transition Spindle Assembly Regulation Of Organelle Organization Regulation Of Sister Chromatid Segregation Positive Regulation Of Cell Cycle Regulation Of Cell Cycle Process Regulation Of Chromosome Segregation	Ubiquitin-protein Transferase Activity Chromosome Segregation Microtubule Cytoskeleton Organization Involved In Mitosis Chromosome Ubiquitin Protein Ligase Activity Chromosome Passenger Complex Negative Regulation Of Potassium Ion Export Across Plasma Membrane Protein-containing Complex Organelle Localization Mitotic Cytokinesis Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Sodium Channel Inhibitor Activity Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Potassium Channel Inhibitor Activity Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Spindle Midzone Assembly Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Mitotic Cytokinesis Regulation Of Metaphase Plate Congression Mitotic Spindle Organization Cytoskeleton-dependent Cytokinesis Regulation Of Mitotic Cytokinesis Lateral Element Negative Regulation Of Sodium Ion Transport Nucleoplasm Protein Ubiquitination Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of Cell Cycle Checkpoint RNA Polymerase Binding Receptor Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Enzyme Binding Microtubule-based Process Spindle Organization Chromosome, Centromeric Region Positive Regulation Of Chromosome Segregation Pericentric Heterochromatin Negative Regulation Of Potassium Ion Transport Post-translational Protein Modification Cysteine-type Endopeptidase Inhibitor Activity Microtubule Cytoskeleton Organization Positive Regulation Of Chromosome Separation Neuromuscular Junction Development Positive Regulation Of Cytokinesis
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